4th most common cancer world-wide 2nd leading cause of cancer-related mortality incidence increases with age (rare under the age of 30) highest incidence: Eastern Asia (Japan), Eastern Europe, South America men:women = 2:1
Normal gastric mucosa H.Pylori infection Acute gastritis Chronic active gastritis Atrophic gastritis Intestinal metaplasia Dysplasia Advanced gastric cancer Diagram showing the development of gastric cancer associated with H.pylori infection
Lauren classification: intestinal type diffuse type diffuse carcinoma of linitis plastica type gastric adenocarcinoma of intestinal type
Borrmann classification: polypoid ulcerating ulceroinfiltrative infiltrative gastric adenocarcinoma of polypoid type gastric adenocarcinoma of ulcerative type
advanced disease at the time of presentation symptoms at early stage: fullness in upper abdomen, nausea, anorexia advanced disease symptoms: epigastric pain, nausea, vomiting, dysphagia weight loss anemia (because of bleeding) palpable lymph node – supraclavicular fossa (Virchow’s node)
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