4 TreatmentCurrently there is only treatment for WET macular degeneration.LucentisEylea
5 Early AMD Vision is good Drusen present Diagnosis usually picked up on routine visit to the Optometrist.No signs of any late AMD progression
6 2RT nanosecond laser- Ellex Speckled effect LaserKilling sick RPE cellsHealthy cells will divide, and bridge over the gap the laser has leftNew cells will function to clear away the debris in Bruch's Membrane.Gentle laserDoesn’t leave burns(like current lasers do)Painless.
7 2RT Pilot studyThe world first Pilot study of the Ellex nanosecond laser in the treatment of Early AMD ran for 3 years.50 ParticipantsAll had 1 eye treated with the2RT nanosecond laser
8 2RT Pilot study results Reduction in Drusen Improved Macular Function We are seeing these results in not only the treated eye but in some cases the fellow non-treated eye
10 Bilateral Effect Right Eye Baseline RE 3 months post laser to LE So drusen goes away in treated and some times in other eye
11 Bilateral EffectBefore Treatment to LE months post laser to LE
12 Bilateral Effect Before laser to RE 12 months after Laser to RE . A) Macular flicker sensitivities and drusen changes in both eyes of a patient aged 55, before (top) and 6mths after (bottom) laser treatment to right eye. Graphical representations of flicker visual field deviation and macular photo are shown. Note that the focal defect on the non-treated eye has resolved completely and the treated eye has improved, along with some drusen reduction (black arrows
13 LEAD STUDYWith positive results from the Pilot study, we received an NHMRC grant to conduct the worlds first multi centred randomised control trial of nanosecond laser in the treatment of early AMD. (LEAD Trial)
14 LEAD StudyAim: To provide an Early intervention, which may slow or partially reverse the progression of the disease, before any late changes develop.
15 LEAD Update Recruitment will finish at the end of 2014. Aiming to have 150 participants at the RVEEH site.Overall recruitment aim is 350 participants.Multiple sites recruiting.Melbourne (2 sites)SydneyAdelaidePerthNorthern Ireland
16 LEAD Inclusion criteria Bilateral high-risk early AMDBest corrected VA 6/12 or better in each eye50-95 years of ageMAIA perimetry result of <25 dB in one eye in the same area on 2 tests
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