Presentation on theme: "THE BIOLOGY OF CANCER A group of diseases identified by uncontrolled cell growth and proliferation VirusesGenetic make-upImmune statusRadiationCarcinogens."— Presentation transcript:
THE BIOLOGY OF CANCER A group of diseases identified by uncontrolled cell growth and proliferation VirusesGenetic make-upImmune statusRadiationCarcinogens Normal cell growth Abnormal cell growth
DEVELOPMENT OF CANCER First MutationSecond Mutation Third MutationFourth Mutation Tumor formationAngiogenesisInvasionMetastasis
PROGRESSION OF CANCER Hyperplasia Dysplasia In situ cancer Invasive cancer Mutation
THE CELL CYCLE ProphaseMetaphaseAnaphaseTelophase M G0 G2 Mitosis G1 S Cell increases in size & produces RNA and synthesizes proteins Cell arrest & absence of cell division DNA synthesis Production of new proteins for cell division G1 + S + G2 = Interphase
CELL CYCLE CHECKPOINTS G1 Checkpoint Enter into S Is environment favorable? G2 Checkpoint Is environment favorable? Has DNA replicated? Enter into MExit M M Checkpoint Are all chromosomes attached to the spindle?
CYCLIN-DEPENDENT KINASES (CDK) & CYCLINS Mitotic cyclin (Cyclin B) Mitotic cdk (cdk 1) Active Mitosis Promoting Factor Degraded mitotic cyclin (Cyclin B) S phase cdk (cdk2) S phase cyclin (Cyclin A) Active cdk2-cyclin A complex Degraded S phase cyclin (Cyclin A)