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00.111000.1110 A375A375R2 Vemurafenib (µM) BRAF (Full Length) p61-BRAF Isoform pMEK pERK Tubulin Supplementary Figure S1 0.004.01.040.01.030.10.313100.01.11 A375-R4 NRas Q61KA375 Vemurafenib (µM) pMEK pS338-cRaf pERK Ras Tubulin B A
Supplementary Figure S2 Vehicle Vemurafenib LY2835219 Vemurafenib
Supplementary Figure S3 A375A375-RV2 pERK Tubulin Vemurafenib (µM)
Supplementary Figure S4 DMSO 1.5 M M M14 M14-R %G1= 54.25 %S = 34.96 %G2/M = 10.79 %G1= 82.10 %S = 2.73 %G2/M = 15.17 %G1= 74.95 %S = 3.81 %G2/M = 21.24 %G1= 55.23 %S = 13.34 %G2/M = 31.43 %Debris = 41.73 %G1= 38.71 %S = 35.28 %G2/M = 26.02 %Debris = 72.17 %G1= 58.58 %S = 24.88 %G2/M = 16.54 LY2835219 0 50 100 150 200 250 300 0.02.63.03.54.0 Relative Caspase 3 Activity (%) Log Concentration LY2835219 (nM) A375 A375-R1 M14 M14-R B A A375A375-RV1A375-RV2A375-R1A375A375-RV1A375-RV2A375-R1 Cyclin D1 siRNA Cyclin D1 ←Cyclin D2 Cleaved-PARP Tubulin C
Figure 1 B D DOX ( μ M) C Cell Proliferation (% Con) MCF-7MCF-7/DOX DOX ( μ M) 0.03% 38.79% 0.15% 0.10% 0.20% 0.05%
Date of download: 9/17/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Differential Responses of Human Papillary Thyroid.
Supplemental Figure 1: Chemical structures of fludioxonil and fenhexamid. FludioxonilFenhexamid.
P-ERK β-tubulin VSShh + cyclopamine Supplementary Figure ESM 1a ERK MAP Kinase activity is not affected by Shh pathway activity. Western blot analysis.
Date of download: 7/12/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Inhibition of the Growth of Papillary Thyroid Carcinoma.
Farmer et al Supplementary Figure 1 KU PARP-1 IC 50 = 3.2nM KU PARP-1 IC 50 = 3.4nM KU PARP-1 IC 50 = 730nM a b
Supplementary Table 1 A. B. CI simulations display synergism (CI 1) for the entire spectrum of effect levels (Fa) in the combination of NFV and BZ (right.
親愛的吉姆舅舅： 今天吃完晚餐後，奶奶說，在家 裡情況變好以前，您要我搬到城裡跟 您住。奶奶有沒有跟您說，爸爸已經 好久沒有工作，也好久沒有人請媽媽 做衣服了？ 我們聽完都哭了，連爸爸也哭了， 但是媽媽說了一個故事讓我們又笑了。 她說：您們小的時候，她曾經被您追 得爬到樹上去，真的嗎？ 雖然我個子小，但是我很強壯，
P247. Figure 9-1 p248 Figure 9-2 p251 p251 Figure 9-3 p253.
Supplementary Figure 1: Co-treatment with SAHA and PLX4720 increases the level of a ~50kD fragment of PARP. Whole cell lysates from MM200 and Sk-Mel-28.
Figure1 HER2 SKBr3 PC3 A. SKBr3 cells Figure (µM) Penetratin control % of control (µM)
A B A Stat3:Stat3 Supershift -ST3 Free probe BP1-102 (µM) Stat3:Stat3 % of Cont Supplementary Figures Fig. S1 -
SUDHL16 * * A Granta 519 B SUDHL4 D U2932 E OCI-LY18 C OCI-LY7 * * * * * * * * * * F Title : Synergistic interactions between CFZ and ACY1215 lead to induction.
NPV-BEZ235PKI-587 GDC-0980PD Supplemental Figure S1 Structures of Inhibitors NVP-BEZ235; PKI-587; GDC-0980 and PD
CAMA-1MDA-MB-361 (HER2+)HCC-1569 (HER2+)BT474 (HER2+)HS578TMDA-MB-415 (Luminal)MDA-MB-231MDA-MB-468MDA-MB-436BT20TMDA-MB N10A76NF2V76NE7T47DZR75-1MCF-7MDA-MB-453.
Supplementary Figure S1 Cell index hours Cell index hours MiaPaca-2 cells vehicle ABTL0812 A549 cells.
Figure 1 A B 4µM8µM16µM32µM 0 NS ** *** Infected and 4 µ M STS treated Infected and 32 µM STS treated Mock Infected and 4 µM STS treated Mock Infected.
(hr) Cleaved Caspase-9 Caspase nM Paclitaxel MCF-7 Figure S1a.
Supplementary Table S1 Clinical exposure for palbociclib, fulvestrant and chemotherapeutic agents used in this study. Palbociclib (1)*Paclitaxel (2)*Doxorubicin.
WT Hras G12V WT+TPA Hras G12V +TPA Hras G12V +TPA H&EKi67 Supplementary Fig 1: H&E and IHC staining for Ki67 in sections of mouse skin and papilloma from.
SKOV-3, 48h CaOV-3, 48h BG-1, 48h Concentration (µM) Viable cells (%) SW 43 SW IV-52s SW III-123 SW 43 + SW IV-52s SW 43 SW IV-52s SW III-123 SW 43 + SW.
Journal title: Autophagy Induction by Capsaicin in Malignant Human Breast Cells is Modulated by p38 and ERK Mitogen-Activated Protein Kinases and Retards.
Supplemental data Fig. S1 Figure S1 Circulation bilirubin levels in CRC patients and non-tumor patients. Circulation bilirubin levels in CRC patients were.
PC9 GR_6_AZDR_1 EGFR T790M (8%) PC9 GR_6_AZDR_2 EGFR T790M (13%) NRAS gain PC9 GR_6_AZDR_3 EGFR T790M (12%) NRAS gain PC9 GR_6_AZDR_4 EGFR T790M (13%)
Supplementary Figure 2: PBX1 induces morphological and cytoskeletal changes consistent with differentiation in NB. A) Morphology of SHSY5Y cells. Cells.
Alignment of ERV9-LTR sequences of human genes. Blast search identified candidate genes that contain ERV9 LTRs. The alignment shows the LTR sequences of.
Supplemental Figure S2. Location and H 2 O 2 -dependent binding of RBPs to biotinylated MKP-1 transcripts. (A) Schematic of the MKP-1 mRNA showing the.
Inhibition of SHH signaling enhances Docetaxel efficacy in castration-resistant prostate cancer cells Sierra L. Lawhorne 1,2, Sakthivel Muniyan 1, Parthasarathy.
Supplementary data d a c d ab b Figure S1. Quantification of the Western blot data in figure 4C. The area density of each band was measured with a UVP.
Date of download: 6/22/2016 The Association for Research in Vision and Ophthalmology Copyright © All rights reserved. From: Simultaneous Cell Death.
Supplementary Figure 1. Caspase 8 expression and activation and Fas expression in NSCLC and normal lung cell lines. A Western blot analysis of DR4 and.
THE GENETIC CAUSE OF HAIRY CELL LEUKAEMIA (HCL) AND ITS THERAPEUTIC TARGETING ENRICO TIACCI, M.D. Institute of Hematology, University of Perugia – Italy.
Additional File 1 A. p38 (38 kDa) shRNA Control p53 (53 kDa) shRNA p53 B. Untransfected cells Relative cell no. GFP- vector GFP-Ras G12V Fluorescence Additional.
AP Biology Chapter 12: The Cell Cycle. Checkpoints (Is all going according to plan?)
Supplementary Table S1. List of chemical inhibitors utilized in the current study. Supplementary Information.
10-3 Angle Relationships G2:Properties of 2- dimensional figures.
Compound 5 Structure hLDHA IC ± µM hLDHB IC ± 0.07 µM Supplementary Figure S1.
A B Supplementary Figure 1. (A) Western blots were performed on the three cell lines to analyze the levels of p-ERK, which is a key protein involved in.
Supplementary Figure S1. Determination of the binding mode of the FGFR inhibitor CH /Debio Lineweaver-Burk plot of FGFR1 with different concentrations.
P449. p450 Figure 15-1 p451 Figure 15-2 p453 Figure 15-2a p453.
SIRTs inhibitor: Sirtinol Supplementary Figure S3A Supplementary Figure S3 Sirtinol but not EX527 or PDF-170 significantly enhances ithe cytotoxic and.
Supplementary Figure 1 Supplemental Figure 1. Nogin siRNA potentiates BMP2-induced Smad-dependent BMP- signaling MDA-MB-231 breast cancer cells. MDA-MB-231/BREluc.
Supplementary Figures NormalCRC CRC+5FU CRC+CPT11 100µm S1.
A) Normal learning b) Memantine BAX BAD BCL2 CASP3 pCASP9 Cytosolic BAX BAD BCL2 CASP3 pCASP9 BAX BAD BCL2 CASP3 pCASP9 c) Normal learning + Memantine.
Kudo-Saito, et al Supplementary Figure 1 Leukocytes Lymphocytes Debris Dead cells Human PBMCs.
P-4E-BP1/4E-BP1P-p70 S6K/p70 S6K ND cleaved PARP/PARPLC3II/LC3I Supplementary Figure 1 Relative levels A BC P-Akt/Akt.
Supplementary Fig. 1. (a) Cells were treated with DMSO or with 1 µM of SK-7068 or LAQ824 for 18 hours. They were then fixed with 70% ethanol, stained with.
-SMA α- Tubulin CLIC4 AD-CLIC TGF- Supplementary Figure 1 Supplementary Figure 1. Exogenous CLIC4 expression enhances α-SMA expression.
Supplementary information Figure S1 Parental Mock ANXA1-V5 GAPDH MCF7-EV MCF7-V5 4 5 ANXA1 ANXA1-V5 Tubulin MCF7-parental MCF7-EV MCF7-V A B C ANXA1.
Exon 2 Exon 3 STOP K8β intron Figure S1 …acacaagacagcugcagcag GUAUAGACGGGAAACAGGUGUCUAUCUUGGCCGGCUGGUUACUCAAAUGGGAACAAUGGCGCCACCUUGCUGUCUUUGUAG gcauuagaagaaaaggaugc…
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