3 A New Dimension in Feminine Hygiene Line features:4 types of specially formulated external vaginal cleansing productsSoothing application gel gently soothes irritated external vaginal areasA lubricating gel for vaginal drynessIntimate wipes
4 Why use intimate wash? Scientific explanation: Many women suffer from vaginal discharge, often associated with a disturbance of the normal vaginal environment, including a change in the vagina's normal level of acidityThe normal pH of the vagina is acidic, fluctuating between 3.8 – 4.5, discouraging infection from occurringThe acidic environment is created by the presence of Lactic acid, which is the byproduct of the glycogen metabolism by normal - existing bacteria
5 Mechanism of Vaginal Defense Lactic Acid BacteriaNatural FloraIdeal pH environmentfor the growth of thevaginal floraestrogenGlycogenLactic AcidLactobacilli exist in 80% of normal vaginal flora and act antagonistically against other microorganismspHAntibacterial action
6 Optimal pH Growth of some Common organisms Acidic pH conditions are unfavorable to digestive bacteria:Escherichia coli, bactéroides sp.
7 Vaginal imbalanceAlteration in pH disturbs the fragile balance of the vagina, causes reduction in the number of lactic acid bacteria and sets up an environment conductive to inflammation called Vaginitis.
8 Symptoms of vaginal imbalance Vaginal tendernessItchingUnpleasant vaginal dischargesRednessDrynessPain during intercourse
9 Why choose Femina? 4 Good reasons: The Company behind the product Line performanceLine advantagesProducts quality
10 Why choose Femina?When you marry someone , you better know it’s family…
11 Why choose Femina? Pharmaceutical Company Femina line is manufactured by a leading Israeli pharmaceutical company operating since 1921.Focus on the Gynecology Field-CTS Develops, manufacture and market pharmaceutical products ,among them isa wide range of pharmaceutical gynecological products.Femina line was developed 14 years ago as a completion to our gynecological pharmaceutical and medical device products and was initially introduced only to Gynecologists.International experienceCTS enjoy business associations with some of the major world companies, amongst them: Astellas, UCB, Nycomed, Besines, Sanofi-Aventis, Mitsubishi Pharma, OPI and others.
12 Why choose Femina? Line preformance No 1 brand in IsraelFemina is the leading line in Israel for intimate wash, before Liginia, care-freeThe most recommended brand by Gynecologists in Israel48% of the gynecologists in Israel, that recommends on intimate wash, recommends on Femina.Femina market share in the intimate wash Category – 42% !!.International Market penetrationSince Last year (2008) : 7 distribution contracts for international markets.(USA/Canada, Australia, Singapore, Taiwan, Romania , S. Africa, Cyprus)
13 About half of the gynecologists recommending Femina (17% of all ) Recommended Intimate wash by Gynecologists In IsraelN=35About half of the gynecologists recommending Femina (17% of all )
14 Why choose Femina? Line Advantages Comprehensive solution for women intimate wash needs :Contains 7 preparations covering women needs in all aspects:All agesDifferent time’s in woman life.( pregnancy, period , menopausal)Daily use and special use ( usual day routine , traveling , intercourse, irritation.. etcFriendly Formulation:Free of ParabensFree of SLS & SLES
15 Why choose Femina? Line Advantages 3.5 PH level formulationHelp maintain acidic pH; contains lactic acid combined with itsspecial formulation developed for specific women’s needsencourage the natural vaginal acidity & promote the body's natural microbialbalanceCalm the vaginal discharge symptoms;Help women to avoid reappearance of vaginal discharge“Live” Brand :Due to the fact it is a strategic field of CTS , the line is covered by continues R&D support and marketing support by its brand managersFuture developments under evaluation: ECOCERT formulations , Teenage version, intimate deodorant, calming cream for the intimate area.
16 Femina liquid soaps contains Lactic Acid Restores the vaginal pH to normal values (4,5)Help the growth of natural floraDecrease the number of pathological microorganismLong lasting antibacterial action, as it maintains the natural flora and normal pH
17 The leading intimate wash brand in Israel FeminaFeminine Intimate HygieneThe leading intimate wash brand in Israel
19 FeminaClassicScientifically formulated to promote the body's natural vaginal balanceContains Lactic Acid to promote the natural vaginal acidic pH balance3.5 PH level formulationContains Tree Tea Oil, one of natures essential oils well known for its natural mild antiseptic properties which helps promote the body's natural microbial balanceCleansing and refreshingSuitable for women of all agesFor daily useFree of ParabensFree of SLS & SLESHypo-Allergenic
20 What is Tea Tree Oil? Botanical Name: Melaleuca Alternifolia Tea tree has a long history of traditional use:Australian aboriginals used tea tree leaves for healing skin cuts, burns, and infections by crushing the leaves and applying them to the affected areaTea tree oil contains constituents called terpenoids, which have been found to have antiseptic and antifungal activity.
21 Use of tea-tree oil in Trichomonal Vaginitis In June 1962 an American report was published in obstetrics and Gynecology on the use of tea-tree oil in trichomonal vaginitis.The study comprised 130 women, including ninety-six cases of trichomonal vaginitis, and also several cases of thrush and cervicitis. As controls the author treated fifty other cases with standard antitrichomonal suppositories.E. Pena, 'Melaleuca alternifolia Oil: its use for Trichomonal Vaginitis and Other Vaginal Infections', Obstetrics and Gynecology, vol. 19 (6) pp
22 Tea-tree oil & Candida Albicans For this study tea-tree oil was made into pessaries for insertion into the vagina once every night.After thirty days the twenty-seven patients were examined, and twenty-three showed a complete cure with no further discharge or burning. The other four showed a moderate improvement.P. Belaiche, 'Germicidal Properties of the Essential Oil of Melaleuca alternifolia Related to Urinary Infections and Chronic Ideopathic Colibaccillus', ibid, pp. 9-11
23 Antimicrobial Activity This review summarizes recent developments of the antimicrobial and anti-inflammatory activities of the oil and its components, as well as clinical efficacy.Carson CF. Clin Microbiol Rev Jan;19(1):50-62
24 Antifungal activityStudies conclusions: The majority of the organisms were sensitive to the essential oil, with TTO (Tea Tree Oil) and terpinen-4-olo being the most active oils showing antifungal activity at minimum inhibitory concentration values lower than other drugs.SIGNIFICANCE AND IMPACT OF THE STUDY: This study provides a sample large enough to determine the antifungal properties of TTO and terpinen-4-olo and suggests further studies for a possible therapeutic use.Oliva B. Lett Appl Microbiol. 2003;37(2):185-7
25 Femina Therapy Liquid Soap Enriched with Sea Buckthorn for intimate external vaginal cleansing
26 FeminaTherapyEnriched with Sea Buckthorn oil, which is well known for its soothing and healing components to prevent over drying and irritationFor women of all ages3.5 PH level formulationFor daily useFree of ParabensFree of SLS & SLES
27 Sea BuckthornSea buckthorn contains different kinds of nutrients and bioactive substances such as vitamins, carotenoids, flavonoids, polyunsaturated fatty acids, free amino acidsThe clinical trials and scientific studies during the 20th century confirmed the medicinal values of sea buckthorn.
31 Femina Plus Liquid Soap Enhanced with moisturizing for intimate external vaginal cleansing
32 FeminaPlusEnriched with a Vitamin B3 moisturizer to help prevent vaginal dryness and irritationSpecially recommended for women suffering from vaginal dryness and for menopausal women3.5 PH level formulationFor daily useFree of ParabensFree of SLS & SLESHypo-Allergenic
33 Moisturizing & Anti Inflammatory effect of vitamin B3 Other names include: 3-pyridinecarboxamide, Nicamid, Nicotinamide, Nicosedine, Nicotinic Acid Amide, Nicotylamidum, and Vitamin PPNiacinamide has been used in skin care products, including moisturizers, anti-aging productsNiacinamide has demonstrated anti-inflammatory actions which may be of benefit in patients with inflammatory skin conditions.
34 Supportive literature Measuring the effects of topical moisturizers on changes in stratum corneum thickness, water gradients and hydration in vivoCrowther JM. Br J Dermatol Sep;159(3): Epub 2008 Jul 4Nicotinamide - biologic actions of an emerging cosmetic ingredientOtte N. Int J Cosmet Sci Oct;27(5):255-61Nicotinic acid/niacinamide and the skinGehring W. J Cosmet Dermatol Apr;3(2):88-93.
36 FeminaSensitiveEnriched with Aloe Vera – well known for its soothing, moisturizing and cooling properties for relieving skin discomfortRecommended for use during pregnancy, after childbirth, during menstruation (vaginal sensitivity), and after swimming in pool/sea etc.3.5 PH level formulationFor daily useFree of ParabensFree of SLS & SLESHypo-AllergenicSensitivity test approved
37 Antimicrobial, Antifungal & Healing activities of Aloe A novel polyherbal microbicide with inhibitory effect on bacterial, fungal and viral genital pathogens“…It has pronounced inhibitory action against Candida glabrata, Candida albicans and Candida tropicalis isolated from women with vulvovaginal candidiasis, including three isolates resistant to azole drugs and amphotericin B…”Int J Antimicrob Agents Aug;32(2): Epub 2008 Jun 20
38 Antimicrobial, Antifungal & Healing activities of Aloe Aloe vera: a systematic review of its clinical ffectiveness“…Topical application of aloe vera is not an effective preventative for radiation-induced injuries. It might be effective for genital herpes and psoriasis... ”Br J Gen Pract Oct;49(447):823-8
39 Antimicrobial, Antifungal & Healing activities of Aloe Wound healing. Oral and topical activity of Aloe vera“…The influence of Aloe vera, orally and topically, on wound healing was studied…These data suggest that A. vera is effective by both oral and topical routes of administration…”J Am Podiatr Med Assoc Nov;79(11):559-62
40 Soothing Application Gel FeminaSoothing Application GelFor External Vaginal Hygiene
41 Soothing Application Gel FeminaSoothing Application GelSpecially formulated and enriched with a high concentration of natural soothing plant extracts such as Aloe Barbadensis Leaf Extract, Allantoin, Echinacea Angustifolia, Calendula Officinalis Extract, Comfrey Extract, Propolis Extract, Witch Hazel Extract and Matricaria Extract (Chamomile)Relieves itching, burning, soreness, unpleasant odor and other irritations of the external vaginal areaThe use of this preparation is not a replacement for medical treatment
42 Natural healing extracts - Comfrey What is Comfrey?Comfrey (Symphytum officinale L.) is a perennial herb of the family BoraginaceaeBeneficial effects of Comfrey as an active ingredient:The herb contains allantoin, a cell proliferant that speeds up the natural replacement of body cells.Comfrey is used to treat severe burns, acne and other skin conditions.Phytomedicine Sep;11(6):470-7Fortschr Med Orig. 2002;120(1):1-9Public Health Nutrition., (4A): pComfrey Central - A Clearinghouse for Symphytum Information
43 Natural healing extracts - Allantoin What is Allantoin?Major metabolic intermediate.Beneficial effects for Allantoina moisturizing and keratolytic effect, increasing the water content of the extracellular matrix and enhancing the desquamation of upper layers of dead skin cellsIncreasing the smoothness of the skinPromotion of cell proliferation and wound healingSoothing, anti-irritant, and skin protectant effect by forming complexes with irritant and sensitizing agentsDermatol Surg Jul;31(7 Pt 2):873-80; discussion 880. Review.Dermatology. 1999;199(4):319-22J Invest Dermatol Oct;91(4):363-8Sex Transm Dis Mar;24(3):156-60Med Ann Dist Columbia Jul;37(7):358-9 passimCan Med Assoc J Dec 14;99(23):1131-3
44 Natural healing extracts – Coneflower (Echinacea Angustifolia) What is Coneflower (Echinacea Angustifolia)?Echinacea is a genus of nine species of herbaceous plants in the family Asteraceae commonly called Coneflower.Beneficial effects for Coneflower as an active ingredient:Echinacea is found as immuno-stimulator, stimulating the body's non-specific immune system and warding off infectionsEfficient to treat Vaginal yeast infectionsLancet Infect Dis Jul;7(7):473-80Drug Saf. 2005;28(5):Ethnopharmacol Feb;79(2):Mayo Clinic. "Echinacea (E. angustifolia DC, E. pallida, E. purpurea)".
45 Natural healing extracts - Propolis What is Propolis?Propolis is a resinous mixture that honey bees collect from tree buds, sap flows, or other botanical sources.Beneficial effects for Propolis as an active ingredient:Propolis show powerful local antibiotic and antifungal propertiesEffective as alternative treatment for chronic vaginal infection (Vaginitis)Int J Gynaecol Obstet May;89(2):127-32Rev Cubana Enferm Jan-Jun;11(1):51-6Biol Pharm Bull Oct;28(10):
46 Natural healing extracts - Witch-hazel (Hamamelis) What is Witch Hazel?The main constituents of the extract include gallic acid, catechins, proanthocyanins, flavonoids, essential oil, choline, saponins, and bitters.Witch hazel hydrosol is used in skin careBeneficial effects for Witch hazel as an active ingredient:Witch hazel leaf has been used for minor injuries of the skin, inflammation of the skin and mucous membranesCooner, S. New England Natives: A Celebrations of Trees and People. Cambridge, Mass: Harvard University Press, 1994.Planta Medica, 62(1996) (3):The Wiley Witch Hazel. The Herb Companion.( January 1989).European Journal of Clinical Pharmacology 48(1995)(6):Journal of Dermatological Science. 10(1995)(1):25.34.
47 Natural healing extracts - Matricaria (Chamomile) What is Matricaria?The flowers of chamomile provide 1-2% volatile oils containing alpha-bisabolol, alpha-bisabolol oxides A & B, and matricin (usually converted to chamazulene). Other active constituents include the bioflavonoids apigenin, luteolin, and quercetin.Beneficial effects for Matricaria as an active ingredient:Chamomile has anti-inflammatory, antioxidant and antimicrobial activitiesWound healingPhytother Res Feb;23(2):274-8Phytother Res July 20 (7): 519–30Nat Prod Res Mar 20;22(5):422-7
48 Natural healing extracts - Calendula Officinalis What is Calendula Officinalis?It was used in ancient Greek, Roman, Arabic and Indian cultures as a medicinal herbThe petals and pollen contain triterpenoid esters (an anti-inflammatory) and the carotenoids flavoxanthin and auroxanthin (antioxidants, and the source of the yellow-orange coloration).The leaves and stems contain other carotenoids, mostly lutein (80%) and zeaxanthin (5%), and beta-carotene. Plant extracts are also widely used by cosmetics, presumably due to presence of compounds such as saponins, resins and essential oilsBeneficial effects for Calendula as an active ingredient:Calendula has anti-inflammatory, antioxidant and antimicrobial activitiesContact Dermatitis Nov;45(5):269-72J Clin Pediatr Dent Spring;24(3):237-43Skin Therapy Lett. 2000;5(4):3-5Oftalmologia. 1999;46(1):55-7. Romanian.
50 Femina Lubricating Gel For increased lubrication and comfort during intercourseSuitable for daily use in cases of vaginal dryness and eases insertion of tampons or a rectal thermometerSafe for use with condomsAdjusted to skin's natural acidity, washes off easily, non-staining, pleasant to the touch, non-greasy and easy to use
52 FeminaTo GoThe perfect solution for intimate hygiene, wherever you are and whatever your activityHandy wipes, easy to carry and convenient to use when travelling outside the home and on tripsHelps to prevent unpleasant odorsContains Lactic Acid to enhance the vagina's natural protection, and allantoin to soothe the skinFor daily use including during the menstrual periodAlcohol free!
53 Natural healing extracts - Allantoin What is Allantoin?Major metabolic intermediate.Beneficial effects for Allantoina moisturizing and keratolytic effect, increasing the water content of the extracellular matrix and enhancing the desquamation of upper layers of dead skin cellsIncreasing the smoothness of the skinPromotion of cell proliferation and wound healingSoothing, anti-irritant, and skin protectant effect by forming complexes with irritant and sensitizing agentsDermatol Surg Jul;31(7 Pt 2):873-80; discussion 880. Review.Dermatology. 1999;199(4):319-22J Invest Dermatol Oct;91(4):363-8Sex Transm Dis Mar;24(3):156-60Med Ann Dist Columbia Jul;37(7):358-9 passimCan Med Assoc J Dec 14;99(23):1131-3
54 39 Rothschild St. Kefar Saba, 44449 – Israel Contacts:39 Rothschild St. Kefar Saba, – IsraelTel: (972) Fax: (972)