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Lecture 10 Web: pollev.com/ucibio Text: To: 37607 Type in: 169964.

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Presentation on theme: "Lecture 10 Web: pollev.com/ucibio Text: To: 37607 Type in: 169964."— Presentation transcript:

1 Lecture 10 Web: pollev.com/ucibio Text: To: Type in:

2 K m, V max, V 0 – What do they all mean? Parameters for enzyme action Rates and regulation!

3 1. K m [S] at which rate is ½ of V Max NOT ________ of enzyme for substrate High K m = ?

4 Physiological relevance of K M Coordination of metabolism: Glucose  Energy Glucose  Glycogen First step in both = Glc  Glc-6-PO 4 Some tissues store, others need energy Convert Glc  Glycogen only when [Glc] high?

5 2. V Max Compare rates of reaction at given [S] Some idea of efficacy of enzyme Regulation

6 3. k Cat Also an idea of rate #molecules converted per second Time per conversion

7 Enzyme regulation Structurally, how can we regulate enzymes?

8 Enzyme regulation: Terms Allosteric Homotropic Heterotropic Reversible Irreversible

9 Competitive inhibition

10 Allosteric noncompetitive inhibitor

11 Allosteric competitive inhibitor

12 Allosteric competitive inhibitor


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