17 Dynamic sensitivity of tests in natural history of hepatitis C FibroMeterFibroscanYear 3 vs year 1: p<10-3Year 3 vs year 1: p=0.410Calès, Clin Biochem 2010
18 Dynamic reproducibility of tests in natural history of hepatitis C FibroMeterFibroscanYear 3 vs 1ric=0.83Year 3 vs 1ric=0.44Calès, Clin Biochem 2010
19 Dynamic reproducibility (2 years) of mesures of liver lesions FibrosisActivityHistological mesure Blood testCalès, J Viral Hepatitis 2012
20 Comparaison of liver histology, morphometry and blood tests to assess fibrosis progression 101 pts with HCV±HIVFollow-up: 96 wHistologyBlood tests*The area of fibrosis was the sole histological characteristic with a significant change (%).*CirrhoMeter was the only blood test with a significantly higher change than that of area of fibrosis (p=0.039).*CirrhoMeterArea of fibrosisCalès, J Viral Hepatitis 2012* : significant change20
21 a b c d P = 0.003 P = 0.020 From Calès, J Viral Hepatitis 2012 ric = 0.815ric = 0.826cd
23 ConclusionConsidering non-invasive tests in HCV hepatitis, blood test and elastometry have the advantage to be independent methods.In case of discrepant results, two solutions:Another third examination like liver biopsyOr test combinationFor follow-up, certain blood test(s) could be more reproducible and more sensitive to detect small changes than other examinations.