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The Endogenous Cannabinoids and the Control of Drug Craving Alexandros Makriyannis, Director
9 / 8 -THC 9 -THC / 8 -THC 9 -tetrahydrocannabinol 8 -tetrahydrocannabinol
Medicinal Uses for Cannabinoids AnalgesicAnticonvulsiveSedativeAntidepressiveHypnoticAntiasthmaticImmunomodulation Memory Enhancing Anesthetic Birth Control Appetite Stimulation Antipyretic Neuropathic Pain AntiemeticAntirheumaticAntimigraineAntineuralgic Reduction of Fatigue
Two Cannabinoid Receptors: CB1 & CB2 174 179 CB2 e1 e2 e3 i1 i2 i3 Extracellular 472 amino acids 360 amino acids
Endogenous Cannabinoid Receptor Ligands Anandamide2-Arachidonylglycerol Palmitylethanolamide CB2 72279 CB1CB2CB1 K i (nM) 58 145
Cannabinoid Targets for Drug Discovery
Nature Neuroscience, Vol. 2, 4, 304-5 (1999)
Retrograde Signaling & the Cannabinergic System
Purification of FAAH MW: 63 kDaMW: 63 kDa pI: 6.2pI: 6.2208144 87 44.1 32.7
Inhibition of [ 3 H]anandamide accumulation by AM 404 and AM403 Science, Vol. 277, 1094-97 (1997) AM404 AM403
Cannabinergic Ligands O N H OH AM 251 Anandamides (AEA’s) AM356 1,5-Biarylpyrazoles 8 -THC Aminoalkylindoles(AAI’s) Non-Classical (NCC’s) AM630 OH OH O H Classical (CC’s) CP55,940
Spinal Endocannabinoids and CB 1 Receptors Mediate C-Fiber–Induced Heterosynaptic Pain Sensitization Pernia-Andrade et al. (2009) Science 325:
Mechanisms of Endocannabinoid Inactivation: Functional Consequences Daniele Piomelli University of California, Irvine SfN, November 7, 2003.
Endocannabinoid signaling and stress in CVS Thangam Venkatesan, MD Associate Professor of Medicine Division of Gastroenterology and Hepatology Medical.
Revised Model of Endocannabinoid Signaling. Cannabinoids Medically and traditionally used for thousands of years Active compound of marijuana (D 9 -THC)
Chapter 14 Opener State initiatives such as the 2012 Oregon Cannabis Tax Act are aimed at decriminalizing or even legalizing the possession and use of.
Cannabis: The plants used for making marijuana Plant features Annual Dioecious Flowering Wind-pollinated.
Potential Pharmacotherapy for Cannabis Use Disorders Leslie H. Lundahl, Ph.D. Department of Psychiatry and Behavioral Neurosciences Wayne State University.
Exercise and pain Walter R. Frontera, MD, PhD Professor and Chair (Inaugural) Department of Physical Medicine and Rehabilitation Vanderbilt University.
Effects of Cannabanoids on the brain! Delta 9-THC.
A Drug from the Cannabis Field Appears to Protect From Seizure Related Brain Damage Long C 1, Quizon PMP 1, Romine H 1, Kelly W 1, Naidoo V 1, Ruiz S 1,
Cannabinoid use in Cancer Patients PAS 646 Univ. of Kentucky Ryan Filiatreau.
Psych 181: Dr. Anagnostaras Lec 10: Marijuana. cannabinoids Marijuana and cannabinoids Cannabis sativa, hemp One of earliest non-food plants cultivated.
Receptors and transduction 2 References: Chapter 12 – Neuron by Levitan & Kaczmarek OR Chapter 6 – Neuroscience by Purves et al 1)Metabotropic glutamate.
Medical Marijuana Helen Jang, Tara Hooley, David Hoang, Noel Kwok, John K Rhee, & Janelle Odakura DFM 655 Fall 2014.
CB1 expression in DRGs. Pharmacological tools Selectivity and affinity of CB1 agonists are suboptimal (Pertwee 2009)
Cannabis and Schizophrenia. Major Constituents of Cannabis The two major substances found in cannabis include tetrahydrocannabinol (THC) and cannibidiol.
The Nervous System-Part II Neurotransmitters. Action Potentials Target Neurotransmitter Release.
A cannabinoid hypothesis of Schizophrenia Cognitive Impairments Due to Dysregulation of the Endogenous Cannabinoid System.
Marijuana-The Basics marijuana+works&n=780d08af&p2=^Y6^xdm003^S11497^us& pn=2&ptb=824B6CAC-6C85-494C-8E43-
Endocannabinoids An Emotional Buffer?. Lipid neuromodulators and hormones Made from Membrane phospholipids Synthesized On Demand stimulated.
E4: Neurotransmitters and Synapses DnlNjuguna ~ DAIS.
E.4 Neurotransmitters and Synapses. E4.1 Postsynaptic Responses Pre-synaptic neurons can inhibit or excite the post synaptic neuron by releasing excitatory.
Drugs. Say _Know_ to. Food Vitamins Minerals Aspirin Chocolate Coffee Alcohol Nicotine.
Drug Types Types –Psychoactive – alters mood or consciousness; affects neural functioning –Non-psychoactive – e.g., antibacterial Classes of psychoactive.
ENDOCANNABINOID REGULATION OF ALTERNATIVE MICROGLIA ACTIVATION IN MULTIPLE SCLEROSIS CAITLIN JAGLA.
Neurotransmitters (and other Mood Changers). All Natural – All Organic Neurotransmitters responsible for: reward pathways, mood, sleep, muscle control,
The Nervous System-Part II Neurotransmitters, Drugs and Disease of the Brain.
Figure 3.16 Different Types of Synaptic Connections
Overview of the striatum
Source: International Chair on Cardiometabolic Risk Role of the Dysregulated Endocannabinoid System in Determining Cardiometabolic.
The Endocannabinoid System as a Pharmacologic Target in Treating Obesity Lauren Kerrick Braden Advisor: Dr. Hadley Spring 2007.
Efficacy in CB 1 Cannabinoid Receptor Signal Transduction. NIDA November, 2003 Allyn Howlett, Ph.D. Neuroscience/Drug Abuse Research Program J. L. Chambers.
CHOCOLATE How It affects the human body. Popularity The average American citizen eats over 12 pounds of chocolate per year Chocolate Industry claims.
1 Vol. 03. p Vol. 03. p Vol. 03. p.16.
1 Vol. 01. p Vol. 01. p Vol. 01. p.14.
1 Vol. 01. p Vol. 01. p Vol. 01. p.20.
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Cannabis Prof. Suleiman Olimat.
Returning Cannabis to the Medicine Cabinet? Professor Les Iversen University of Oxford.
Group 3 Our Objective: We made a molecule to disrupt marijuana's effects.And try to cure a person with severe addiction to this drug.
Simon Duri Xixi Hong Joseph Lustig Aleksandra Porebska.
Psychoactive Plants Hallucinogens - I: Marijuana.
Research themes 1.Describe the main scientific question and the big scientific picture you address. 2.Why is it important? 3.The knowledge gap (i.e. unanswered.
Pharmacology of central Neurotransmitters Prof. Yieldez.
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