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GSEC STUDY: CURRENT DATA ENTRY STATUS (Last Update: October, 2005) Investigators 111 Studies203 Total subjects 73,154 Cases31,977 Controls41,177.

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Presentation on theme: "GSEC STUDY: CURRENT DATA ENTRY STATUS (Last Update: October, 2005) Investigators 111 Studies203 Total subjects 73,154 Cases31,977 Controls41,177."— Presentation transcript:

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7 GSEC STUDY: CURRENT DATA ENTRY STATUS (Last Update: October, 2005) Investigators 111 Studies203 Total subjects 73,154 Cases31,977 Controls41,177 ===========================

8 DISTRIBUTION OF CANCER CASES IN THE DATA SET BY SITE SITE N (%) ----------------------------------------------------------- Lung 10,992 (34) Breast 4878 (15) Bladder3753 (12) Head and neck 2912 (9) Colon 1930 (6) Skin 1632 (6) Leukemia1646 (5) Prostate 873 (3) Ovary148 (1) Uterus 490 (1) Others 2723 (8)

9 Distribution of genetic polymorphisms available in the data-set

10 EXAMPLE OF DATA AVAILABLE THROUGH GSEC NAT 2NAT CYP 1A1 GST M1 GST M3 CYP 2E1 GST T1 GST P1HPX CYP 2D6ADH NQ O CYP 1B1 MTH FR BLADDER Cases 20315626542971010122023374213121111537100 Controls 104064213083514013793012821293103813138100 BREAST Cases 85039699231422753722050124259812603231715433 Controls 112859817423668266431174586858621202831602266 LUNG Cases 1590539415880409761752677928151670143908781130 Controls 337967162191165010842813996534962604221816693556635

11 HuGE – GSEC reviews

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16 Communication of results Publications Yearly e-mail to co-investigators Web site

17 METABOLIC GENE POLYMORPHISM FREQUENCIES IN CONTROL POPULATIONS Seymour Garte, Laura Gaspari, Anna-Karin Alexandrie, Christine Ambrosone, Herman Autrup, Judith L. Autrup, Helena Baranova, Lise Bathum, Simone Benhamou, Paolo Boffetta, Christine Bouchardy, Katja Breskvar, Jurgen Brockmoller, Ingolf Cascorbi, Margie L. Clapper, Christiane Coutelle, Ann Daly, Marco Dell'Omo, Vita Dolzan, Carolyn M. Dresler, Anthony Fryer, Aage Haugen, David W. Hein, Allan Hildesheim, Ari Hirvonen, Ling-Ling Hsieh, Magnus Ingelman-Sundberg, Ivan Kalina, Daehee Kang, Masahiro Kihara, Chikako Kiyohara, Pierre Kremers, Philip Lazarus, Loic Le Marchand, Maria Celeste Lechner, Ester M.M. van Lieshout, Stephanie London, Johannes J. Manni, Christine M. Maugard, Shunji Morita, Valle Nazar- Stewart, Kazumasa Noda, Yoshio Oda, Fritz F. Parl, Roberta Pastorelli, Irene Persson, Wilbert H. M. Peters, Agneta Rannug, Timothy Rebbeck, Angela Risch, Liliane Roelandt, Marjorie Romkes, David Ryberg, Jan Salagovic, Bernadette Schoket, Janeric Seidegard, Peter G. Shields, Edith Sim, Daniel Sinnet, Richard C. Strange, Isabel Stucker, Haruhiko Sugimura, Jordi To-Figueras, Paolo Vineis, Mimi C. Yu, and Emanuela Taioli.

18 Strenghts Weaknesses

19 SOME RESULTS FROM GSEC ON EFFECTS OF METABOLIC GENE VARIANTS Association (O.R.) GSTM1, Smoking and Colorectal CancerNS GSTM1, Head and Neck Cancer1.3 GSTT1, Head and Neck Cancer1.2 GSTM1, Smoking and Lung Cancer1.1 NAT2 and Bladder Cancer1.4 (interaction with smoking)

20 THE WEB SITE (www.gsec.net) Was started at the time the study started Includes updates on data colelction, investigators who joined the group, publications deriving from the project, a medline on genetic susceptibility and cancer It is linked with the HuGE website


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