Presentation on theme: "Why are new drugs and cheaper, more user friendly regimes needed?"— Presentation transcript:
1Why are new drugs and cheaper, more user friendly regimes needed?
2"Tuberculosis, whether caused by drug-susceptible or drug-resistant strains, rarely made even medical headlines, in part because its importance as a cause of death continued to decline in areas in which headlines are written.”Keshavjee and Farmer, NEJM, 2012*And what TB crisis?* Tuberculosis, Drug Resistance, and the History of Modern Medicine. Salmaan Keshavjee and Paul Farmer. N Engl J Med Sep 6;367(10):931-6.
3Cost-ineffective?“…selective primary health care and ‘cost-effectiveness’ have shaped an anemic response to the ongoing global pandemic.”**Tuberculosis, Drug Resistance, and the History of Modern Medicine. Salmaan Keshavjee and Paul Farmer. N Engl J Med Sep 6;367(10):931-6.
5SA : MDR-TB already >55% of TB budget! Financing the scale-up of MDR-TB prevention and Treatment. Katherine Floyd, Stop TB, WHO. Ministerial meeting. Beijing, China, 2009
6The perception among the majority is that we are not at risk of being infected by TB. This assumption is deeply flawed. Dr Madhukar Pai, India Tribune, 29 October 2012The RNTCP needs to think beyond treatment of drug-resistant TB, and focus on preventing a major epidemic. In the case of drug-resistant TB, an ounce of prevention is definitely better than a pound of cure
7Care for the carer±1/100: number of South Africans diagnosed with TB last year (WHO, 2012).3x: increased rate of TB among Health Care Workers globally (Baussano, 2011).6.3%: confirmed drug-resistance among occupational TB cases at Tygerberg Hospital (Data: ).5.56x higher incidence rate of MDR- and XDR (O’Donnell, 2010)Means 3/100 HCW’s could be diagnosed with TB every yearAt least 1/16 could have MDR-TB or worse
8Lucky and thankful…Dalene got her life back, she can still hear, and can even practice as a clinician again…what next?TB PROOF
12Anyone can get TB Nobel peace prize TB survivors “UBUNTU” – I am because we are We are all in this together!
13SA record: 114m in one breath! HOPE: Life after TBSA record: 114m in one breath!
14Thank you! Physicians: Paul Willcox CBTBR/Genetics: Gerhard Walzl Andreas DiaconSimon SchaafTony BiebuyckJantjie TaljaardKeertan DhedaPharmacologyGary MaartensElsimé KiftJeannine Du BoisSupportiveJustus Apffelstaedt - SurgeryMou Manie - RheumatologyAnton Doubell - CardiologyMark Abelson – CardiologyProf Loock – Ear, nose and throatRadiologySucari VlokArthur MaydallJan LotzOccupational Health/TBHJack MeintjiesSr SamuelsSr ArendseMatodzi Mukosi - superElmarie MalekMariana KrugerSAMA - Daniel MadibaCBTBR/Genetics:Gerhard WalzlBelinda KrielDaleen KrielRob WarrenTommie VictorSoraya Bardien-KrugerLizma StreicherTibotec/Janssen:David McNeeleyGilles van BaarNHLSMariza HoffmanHaematology and Microbiology TechnologistsAudiology:Rene VisagieSharon PitheyTygerberg AudiologistsCAPRISANesri PadayatchiKogieleum NaidooTB PROOFAngela DramowskiBart WillemsHeena NarotamHelene-Mari van der WesthuizenKoot KotzeTreatment Action GroupThank you!
15“The momentum to break this disease is in real danger “The momentum to break this disease is in real danger. We are now at a crossroads between TB elimination within our lifetime, and millions more TB deaths.” Dr Mario Raviglione; Director of the WHO Stop TB Department; 17 October 2012Questions?