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Research Center for Agricultural and Veterinary Sciences.

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1 Research Center for Agricultural and Veterinary Sciences

2 C.I.C.V.y A. Research Center for Agricultural and Veterinary Sciences Instituto Nacional de Tecnología Agropecuaria Research Center for Agricultural and Veterinary Sciences

3 Instituto Nacional de Tecnología Agropecuaria Centro de Investigación en Ciencias Veterinarias y Agronómicas Relationship of CICVyA with Strategic Areas and National Programs OFFICE OF STRATEGIC AREAS Molecular Biology, Bioinformatics and Genetics Advance Genetic Resources, breeding and Biotechnology NATIONAL PROGRAMS Industrial Crops-Oilseeds-Meat-Milk-Cereals-Fruit-Forest-Bee-Vegetables, Flowers and Aromatic Plants, Animal fibers Research Center for Agricultural and Veterinary Sciences

4 Instituto Nacional de Tecnología Agropecuaria Centro de Investigación en Ciencias Veterinarias y Agronómicas Research Center for Agricultural and Veterinary Sciences Next-Generation Vaccines Disease, Herpes Virus (patent), Rotavirus, Bovine Viral Diarrhea, Newcastle (patent), Brucellosis (patent). Expression in Baculovirus systems in canaripoxvirus (patent), in bacteria and plants (patent). Diagnostic reagents for viruses, bacteria and blood parasites. BSE Epidemiology, Disease, and Tuberculosis PPC. Networks and Reference Laboratories: TSE (National Laboratory of Reference for the BSE, INTA, SENASA), RIIDFA, Leptospirosis, Brucellosis and Helminthology. Puitá-INTA (Rice Farming). Support for Improvement in Sunflower, Alfalfa, Wheat, Corn (Mal de Rio IV), Rice, Goats (fiber) and cattle. Integrated pest management and bio-insecticides. Inoculants. Special Services: Boxes biosafety N 2 and 3 (only in Latin America); Detection of GMOs (ISO 17025), DNA Sequencing Service, Laboratory of adventitious virus (ISO 9001), Laboratory of IMYZA Quarantine. Creating EBT (INCUINTA) as a platform for technology transfer. Research Center for Agricultural and Veterinary Sciences Achievements and Contributions of the Research Center

5 Instituto Nacional de Tecnología Agropecuaria Centro de Investigación en Ciencias Veterinarias y Agronómicas Achievements and Contributions of the Research Center 7) Support for Improvement in Sunflower, Alfalfa, Wheat, Corn (Mal de Rio IV), Rice, Goats (fiber) and cattle. 8) Integrated pest management and bio-insecticides. 9) Inoculants. 10) Special Services: Biosafety Boxes N 2 and 3 (only in Latin America). Detection of GMOs (ISO 17025). DNA sequencing service. Adventitious virus laboratory (ISO 9001). Quarantine Laboratory of IMYZA. 11) Establishment of EBT (INCUINTA) as a platform for technology transfer. Research Center for Agricultural and Veterinary Sciences

6 Instituto Nacional de Tecnología Agropecuaria Centro de Investigación en Ciencias Veterinarias y Agronómicas LINKING AND INTERNATIONAL COOPERATION Univ. Fed. de Bello Horizonte (Br) Institute Pasteur (Fr) Univ. Fed. de Pelotas (Br) INRA (Toulouse, Fr) Univ. de Sao Paulo (Br) NEIKER (Vittoria, Esp) EMBRAPA (Br) Inst. Biotecnología (Madrid) INIA Las Brujas (Ur) Unid. Salud Animal (Zaragoza, Esp) SYNTEX Uruguay Univ. de Santander (Esp) Univ. de Costa Rica Univ. de Zaragoza (Esp) CIGB (La Habana, Cu) INIA (Esp) Gobierno de Venezuela (Vz) ALGENEX (Esp) USDA (USA) EMBL (Europa) Univ. of California (USA) Univ. of Hannover (Alem) University of Nebraska (USA) Animal Inst. of Health (Londres, UK) University of Ohio (USA) Medical Research Council (Londres, UK) University of Texas A&M (USA) Univ. of Surrey (UK) JIRCAS (Japón) DARNI (N Ir) USDA (Plumb Island –USA) PRIONICS (Suiza) Research Center for Agricultural and Veterinary Sciences

7 Instituto Nacional de Tecnología Agropecuaria Centro de Investigación en Ciencias Veterinarias y Agronómicas Univ. Buenos Aires (UBA) Univ. de La Plata (UNLP) Univ. Católica de Córdoba Univ. Nac. Tucumán Univ. de Morón (UM) Univ. Del Salvador (USAL) Univ. Belgrano (UB) Univ. Nac. Córdoba (UNC) Univ. Lomas de Zamora Univ. Nac. San Martín Provincias (Chaco-Formosa- Stgo. Sta Fé) Hosp. Nac. Posadas CKC Haras (vários) Asoc. Criadores Shorthorn Asoc.A.Angus Biogenesis-Bagó Prionics Argentina Bioceres S.A. Rizobacter Biosidus Beta S.A. CIALE Estab. Las Marías ENERI (Med. Hum.) Avícola Brandsen Research Center for Agricultural and Veterinary Sciences LINKING AND INTERNATIONAL COOPERATION Research Center for Agricultural and Veterinary Sciences

8 Human Resources C.I.C.V.y A. C.I.C.V.y A Staff Instituto Nacional de Tecnología Agropecuaria Human ResourcesProfesionalsTechnical and support staff INTA Extra INTA10410 TOTAL Research Center for Agricultural and Veterinary Sciences

9 Human Resources - C.I.C.V.y A. Instituto Nacional de Tecnología Agropecuaria STAFF C.I.C.V.y A. Research Center for Agricultural and Veterinary Sciences

10 STAFF C.I.C.V.y A. Instituto Nacional de Tecnología Agropecuaria Research Center for Agricultural and Veterinary Sciences Human Resources - C.I.C.V.y A.

11 Institutos Instituto Nacional de Tecnología Agropecuaria IV Institute of Virology IGEAF Institute of Genetic Ewald A. Favret IP Institute of Pathobiology IMYZA Institute of Microbiology and Agricultural Zoology Centro de Investigación en Ciencias Veterinarias y Agronómicas Institutes Research Center for Agricultural and Veterinary Sciences

12 Instituto Nacional de Tecnología Agropecuaria Centro de Investigación en Ciencias Veterinarias y Agronómicas INSTITUTE OF BIOTECHNOLOGY - IB Research Center for Agricultural and Veterinary Sciences

13 Instituto Nacional de Tecnología Agropecuaria Centro de Investigación en Ciencias Veterinarias y Agronómicas Biotechnology Institute - IB Areas of concern Molecular Biology of Microorganisms genomics Genómica Molecular Breeding and Biotechnology biodiversity biodiversity Bioinformatics Bioenergy Its mission is to develop at INTA modern biotechnology and related areas Research Center for Agricultural and Veterinary Sciences

14 Instituto Nacional de Tecnología Agropecuaria Centro de Investigación en Ciencias Veterinarias y Agronómicas MOLECULAR MICROBIOLOGY APPLIED TO VACCINES AND DIAGNOSTICS New diagnostic strategies, next generation vaccines and molecular studies of veterinary pathogens, their relationship with the environment and the host. FUNCTIONAL GENOMIC GENETIC ENGINEERING Systematic use of platform transcriptomics, preteomics, metabolomics and genetic engineering for solving animal health problems, health and plant stress, food safety and quality. GENOMICS AND BIOINFORMATICS Development of genomic and bioinformatic tools for use in the exploration of genetic diversity, evolution, population structure, mechanisms of pathogenicity, mechanisms of response to biotic stresses, genee mapping and association mapping of important traits for agriculture and forestry Research Center for Agricultural and Veterinary Sciences Biotechnology Institute - IB

15 Instituto Nacional de Tecnología Agropecuaria Centro de Investigación en Ciencias Veterinarias y Agronómicas Research on the genetic basis of traits regulating agricultural use, in order to optimize the processes of plant and animal breeding, as well as understand about genetics methods to monitor the population dynamics of pest and beneficial insects. Centro de Investigación en Ciencias Veterinarias y Agronómicas Institute of Genetics EWALD A. FAVRET - IGEAF Research Center for Agricultural and Veterinary Sciences

16 Instituto Nacional de Tecnología Agropecuaria Centro de Investigación en Ciencias Veterinarias y Agronómicas Institute of Genetics Sources of variability in crop plants Sources of variability in crop plants Genetic transformation Applied to plant breeding Genetic transformation Applied to plant breeding Molecular breeding of forage and salicaceae Molecular breeding of forage and salicaceae Useful molecular tools for improving animal Useful molecular tools for improving animal ANIMAL AREA National players PLANT AREA Research Institute Director Research Institute Director secretary HR Administrative Division and Information Management HR Administrative Division and Information Management Intellectual Property in Agricultural Biotechnology Intellectual Property in Agricultural Biotechnology Maintenance Division, Automotive & Safety health and safety Insect genetics of agricultural importance Insect genetics of agricultural importance Genetic and molecular basis of agronomic importance in plants Genetic and molecular basis of agronomic importance in plants Research Center for Agricultural and Veterinary Sciences

17 Instituto Nacional de Tecnología Agropecuaria Centro de Investigación en Ciencias Veterinarias y Agronómicas ACHIEVEMENTS – Institute of Genetics / EWALD A. FAVRET - IGEAF PLANT AREA Sources of variability in crop plants Genetic transformation applied to plant breeding Molecular breeding of forage and salicaceae Genetic and molecular bases of international agricultural character AREA ANIMAL Genetics of insects of economic importance Useful molecular tools for animal breeding National assessment program players Research Center for Agricultural and Veterinary Sciences

18 Instituto Nacional de Tecnología Agropecuaria Centro de Investigación en Ciencias Veterinarias y Agronómicas Achievements of the Institute of Genetics / EWALD A. FAVRET - IGEAF PLANT AREA Sources of variability in crop plants - Isolation of mutants in higher plants chloroplast gene for infa - Evidence of defective splicing in an intron of the gene ycf3 and its effect on temperature stress tolerance - Using tilling strategy aimed at exploiting chloroplast genes in chloroplasts mutator gene of barley Genetic transformation applied to plant breeding - Optimization of conditions for biolistic transformation of maize and wheat. - Acquisition and development of soybean transformation protocol by agrobacterium. - Progress in wheat and cotton transformation by agrobacterium. - Transformation of maize with sequences of the pathogen to control gene silencing of Mal de Rio Cuarto. - Evaluation of embryogenic capacity lines INTA corn and identification of new materials for use in the process system. Research Center for Agricultural and Veterinary Sciences

19 Instituto Nacional de Tecnología Agropecuaria Centro de Investigación en Ciencias Veterinarias y Agronómicas Achievements of the Institute of Genetics / EWALD A. FAVRET - IGEAF Molecular breeding of forage and silicaceae Development of transgenic alfalfa germplasm Genetic and molecular bases of nternational agricultural character Advances in the study of the genetic basis of resistance to pathogenic organisms in cereals. In recent years there have been advances in: Studies of the genetic basis of durable resistance to leaf rust. Studies on characteristics of the pathogen populations Detailed genetic studies on somes genes in adult plant resistance (components of durable resistance), leading to the cloning of the same. Research Center for Agricultural and Veterinary Sciences

20 Instituto Nacional de Tecnología Agropecuaria Centro de Investigación en Ciencias Veterinarias y Agronómicas PLANT AREA Genetics of insects of economic importance - Detection of problems in the production of natural enemies and potential molecular tools to provide solutions. - Development of molecular markers for anastrepha fraterculus and procurement of materials suitable for molecular ecology studies in fruit flies. - Expertise in cytogenetic - Development of candidate strains of anastrepha fraterculus in sopport of the sterile insect technique. - On tomato moth: cytogenetic characterization of the species. - In beekeeping: genetic characterization of commercial materials and wild bees, and advances in genomics of tolerance to varroa. Progress management / organization: - Consolidation of a strong multidisciplinary team (specialists in molecular genetics, cytogenetics, and eco-physiology of insects) Research Center for Agricultural and Veterinary Sciences Achievements of the Institute of Genetics / EWALD A. FAVRET - IGEAF

21 Instituto Nacional de Tecnología Agropecuaria Centro de Investigación en Ciencias Veterinarias y Agronómicas Useful molecular tools for animal breeding It raised the profile of the utility of molecular tools in animal genetics Progress was made in the organization and human resource development of an interdisciplinary group in genetic and breeding with a quantitative model- molecular in ruminants. National assessment program players Research Center for Agricultural and Veterinary Sciences Achievements of the Institute of Genetics / EWALD A. FAVRET - IGEAF Research Center for Agricultural and Veterinary Sciences

22 Instituto Nacional de Tecnología Agropecuaria Centro de Investigación en Ciencias Veterinarias y Agronómicas Institute of Microbiology and Agricultural Zoology – IMYZA MISSION Conduct research with microorganisms and other organisms of agricultural and agribusiness, designed to obtain essential information or the development of technologies to improve agricultural productivity, without compromising the environment or human health. Research Center for Agricultural and Veterinary Sciences

23 Instituto Nacional de Tecnología Agropecuaria Centro de Investigación en Ciencias Veterinarias y Agronómicas Institute of Microbiology and Agricultural Zoology entomophagous Predators and Parasitoids virus entomopathogenic transformation microbial Waste Entomopathogenic Fungi Bacterial inputs, processes and formulations antagonists of phytopathogenic Phytopathology Diagnosis of Arthropod Pest Plant Growth Promoting Bacteria Research Center for Agricultural and Veterinary Sciences

24 Instituto Nacional de Tecnología Agropecuaria Centro de Investigación en Ciencias Veterinarias y Agronómicas ACHIEVEMENTS - Institute of Microbiology and Agricultural Zoology Creation of 1 Waste Processing Laboratory generated in intensive livestock systems (poultry / pigs / drums), agribusiness (olive) and home. Sectors of work:  Physical Chemistry of aerobic bioconversion processes (composting) and enaerobic (biodigestion)  Respirometry biodegradation  Filtration system complex wastewater  Ecotoxicology of processes and products processed to assess their dangerousness. Waste Processing Plant where teams develop laboratory and pilot scale, some with the possibility of patenting: Reactors anaerobic / aerobic reactors / respirometers static and dynamic / filtering systems with geomembranes. Research Center for Agricultural and Veterinary Sciences

25 Instituto Nacional de Tecnología Agropecuaria Centro de Investigación en Ciencias Veterinarias y Agronómicas Selection and use of biocontrol in IPM strategies in fruit and vegetable crops. Biofactory industrial production of parasitoids of house fly pupae and use within the MIP Development of a liquid formulated with Trichoderma harzianum for controlling phytopathogenic root (Rhizoctonia and Fusarium). Development and transfer of the first national inoculant based liquid Bradyrhizobium japonicum to soybean seeds. Preinoculation system transfer soybean and alfalfa. Development of an inoculant based on Azospirillum brasilense: wheat, barley, sunflower, cotton, horticulture and forestry. Development and transfer of bioinsecticide based B. thuringiensis israelensis for control of Aedes aegypti, vector of dengue. Research Center for Agricultural and Veterinary Sciences ACHIEVEMENTS - Institute of Microbiology and Agricultural Zoology

26 Instituto Nacional de Tecnología Agropecuaria Centro de Investigación en Ciencias Veterinarias y Agronómicas Experimental myco-insecticides: Fruit fly, fly, insect, grasshoppers, boll weevil, Ticks, Diaphorina, Varroa, ants... Granulovirus viral biopesticide pomonella Viral biopesticide pomonella granulovirus Anticarsia gemmatalis nucleopolyhedrovirus Spodoptera frugiperda Nucleopolyhedrovirus Nu Rachiplusia Nucleopolyhedrovirus Research Center for Agricultural and Veterinary Sciences ACHIEVEMENTS - Institute of Microbiology and Agricultural Zoology

27 Instituto Nacional de Tecnología Agropecuaria Centro de Investigación en Ciencias Veterinarias y Agronómicas INSTITUTE OF PATHOBIOLOGY - IP MISSION Conducting original research and applied technology transfer, training to strengthen and improve the efficiency of farming systems and food, from the perspective of animal health. Research Center for Agricultural and Veterinary Sciences

28 Instituto Nacional de Tecnología Agropecuaria Centro de Investigación en Ciencias Veterinarias y Agronómicas Institute of Pathobiology Generate knowledge in animal health Control and prevent diseases of production animals Help control and eradication of diseases that affect: Sfd public Health National and international trade Fasd Articulate capabilities and intra-and extra-activities PEI CHAINS Beef and dairy cattle Poultry Small ruminant Porcine Camelids IP Research Center for Agricultural and Veterinary Sciences

29 Instituto Nacional de Tecnología Agropecuaria bacterial zoonoses - Secretary - Administrative Division and Communication Division - Secretary - Administrative Division and Communication Division Pathology Diagnostic research Epidemiology Clinical biochemistry and Toxicology Research Insitute Director Parasitic Zoonoses Microbiology - Quality and Biosafety Division - Health and Safety -Field and Experimental Division - Maintnance - Quality and Biosafety Division - Health and Safety -Field and Experimental Division - Maintnance Technicians 37 Professionals 37 Residents 11 Technicians 37 Professionals 37 Residents 11 Parasitic diseases Microbiology and Physiology Pathology and Epidemiology Parasitology and Parasitic Diseases Physiology Research Center for Agricultural and Veterinary Sciences INSTITUTE OF PATHOBIOLOGY - IP Research Center for Agricultural and Veterinary Sciences

30 Instituto Nacional de Tecnología Agropecuaria Centro de Investigación en Ciencias Veterinarias y Agronómicas Activities - Institute of Pathobiology Contribute to the expansion Sustainable Production Through Improved No Livestock Handling, Health Care and feeding PR PPR PI  TUSGO, Livestock Height  Diseases affecting public health (zoonoses)  Diseases that affect international trade (FA; BSE)  Diseases affecting animal production (parasitic, metabolic, toxic) Interactions  AE Molecular biology  AE Genetic resources AE Animal Health Emerging activities  Veterinary public health  Resistance to antimicrobial and antiparasitic  Animal welfare Detect and exploit the new problems and thus to design new strategies  Small family farming  Wild Animals  Climate change Research Center for Agricultural and Veterinary Sciences

31 Instituto Nacional de Tecnología Agropecuaria Centro de Investigación en Ciencias Veterinarias y Agronómicas ARTICULATIONS Cca del Salado Cnia. Benitez Tucumán San Juan Stgo. del Estero San Luis IPAF Rafaela Marcos Juárez Anguil BarilocheBalcarce Salta Mercedes Concepción CNIA  CICVyA  CIA  CIRN Institute of Pathobiology Research Center for Agricultural and Veterinary Sciences

32 Instituto Nacional de Tecnología Agropecuaria Centro de Investigación en Ciencias Veterinarias y Agronómicas Instituto of Pathobiology BASIC RESEARCH TECHNOLOGY TRANSFER PRESENCE IN TERRITORY Research Center for Agricultural and Veterinary Sciences

33 Instituto Nacional de Tecnología Agropecuaria Centro de Investigación en Ciencias Veterinarias y Agronómicas Research and development of technologies and services related to viral diseases affecting animal species of economic interest, their interaction with the host and the immune response induced in order to facilitate the detection, characterization and control by developing techniques and reagents; study and management of immune response and the development and evaluation of processes and products. Centro de Investigación en Ciencias Veterinarias y Agronómicas INSTITUTE OF VIROLOGY - IV Research Center for Agricultural and Veterinary Sciences

34 Instituto Nacional de Tecnología Agropecuaria Centro de Investigación en Ciencias Veterinarias y Agronómicas Institute of Virology STRATEGIC AREAS Animal health Molecular Biology, Bioinformatics and Genetics Advance Genetic Resources, Breeding and Biotechnology NATIONAL PROGRAMS Value chains Meat-Milk Research Center for Agricultural and Veterinary Sciences

35 Instituto Nacional de Tecnología Agropecuaria Centro de Investigación en Ciencias Veterinarias y Agronómicas ACHIEVEMENTS – Institute of Virology First isolates of influenza virus in birds and pigs in the RA First isolation of rotavirus in camels subamericanos First isolation of WNV, and equine viral arteritis in the RA Vaccine HVB1 gE-E2 and DVB-stage transfer Use of an attenuated strain for the control of BLV Phase III Animal models applied to the control of viral vaccines SENASA HHV protective capacity diarrhea caused by rotavirus Strategic services specialized in quality standard ISO INCUINTA National EIA diagnostic kit using a recombinant protein VHH production platform (Nanoanticuerpos) IgY anti-diarrheal product using EBT ACHIEVEMENTS Research Center for Agricultural and Veterinary Sciences

36 Contacts Research Center for Agricultural and Veterinary Sciences Research Center in Natural Resources Research Center in Agroindustry INTA Instituto Nacional de Tecnología Agropecuaria Research Center for Agricultural and Veterinary Sciences

37 Instituto Nacional de Tecnología Agropecuaria Thank you!


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