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Luke the Limping Labrador Linden Craig, DVM, PhD, DACVP Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only.

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Presentation on theme: "Luke the Limping Labrador Linden Craig, DVM, PhD, DACVP Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only."— Presentation transcript:

1 Luke the Limping Labrador Linden Craig, DVM, PhD, DACVP Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

2 Signalment 10 year old Intact male Black Labrador retriever Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

3 Clinical History One year duration Swelling and lameness Left stifle Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

4 Luke at UT Painful swollen stifle FNA – viscous fluid Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

5 UT Radiographs Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

6 Biopsy Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

7 Diagnosis? Synovial myxoma Benign, slow growing Nodular morphology Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

8 Synovial Myxoma 1. Adult Doberman – stifle synovectomy  curative yr old Doberman – stifle amputation  curative 3. 9 yr old English spaniel – C2 & C3 incidental finding at necropsy Tumors in Domestic Animals 4 th ed, DJ Meuten Ed, 2002, p. 213 Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

9 Synovial Myxoma 1.Labrador retriever – tarsus 2.Miniature poodle – stifle 3.Doberman cross – carpus 4.Doberman cross – stifle 5.Doberman – carpus 6.Doberman – stifle doxorubicin  died The diagnosis and prognosis of synovial tumors in dogs: 35 cases Vet Path 39:66-73, 2002 Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

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11 Luke’s Leg Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

12 Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

13 Synovial Myxoma Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

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16 Invasion into bone Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

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18 Synovium Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

19 Synoviocytes Secrete synovial fluid Dendritic cells + Type C synoviocyte Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

20 Synoviocytes H&E CD18 Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

21 Synoviocytes  tumors (Craig Hypothesis) Type A – Dendritic cell –Histiocytic sarcoma Type B – Secretes synovial fluid –Synovial myxoma Type C – Transitional or stem cell –Synovial cell sarcoma Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

22 Synovial Tumors - Survival The diagnosis and prognosis of synovial tumors in dogs: 35 cases Vet Path 39:66-73, 2002 Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

23 Synovial Myxoma Summary Slow growing Nodular Benign Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only


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