Dynamic sensitivity of tests in natural history of hepatitis C FibroMeterFibroscan Year 3 vs year 1: p<10 -3 Year 3 vs year 1: p=0.410 Calès, Clin Biochem 2010
Dynamic reproducibility of tests in natural history of hepatitis C FibroMeter Fibroscan Calès, Clin Biochem 2010 Year 3 vs 1 r ic =0.83 Year 3 vs 1 r ic =0.44
Dynamic reproducibility (2 years) of mesures of liver lesions FibrosisActivity Histological mesure Blood test Calès, J Viral Hepatitis 2012
Comparaison of liver histology, morphometry and blood tests to assess fibrosis progression 101 pts with HCV±HIV Follow-up: 96 w HistologyBlood tests* * * * : significant change Calès, J Viral Hepatitis 2012 The area of fibrosis was the sole histological characteristic with a significant change (%). CirrhoMeter was the only blood test with a significantly higher change than that of area of fibrosis (p=0.039). Area of fibrosis CirrhoMeter
P = P = r ic = r ic = a b cd From Calès, J Viral Hepatitis 2012
Agreement between biopsies From Calès, J Viral Hepatitis 2012
Conclusion Considering non-invasive tests in HCV hepatitis, blood test and elastometry have the advantage to be independent methods. In case of discrepant results, two solutions: – Another third examination like liver biopsy – Or test combination For follow-up, certain blood test(s) could be more reproducible and more sensitive to detect small changes than other examinations.