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Copyright (c) by W. H. Freeman and Company Chapter 22 Integrating Cells into Tissues.

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Presentation on theme: "Copyright (c) by W. H. Freeman and Company Chapter 22 Integrating Cells into Tissues."— Presentation transcript:

1 Copyright (c) by W. H. Freeman and Company Chapter 22 Integrating Cells into Tissues

2 Copyright (c) by W. H. Freeman and Company 22.0 Schematic overview of the types of molecules that bind cells to each other and to the extracellular matrix Figure 22-1

3 Copyright (c) by W. H. Freeman and Company 22.1 There are five principal classes of cell-adhesion molecules (CAMs) Figure 22-2

4 Copyright (c) by W. H. Freeman and Company 22.1 Cadherins mediate Ca 2+ -dependent homophilic cell-cell adhesion

5 Copyright (c) by W. H. Freeman and Company 22.1 N-CAMs mediate Ca 2+ -independent homophilic cell-cell adhesion Figure 22-3

6 Copyright (c) by W. H. Freeman and Company Regulação da ligação de N- CAM por sialização

7 Copyright (c) by W. H. Freeman and Company 22.1 Selectins and other CAMs participate in leukocyte extravasation Figure 22-4

8 Copyright (c) by W. H. Freeman and Company 22.1 Cadherin-containing junctions connect cells to one another Figure 22-5

9 Copyright (c) by W. H. Freeman and Company A Matriz Extracelular (ECM) zPresente em todos os tecidos yOrganiza as células em tecidos yCoordena a função as células yProvidencia um caminho para a migração celular yMoléculas na matriz activam vias de trasdução que regulam o crescimento, divisão e expressão génica das células yAs células interagem com a ECM através de CAM xPrincipalmente integrinas xTambém selectinas e proteoglicanos

10 Copyright (c) by W. H. Freeman and Company 22.2 Integrins mediate weak cell-matrix and cell-cell interactions Cell-matrix adhesion is modulated by changes in the activity and number of Integrins (plaquetas; maturação S.I.) De-adhesion factors promote cell migration and can remodel the cell surface Desintegrinas (pequenos péptidos com RGD) Proteases que degradam a ECM Matrix specific Metaloproteinases Fibrinogen

11 Copyright (c) by W. H. Freeman and Company 22.2 Integrin-containing junctions connect cells to the substratum Figure 22-9

12 Copyright (c) by W. H. Freeman and Company 22.3 Collagen: the fibrous proteins of the matrix

13 Copyright (c) by W. H. Freeman and Company 22.3 The basic structural unit of collagen is a triple helix Figure Collagen fibrils form by lateral interactions of triple helices Gly-Pro-X Glycine (R=H) Proline

14 Copyright (c) by W. H. Freeman and Company 22.3 The side-by-side interactions of collagen helices are stabilized by covalent bonds Figure 22-12

15 Copyright (c) by W. H. Freeman and Company 22.3 Assembly of collagen fibers begins in the ER and is completed outside the cell Figure 22-14

16 Copyright (c) by W. H. Freeman and Company 22.3 Mutations in collagen reveal aspects of its structure and biosynthesis Figure 22-15

17 Copyright (c) by W. H. Freeman and Company 22.3 Collagens form diverse structures Figure 22-16

18 Copyright (c) by W. H. Freeman and Company 22.4 Fibronectins bind many cells to fibrous collagens and other matrix components


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