Presentation on theme: "Real-time Monitoring technology of Mass spectrometry Speaker : Achong."— Presentation transcript:
Real-time Monitoring technology of Mass spectrometry Speaker : Achong
Outline IMS PTR-MS SIFT-MS Application of IMS IMS-TOF IMS-IMS-TOF Application of PTR-MS PIT-MS
Real-time Monitoring Mass spectrometry Environmental science Biochemical and medical diagnosis Workplace safety Security check
EI source Analysis of atmospheric air is especially challenging using electron ionization mass spectrometry, because the gas loading of the ion source by N 2 and O 2 (as well as water vapor) can be excessive. 70 ev
Real-time Monitoring MS Soft chemical ionization Measurement in Real-Time Without pre-concentration system
I. IMS (ion mobility spectrometer) Ion mobility mass spectrometry (Eiceman,1991; Baumbach, 2001) Analytical Chemistry, A390-A397, November 1, 2004
Ion mobility (K) Journal of Bimolecular Technique, Vol.13, Issue 2, June, 2002
Ion mobility mass spectrometry Advantages: Multiform ion source could be applied. Some isomer could be separated. Real-time measurement Disadvantages: Lower mass resolution Lower sensitivity to allow accurate analysis of complex mixtures. Standard is requisite
II. PTR-MS (proton-transfer reaction) Proton-transfer reaction-mass spectrometry (Lagg A, Taucher J, Hansel A, Lindinger W. 1994.) http://info.uibk.ac.at/c/c7/c722/umwelt/html/animation.html
proton-transfer reaction H 3 O + + R → RH + + H 2 0 [RH + ] = [H 3 O + ] o (1 - e -k[R]t ) = [H 3 0 + ] o [R]kt J. Mass Spectrom Ion Processes, 173 (1998) 191-241
PTR mass spectrometry Advantages: Soft ionization and low matrix effect Real-time measurement Low limit of detection (0.5 ppbv for 1-min measurements) Disadvantages: A large number of VOCs could not be identified and quantified.
III. SIFT-MS (selected ion flow tube) http://www.syft.com/ Adams NG, Smith D. 1976. Spanel P,Smith D. 1995.
SIFT mass spectrometry Advantages: application of multiple reagent ions (H 3 O +, NO + and O 2 + ) quantification in real-time discriminate isomers in Real-Time Disadvantages: The kinetic parameters of the reagent ion and the analyte ion must be known. Selected ion flow tube mass spectrometry for no-line trace gas analysis David Smith and Patrik Spanel Reference : Mass Spectrometry Reviews, 2005, 24, 661– 700