7Liver Fibrosis (METAVIR) Case ReportFibroScan® (kPa)8.89.614.6Liver Fibrosis (METAVIR)Previous studies showed that ls values strongly correlate with Metavir score for hepatitis c as seen in this slide. The studies determine that ls cut offs for f1/f2/f3/f4 stages are 7.1, 9.5 and 12.5F0-F1F2F3F4Ziol et al, Hepatology 20057
8Case Report – Question 1 FibroScan® is correct ? Liver Biopsy ? What could we conclude ?FibroScan® is correct ?Liver Biopsy ?Another non invasive test ?
18STEATOSIS AND LIVER STIFFNESS P < 0.0016.28.5Nao tem impacto negativo na performance diagnosticaCardoso et al [abstract]. Hepatology International 2010
19STEATOSIS DETECTION USING CAP Beaugrand et at. JVH 2011
20STEATOSIS DETECTION USING CAP T = 236 dB/m, Se=0.83, Sp=0.73T = 255 dB/m, Se=0.94, Sp=0.63T = 282 dB/m, Se=0.95, Sp=1Cardoso et al, AASLD 2010
21Case Report Take-Home Messages FibroScan® and some serum markers are good tools for non invasive evaluation of liver fibrosis and can avoid liver biopsy in many cases.However discordance can occurs in 25%10% of the discordances do not have an explanationLiver biopsy persist as the best standart for these cases
24Castera et al, J Hepatol 2008; 48: 835-47 11/04/2017Case Report10 validated measuresSuccess rate > 60%Results are expressed in kPa.The medianOnly procedures with 10 validated measurements and a success rate of at least 60% and a IQR < 30% of the median value are considered reliable.11.20.914.6IQR < 30% medianCastera et al, J Hepatol 2008; 48:24