Introduction Magnetic nanoparticles (1) high surface area (2) affinity for the specific analytes (3) efficient extraction of analytes (4) easily oxidized in air
Introduction CoC−NH2 nanomagnets (1)Graphene has outstanding physical,Graphene and chemical properties (2) increase ion yields (3) affinity for the specific analytes
Introduction Graphene (1)maximum UV absorption at 270 nm (2)high surface area (3) good energy transfer ability (4) less interference of matrix-related ions
Introduction polyfluorinated compounds (PFCs)PFCs Compounds in this class were firstproduced in the 1940s and1950s. By the early 2000s, when it became apparent that PFCs were broadly distributed in the environment. Perfluorooctanesulfonic acid (PFOS)PFOS
PFOS An increase in hepatocellular adenomas and thyroid follicular cell adenomas was observed in rats exposed to high levels of PFOS in their food the half-life of PFOS in humans is approximately 5.4 years
Characterization of Modified and Unmodified CoC Nanomagnets. Unmodified CoC Nanomagnets.
Characterization of Modified and Unmodified CoC Nanomagnets. Functionalization of carbon-coated magnetic nanobeads with chlorobenzene and nitrobenzene and reduction of the nitro groups to amino groups with elemental sulfur. SDS=sodium dodecylsulfate
Characterization of Modified and Unmodified CoC Nanomagnets.
Affinity SALDI-MS Using Modified and Unmodified CoC−NH 2 Nanomagnets. angiotensin II m/z: 1047
Affinity SALDI-MS Using Modified and Unmodified CoC−NH 2 Nanomagnets. Graphene oxide (SY = 0.38) a hybrid film of poly(allylamine hydrochloride)- functionalized graphene oxide and gold nanoparticles (SY = 0.78)
Affinity SALDI-MS Using Modified and Unmodified CoC−NH 2 Nanomagnets.
Extraction of PFOS from Water Using CoC−NH 2 Nanomagnets and SALDI-MS Detection.
CONCLUSIONS 1.We have demonstrated that CoC−NH2 nanomagnets work well in tandem with SALDI-MS as a LDI-assisting material and for the extraction/enrichment of analytes from dilute solution. 2.The benzylamine surface modification of the CoC nanomagnets was shown to increase the ion yield of angiotensin II and decrease ion fragmentation of benzylpyridinium ions. 3.SALDI-MS using CoC−NH2 nanomagnets enabled the detection of various small molecule drugs,but the detection of the small acidic drug molecules acetylsalicylic acid and ibuprofen were not achieved with this approach. 4.The detection sensitivities of PFCs were 0.1 ppt for PFOS (C8), 10 ppt for PFHxS (C6), and 10 ppt for PFBS (C4). 5.In future work, it may be interesting to detect aromatic compounds as aqueous environmental samples using affinity SALDI-MS with CoC−NH2 nanomagnets.
CONCLUSIONS In fact, preliminary experiment indicated that the detection of pentachlorophenol (20 ppb) in water, was accomplished by the use of affinity SALDIMS with CoC−NH2 nanomagnets.