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PB1: Differences in Mammalian Viruses Compared to Avian 0 0 1 1 1 1 1 1 1 2 2 2 2 2 2 3 3 3 3 3 3 4 4 4 4 4 5 5 5 5 6 6 6 6 6 6 7 5 5 0 1 2 7 7 8 9 0 0.

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Presentation on theme: "PB1: Differences in Mammalian Viruses Compared to Avian 0 0 1 1 1 1 1 1 1 2 2 2 2 2 2 3 3 3 3 3 3 4 4 4 4 4 5 5 5 5 6 6 6 6 6 6 7 5 5 0 1 2 7 7 8 9 0 0."— Presentation transcript:

1 PB1: Differences in Mammalian Viruses Compared to Avian AvianK K L V K D M E M V K L S S L I R V S N E A R D V R L E R P Q V V S I K A R S D L – I M N Early H1- R N S D I N - - T R I - - K G I R I M N h r M M R T Later H1R R I – V I D L – I M N – R T I K M I S V Early H I S - V K i v Later H I N S - V K S T - - R Early H R V K - - S m t Later H I V K I R S - - K - - K – D Q – R S r g Equine N R S D - K K Cl.Swine S D L - I D N R R v g k i N g k n v l H k T v T New Swine S S V R r I i V G K I R – K K i D Q R S

2 PB1-F2 Alignment Optimal MTS Predicted  -helical regions Avian Eurasian consensusMEQEQDTPWTQSTEHINIQKRGNGQQTQRLEHPNSTRLMDHYLRIMSRVGMHKQIVYWKQWLSLKNPTQGSLKTRVLKRWKLFSKQEWIN. Avian No. Am. consensus--R L-Q----C--T----D----T-SL S---E N----T-. K 1957 H2N2 consensus S----RK--R--L-Q T-NQ-D----TAS E N----T-. Late H2N2 viruses-G T------s----RK--R--L-Q T-NQ-D----TAS H--E---I N----T-. - G T H3N2 consensus K-S----RK--RP-L-Q Q-D----TVS N--G-TD. Late H3N2 viruses-----G T------S-R-Q-K-G-—S-RQ Q-D----T-S-RP-P R-HA--Q---S---G-TD - F L PB1-F2-G IL--G--ST---ED----P----H CQKT-NQ-V-P RS--PV R----H--TS. WSN/33-G IL--G--ST--GED----PK---R------G-CQKT-NQ-V-P P--R--ILV--RP------R----H--T. PR/8/34/MS-G IL--G--ST---ED----PK---R------G-CQKT-NQ-V-P R--ILVF R----H-. FM/1/47---G-----IL--G--ST--GEG----PK---H CQKT-NQ-V-P R--ILVF------RQ-R----H--T. Beijing/56-G IL--G--ST--GED----PK---HS-----G-YQKT-NQ-V-P Fiji/83-G I---G--ST--GED----PK---R------G-YQKT-NQ-V-P Swine/Iowa/1976/31-G----I--IL-----ST---E-----LK---HN. Swine/Tennessee/26/77-G IL. Swine/Ontario/2/81-G IL. Swine/Colorado/1/77-E T K-S GR----Q QAD--NRT-S F----A-----S-N--G-. Swine/Finistere/2899/82-E-G-----T ES SL P-T-NQAD------S-R Y---H--R—R Swine/Hong Kong/126/82-E T-----T-----ES SL P-T-NQA S-R—H N----T. Swine/Cotes d'Armor/84-E T T--GE SL P-T-NQAD------S-R---T Y------R—R Equine/London/73(H7N7) IL----T-T L----H--IQS-GRC-KT-NQADTP P--S-IP RW--R---T Equine/Tenn/86(H3N8) IL----T-T L----H--IQS--RF-KT-NQA-TP IPE---I------RW--R---T


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