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Wie Halbleitertechnologie die Medizintechnik revolutioniert Design & Elektronik Developers' Forum: "Embedded Goes Medical" Leipzig, September 2009 Matthias.

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Presentation on theme: "Wie Halbleitertechnologie die Medizintechnik revolutioniert Design & Elektronik Developers' Forum: "Embedded Goes Medical" Leipzig, September 2009 Matthias."— Presentation transcript:

1 Wie Halbleitertechnologie die Medizintechnik revolutioniert Design & Elektronik Developers' Forum: "Embedded Goes Medical" Leipzig, September 2009 Matthias Feulner Marketing Manager

2 2 Semiconductors Impact 1980s1990s2000 and beyond Computing transformed Communications transformed Healthcare transformed Computing revolution Communications revolution Healthcare revolution

3 3 Single-chip GPS Wireless LAN Bluetooth ® + FM Single Chip GSM/GPRS Single Chip LoCosto ™ EDGE single-chip eCosto ™ Making devices smaller…

4 4 …, more personal… Chronic Disease Management GSM/GPRS Bluetooth / BLE Bluetooth / BLE Zigbee / Weight scale Blood pressure monitor Smart bandage Vital Signs Monitoring 800 MHz / 900 MHz ISM 2.4GHz ISM (Zigbee/BT/ /ULP) Weight Management

5 5 Smart Bandage Body worn monitoring devices Chip + Sensor + printed battery in a low cost DISPOSABLE package Real time Intelligent Continuous Wireless … sensing and diagnosing For in-hospital and out-of-hospital continuous wireless monitoring of vital signs and other physiological data directly off the body Patient monitor EVOLUTION Wireless portable patient monitor ECG / Heart rate Temperature REVOLUTION Respiration Location Activity / Motion

6 6 ECG EEG Blood oxygen (pulse oximeter) Blood pressure Temperature Ventilation/ respiration Defibrillators Implantable devices Diagnostic, patient monitoring and therapy Innovation Across all Medical Segments Digital thermometers Blood glucose monitor Blood pressure monitor Insulin pumps Heart rate monitors Audiology (digital hearing aids) Consumer medical devices Laboratory equipment Dialysis machines Analytical instruments Surgical instruments Dental instruments Ultrasound CT MRI X-Ray Other imaging (nuclear, positron emission tomography) Medical imaging Medical instruments Doctor’s office + Patient’s home Uncomfortable Comfortable + Radiology center In the field Laboratory Innovation

7 7 Addressing the Major Challenges Smaller & Lighter More Power-Efficient More Cost-Efficient More Connected More Portable

8 8 Addressing the Major Challenges - Consumer Medical Case Smaller & Lighter More Power-Efficient More Cost-Efficient More Connected More Portable

9 9 Consumer Medical Devices - Achieving Highest Level of Integration and Cost Efficiency ADC Bio Sensor VRef MCU LCD Display Op Amp DAC Signal Processing LCD Driver Op Amp MSP430FG439

10 10 Heart rate monitor based on SoC - Achieving Highest Level of Integration Single chip SoC integration results in:  over 50% size reduction (from 8+ chips to a single MSP430FG439 micro controller)  ~50% cost reduction on semiconductors, circuit board and mechanical housing  10x increased battery life time, allowing lifetime sealed medical units with small coin cell batteries.

11 11 Addressing the Major Challenges - Portable Diagnostics & Therapy Case Smaller & Lighter More Power-Efficient More Cost-Efficient More Connected More Portable

12 12 Portability for ECG Systems Portable ECG images courtesy of Corscience

13 13 Protect Amp Protect RLD Protect Amp ProtectAmp ProtectAmp ProtectAmp Protect Amp ProtectAmp ProtectAmp R(RA) L(LA) F(LL) C1(V1) C2(V2) C3(V3) C4(V4) C5(V5) C6(V6) ProtectAmp Lead Off Calibration Temp Ref Lead Selection IA BT  C MSP430 USB SD BUTTON I/F Amp RS23 2 CF Charge r r PSU Monitor Disp Lamp Disp Lamp ++ RTC PACE DETECT 3x Comparator Traditional 8-Channel ECG System Solution 24-bit   ADC Switching / Mux Switching / Mux Integrated 8-Channel ECG System Solution Integration results in:  ~50% size reduction  ~20% cost reduction  ~20% power reduction

14 14 Integrated ECG Solution Demonstrated Integrated 16ch ADC ADS1258

15 15 Addressing the Major Challenges - Portable Ultrasound Case Smaller & Lighter More Power-Efficient More Cost-Efficient More Connected More Portable

16 16 Bringing Ultrasound to the Point-of-Care Tsunami Military Mt. Everest Images courtesy of Sonosite

17 17 Integration Steps for Portable Ultrasound Transmit Beamformer Front End Back End Mid Receive Beamformer Control Unit Preprocessing Spectral Doppler Processing B Mode Processing Color/Power Doppler Processing Scan Conversion Post Processing Clocking LPW RS232 USB Common Interfaces Power Backlight Touchscreen Memory Interfaces MMC/SDIO IDE/ATA Ultrasound OS/UI CW (analog) Beamformer Tx Buffer Amp Passive LPF FET Driver Embedded Processing ADC DAC Audio Amp ADC Analog Front End LNAVCA Low Pass Filter PGA Amp + Filter Amp Stage T/R Switches HV MUX Transducer Analog signal chain

18 18 Transmit Beamformer Front End Back End Mid Receive Beamformer Control Unit Preprocessing Spectral Doppler Processing B Mode Processing Color/Power Doppler Processing Scan Conversion Post Processing Clocking LPW RS232 USB Common interfaces Power Backlight Touchscreen Memory interfaces MMC/SDIO IDE/ATA Ultrasound OS/UI CW (analog) Beamformer Tx Buffer Amp Passive LPF FET Driver Embedded processing ADC DAC Front end High- Performance DSP Back end Audio Amp Mid High- Performance DSP ADC Analog Front End LNAVCA Low Pass Filter PGA Amp + Filter Amp Stage DSP SoC/Apps. processor High- Performance DSP T/R Switches HV MUX Transducer Analog signal chain Integration Steps for Portable Ultrasound

19 19 Ultrasound Receiver Front-End Integration Path 15mm 9mm AFE5805EVM

20 20 Phantom Image Mimicking Vessel Reflectors Mimicking Tissue Portable Ultrasound Demonstrator Implemented 32 channels Tx & Rx on Analog Front End Board AFE5805 TX734 DAC902 CDCE62005 DM6446 Analog Front End Board Digital Processing Board

21 21 What are the Major Challenges? - Wireless Medical Sensors Case (BAN / AAL) Smaller & Lighter More Power-Efficient More Cost-Efficient More Connected More Portable

22 22 Goal: Reduce Wires for Patient Comfort Three electrodes on head Two electrodes on forehead One electrode next to each eye Two electrodes under mouth Two electrodes on each leg A pulse oximeter on the finger A chest belt for respiration monitor A breathing tube …all collected on the blue box From the blue box, a very thick cable ran to the computer that collected all the signals Now go to sleep … 14-year old David during a sleep test

23 23 Solution: Wireless Connected Vital Sensors Telematik new sensor concepts By microsystems technology Smart Sensors Hardware: Universal platform for the transfer of biosignals Software: Interface standards Pulsoximeter continous Monitoring 3 channelsECG Scales Transfer of data via SMS Peak-Flowmeter Sphygmomanometers Thermometers The interconnection of new sensors with Courtesy of FZI Karlsruhe

24 24 Application in Experimental Monitoring Jacket Continous measurement of Blood pressure change Activity sensor ECG Wireless communication (BlueTooth) Electronics Courtesy of FZI Karlsruhe

25 25 Potential Wireless Standards Passive RFID Active RFID / Zigbee Bluetooth Low Energy Bluetooth IEEE b IEEE a/g IEEE n UWB Sub-1GHz ISM } Wireless Connectivity for Medical applications

26 26 What is LE Bluetooth? LE – Low Energy Single mode device (BTLE only) Dual mode device (GTLE+Bluetooth BR/EDR) Simplified version of Bluetooth optimized for low power Low average power – quick initialization of links Low peak current – suitable for coin cell usage Wireless Connectivity for Medical applications CC2540

27 27 BT Classic vs. BT LE BT Classic (BR/EDR)Bluetooth Low Energy (BLE ) 1, 2 or 3 Mbps 1 Mbps 5-10 m GHz GFSK (BR), PSK (EDR) GFSK (index 0.5) Star + Piconet Pure Star (no piconet) Master send page, Slave scan Master scans, slave advertises Voice (SCO), Data (ACL) Data (ACL) Pseudo random XOR sequence AES-CCM (NIST approved) Data transfer once a minute: 70uA Paired – not connected 320uA Data transfer once a minute: 53uA Paired – not connected: 190uA Data transfer once a minute: 70uA Paired – not connected: 320uA Data transfer once a minute: 7uA Paired – not connected: 4uA Init connection: 35mA for 10mS, ~10mA for <100mS Init connection: 17mA for 128uS Shared BR/EDR/ULP HCI (in dual-mode) Data rate Range ISM bandwidth Modulation Topology Device Discovery Packet Formats Security Average Power Consumption (Dual Mode) Average Power Consumption (Single Mode) Peak Current Consumption (peak) HCI Sensitivity (BER=0.1%) Spec: -70 dbm BL6450: -95 dbm (BR) Spec: -70 dbm BL6450: slightly better than -92 dbm CC2540 Wireless Connectivity for Medical applications

28 28 BLE Enabled by CC2540 System-on-a-chip (SoC) Wireless Connectivity for Medical applications Chronic Disease Management Weight scale Blood pressure monitor Smart bandage Vital Signs Monitoring Weight Management CC2540 BLE evaluation kit with USB dongle CC2540 BLE coin cell demo

29 29 Health Care Revolution


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