Presentation is loading. Please wait.

Presentation is loading. Please wait.

Acute pseudo- membranous candidosis Acute erythematous candidosis Actinomycosis Herpes simplex Oral Infections Dr Ian Douglas University of Sheffield.

Similar presentations


Presentation on theme: "Acute pseudo- membranous candidosis Acute erythematous candidosis Actinomycosis Herpes simplex Oral Infections Dr Ian Douglas University of Sheffield."— Presentation transcript:

1 Acute pseudo- membranous candidosis Acute erythematous candidosis Actinomycosis Herpes simplex Oral Infections Dr Ian Douglas University of Sheffield

2 Acquisition of oral flora At birth oral cavity is sterile Most species acquired during the first 2 years of life Flora mainly acquired from mother –its all in a kiss!

3 Acquisition of mutans streptococci

4 Plaque -in vivo biofilm

5 Dental caries

6 Stephan Curve Hours pulses pH in plaque

7 Prevalence of some bacteria in caries

8 Mechanical removal of plaque? Toothbrush bristle

9 Topical passive immunisation Anti S.mutans s-IgA cloned into tobacco 3 week application eliminated oral S.mutans

10 Replacement Therapy - Superbugs S Potent bacteriocin producer Stable LDH-deficient mutant Produces ethanol & other acids Imported adh gene bacteriocin

11 Destructive Periodontitis

12 Disease Progression

13 A.odontolyticus V.parvula Association of organisms with disease Pr.intermedia At.actinomycetemcomitans Pr.nigrescens F.nucleatum Pt.micros C.rectus P.gingivalis Ta.forsythus T.denticola S.mitis S.oralis S.sanguis Health Disease

14 Periodontal species detected by 16srRNA Estimate 415 species ~40% were novel phylotypes Detected in at least four diseased subjects, but not in healthy subjects Paster B J Bact 2001; 183;

15 Periapical disease

16 Bacteria associated with endodontic treatment failure

17 Spread of infection from the tooth

18 Examples of oral abscesses

19 Bacterial genera in periapical abscesses * most frequently recovered

20 Antibiotic sensitivity among oral anaerobes Kuriyama et al 2001

21 ß-lacatmase in Prevotella isolates

22 Summary Oral infections are polymicrobial Generally caused by endogenous commensal species There is relatively little microbial specificity for the different types of lesion (except dental caries?) Some oral infections pose treatment problems due to antimicrobial resistance


Download ppt "Acute pseudo- membranous candidosis Acute erythematous candidosis Actinomycosis Herpes simplex Oral Infections Dr Ian Douglas University of Sheffield."

Similar presentations


Ads by Google