Presentation on theme: "Physiological Variation in Vascular Reactivity of Breast Tissue over the Menstrual Cycle Demonstrated by Optical Tomography Katz MS1, Hardin RE1, Franco."— Presentation transcript:
1 Physiological Variation in Vascular Reactivity of Breast Tissue over the Menstrual Cycle Demonstrated by Optical TomographyKatz MS1, Hardin RE1, Franco NA1, Smeraldi AD2, Klemer DP3, Schmitz CH3, Pei Y3 Graber HL3, Barbour RL31Department of Surgery, SUNY Downstate Medical Center2Department of Vascular Surgery, Staten Island University Hospital3Department of Pathology, SUNY Downstate Medical CenterBiomedical Optics 2004Miami Beach, FloridaApril 14-17, 2004
2 Optical Tomography Group Technology Data Analysis ApplicationsTime series imagingTime multiplexed DC illuminationFast reconstructionImage enhancement techniquesSignal AnalysisBreast CancerLimbBrainNECQuantitative Functional Imaging
3 Breast Cancer Cancer is the second most common cause of death. (22%) Breast cancer is the most common type of cancer in females. (211,300).The second most common cause of cancer death in females. (40,110)Most common cause of cancer death in African-American females.
5 54% 10 yr survival 84% Clinical Research Follicular Phase Luteal Phase Badwe et al: First study demonstrating correlation between long term survival and phase of menstruation.Follicular Phase Luteal Phase3-12 d. after LMP.0-2, d. after LMP.54% 10 yr survival 84%Badwe RA, Gregory WM, Chaudary MA, Ricahrds MA, Bentley AE, Rubens RD, Fentimen IS, “Timing of Surgery During Menstrual Cycle and Survival of Premenopausal Women with Operable Breast Cancer”, Lancet, 1991,337;1:
7 Materials and Methods 5 Pre-menopausal healthy women were enrolled. Subjects had each breast imaged separately using 25 source x 29 detector array.Each women was measured 3-4 times during the menstrual cycle.Subject were followed for 1-3 months.Subjects were imaged for 1500 consecutive seconds.500 second baseline (2 time points/second).Repeat Valsalva maneuver of 40mm Hg for seconds.200 second rest period.Data analysis consisted of applying various signal processing routines to the image time series.
8 Criteria for Selection of Provocation Effects entire breast.Repeatable.Serves as a useful discriminator.
21 Spatial Map of Onset of Maximal Response Day1Day12Right Breast P1Day19Left Breast P1Right Breast N2Left Breast N2
22 ConclusionsVascular response of breast to the Valsalva maneuver is mainly coherent and repeatable.Response profile to Valsalva maneuver varies over the menstrual cycle.Largest variation in profile is seen with deoxy-hemoglobin whereas largest variation in rate is seen with oxy-hemoglobin.