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GSEC STUDY: CURRENT DATA ENTRY STATUS (Last Update: October, 2005) Investigators 111 Studies203 Total subjects 73,154 Cases31,977 Controls41,177.

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Presentation on theme: "GSEC STUDY: CURRENT DATA ENTRY STATUS (Last Update: October, 2005) Investigators 111 Studies203 Total subjects 73,154 Cases31,977 Controls41,177."— Presentation transcript:

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7 GSEC STUDY: CURRENT DATA ENTRY STATUS (Last Update: October, 2005) Investigators 111 Studies203 Total subjects 73,154 Cases31,977 Controls41,177 ===========================

8 DISTRIBUTION OF CANCER CASES IN THE DATA SET BY SITE SITE N (%) Lung 10,992 (34) Breast 4878 (15) Bladder3753 (12) Head and neck 2912 (9) Colon 1930 (6) Skin 1632 (6) Leukemia1646 (5) Prostate 873 (3) Ovary148 (1) Uterus 490 (1) Others 2723 (8)

9 Distribution of genetic polymorphisms available in the data-set

10 EXAMPLE OF DATA AVAILABLE THROUGH GSEC NAT 2NAT CYP 1A1 GST M1 GST M3 CYP 2E1 GST T1 GST P1HPX CYP 2D6ADH NQ O CYP 1B1 MTH FR BLADDER Cases Controls BREAST Cases Controls LUNG Cases Controls

11 HuGE – GSEC reviews

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16 Communication of results Publications Yearly to co-investigators Web site

17 METABOLIC GENE POLYMORPHISM FREQUENCIES IN CONTROL POPULATIONS Seymour Garte, Laura Gaspari, Anna-Karin Alexandrie, Christine Ambrosone, Herman Autrup, Judith L. Autrup, Helena Baranova, Lise Bathum, Simone Benhamou, Paolo Boffetta, Christine Bouchardy, Katja Breskvar, Jurgen Brockmoller, Ingolf Cascorbi, Margie L. Clapper, Christiane Coutelle, Ann Daly, Marco Dell'Omo, Vita Dolzan, Carolyn M. Dresler, Anthony Fryer, Aage Haugen, David W. Hein, Allan Hildesheim, Ari Hirvonen, Ling-Ling Hsieh, Magnus Ingelman-Sundberg, Ivan Kalina, Daehee Kang, Masahiro Kihara, Chikako Kiyohara, Pierre Kremers, Philip Lazarus, Loic Le Marchand, Maria Celeste Lechner, Ester M.M. van Lieshout, Stephanie London, Johannes J. Manni, Christine M. Maugard, Shunji Morita, Valle Nazar- Stewart, Kazumasa Noda, Yoshio Oda, Fritz F. Parl, Roberta Pastorelli, Irene Persson, Wilbert H. M. Peters, Agneta Rannug, Timothy Rebbeck, Angela Risch, Liliane Roelandt, Marjorie Romkes, David Ryberg, Jan Salagovic, Bernadette Schoket, Janeric Seidegard, Peter G. Shields, Edith Sim, Daniel Sinnet, Richard C. Strange, Isabel Stucker, Haruhiko Sugimura, Jordi To-Figueras, Paolo Vineis, Mimi C. Yu, and Emanuela Taioli.

18 Strenghts Weaknesses

19 SOME RESULTS FROM GSEC ON EFFECTS OF METABOLIC GENE VARIANTS Association (O.R.) GSTM1, Smoking and Colorectal CancerNS GSTM1, Head and Neck Cancer1.3 GSTT1, Head and Neck Cancer1.2 GSTM1, Smoking and Lung Cancer1.1 NAT2 and Bladder Cancer1.4 (interaction with smoking)

20 THE WEB SITE (www.gsec.net) Was started at the time the study started Includes updates on data colelction, investigators who joined the group, publications deriving from the project, a medline on genetic susceptibility and cancer It is linked with the HuGE website


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