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1 Life Analytical Chemistry-Molecular Imaging (MI): Magnetic Resonance Imaging (MRI) Gaolin Liang (梁高林), Ph. D. Professor, Ph. D. Advisor Department of.

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Presentation on theme: "1 Life Analytical Chemistry-Molecular Imaging (MI): Magnetic Resonance Imaging (MRI) Gaolin Liang (梁高林), Ph. D. Professor, Ph. D. Advisor Department of."— Presentation transcript:

1 1 Life Analytical Chemistry-Molecular Imaging (MI): Magnetic Resonance Imaging (MRI) Gaolin Liang (梁高林), Ph. D. Professor, Ph. D. Advisor Department of Chemistry University of Science and Technology of China

2 2 Magnetic resonance imaging is a relatively new technology. The first MR image was published in 1973 [2][3] and the first cross-sectional image of a living mouse was published in January [4] The first studies performed on humans were published in [5][6] By comparison, the first human X-ray image was taken in [2][3] [4] [5][6]X-ray 2. Lauterbur PC (1973). "Image Formation by Induced Local Interactions: Examples of Employing Nuclear Magnetic Resonance". Nature 242: 190–191. doi: /242190a0. Naturedoi /242190a0 3. Filler AG (2010). "The history, development, and impact of computed imaging in neurological diagnosis and neurosurgery: CT, MRI, DTI". Internet Journal of Neurosurgery 7 (1). Internet Journal of Neurosurgery 4. Lauterbur PC (1974). "Magnetic resonance zeugmatography". Pure and Applied Chemistry 40: 149–157. doi: /pac Pure and Applied Chemistrydoi /pac Damadian R, Goldsmith M, Minkoff L (1977). "NMR in cancer: XVI. Fonar image of the live human body". Physiological Chemistry and Physics 9: 97–100.Physiological Chemistry and Physics 6.Hinshaw DS, Bottomley PA, Holland GN (1977). "Radiographic thin-section image of the human wrist by nuclear magnetic resonance". Nature 270: 722–723. doi: /270722a0.Naturedoi /270722a0 History of MRI

3 Nobel Prize in Physiology or Medicine-MRI Paul Christian Lauterbur (May 6, 1929 – March 27, 2007) University of Illinois at Urbana-Champaign. Chemist.University of Illinois at Urbana-Champaign Sir Peter Mansfield (born 9 October 1933), University of NottinghamUniversity of Nottingham. Physicist. * Nobel Prize in 1952 in Physics, NMR Anthony J. Leggett Physics,absent Alexei A. Abrikosov, Physics,superconduct Peter Agre, Chemistry, water channels Roderick MacKinnon, Chem,Ion channels Robert F. Engle III, Economic Clive W.J. Granger, economic

4 4 Basic Principles of MRI

5 5 Basic Principles of MRI: Proton

6 6

7 7

8 8 Others: 64-Gd; 26-Fe; 13-C; 19-F; 31-P; 23-Na

9 9 Basic Principles of MRI FID

10 10 T2 (S=S 0 exp(-t/T2)

11 11 T1 (S=S 0 (1-exp(-t/T1))) 1/T1=R1*C+1/T1 0

12 12 Introduction- Principle of MR T1 contrast agent

13 13 核磁共振显像与造影剂

14 14 核磁共振显像与造影剂 SPIO ,内二显, Resovist ® 马根维显, magnevist ® 多它灵, dotarem ®

15 15 Gaolin Liang 15 NPs for MRI: Inorganic crystals (SPIO) Cunningham, C. H.; Arai, T.; Yang, P. C.; McConnell, M. V.; Pauly, J. M.; Conolly, S. M. Magnetic Resonance in Medicine 2005, 53,

16 16 NPs for MRI: Nanaoparticle-assembled capsules (NACs) Plush, S. E.; Woods, M.; Zhou, Y. F.; Kadali, S. B.; Wong, M. S.; Sherry, A. D. Journal of the American Chemical Society 2009, 131,

17 17 NPs for MRI: Metal-organic-framework (MOF) Rowe, M. D.; Chang, C. C.; Thamm, D. H.; Kraft, S. L.; Harmon, J. F.; Vogt, A. P.; Sumerlin, B. S.; Boyes, S. G. Langmuir 2009, 25,

18 18 01/22/10 NPs for MRI: Gadolinium liposomes Ghaghada, K. B.; Ravoori, M.; Sabapathy, D.; Bankson, J.; Kundra, V.; Annapragada, A. PLoS One 2009, 4, Article No.: e7628.

19 19 01/22/10 NPs for MRI: Emulsion nanoparticles Flacke, S.; Fischer, S.; Scott, M. J.; Fuhrhop, R. J.; Allen, J. S.; McLean, M.; Winter, P.; Sicard, G. A.; Gaffney, P. J.; Wickline, S. A.; Lanza, G. M. Circulation 2001, 104,

20 20 01/22/10 What we have done Liang, G. L.; Ren, H. J.; Rao, J. H. Nature Chemistry 2010, 2,

21 21 Our design and results Liang, G. L.; et al; Rao, J. H.* Angew. Chem. Int. Ed. 2011, 50:

22 22 Our design and results

23 23 Our design and results

24 24


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