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Laser Intervention in Early Age Related Macular Degeneration Emily Caruso – LEAD trial Coordinator.

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Presentation on theme: "Laser Intervention in Early Age Related Macular Degeneration Emily Caruso – LEAD trial Coordinator."— Presentation transcript:

1 Laser Intervention in Early Age Related Macular Degeneration Emily Caruso – LEAD trial Coordinator

2 AMD Macular degeneration is one of the leading causes of blindness in Australia.

3 Stages of AMD Early AMD Wet AMD Dry AMD

4 Currently there is only treatment for WET macular degeneration. Lucentis Eylea Treatment

5 Early AMD Vision is good Drusen present Diagnosis usually picked up on routine visit to the Optometrist. No signs of any late AMD progression

6 2RT nanosecond laser- Ellex Speckled effect Laser – Killing sick RPE cells Healthy cells will divide, and bridge over the gap the laser has left New cells will function to clear away the debris in Bruch's Membrane. Gentle laser Doesn’t leave burns (like current lasers do) Painless.

7 2RT Pilot study The world first Pilot study of the Ellex nanosecond laser in the treatment of Early AMD ran for 3 years. 50 Participants All had 1 eye treated with the 2RT nanosecond laser

8 2RT Pilot study results Reduction in Drusen Improved Macular Function – We are seeing these results in not only the treated eye but in some cases the fellow non-treated eye

9 Drusen Regression Baseline 9 months

10 Bilateral Effect Right Eye Baseline RE 3 months post laser to LE Right Eye Baseline RE 3 months post laser to LE

11 Bilateral Effect Before Treatment to LE 3 months post laser to LE

12 Bilateral Effect Before laser to RE 12 months after Laser to RE

13 LEAD STUDY With positive results from the Pilot study, we received an NHMRC grant to conduct the worlds first multi centred randomised control trial of nanosecond laser in the treatment of early AMD. (LEAD Trial)

14 LEAD Study Aim: To provide an Early intervention, which may slow or partially reverse the progression of the disease, before any late changes develop.

15 LEAD Update Recruitment will finish at the end of Aiming to have 150 participants at the RVEEH site. Overall recruitment aim is 350 participants. Multiple sites recruiting. – Melbourne (2 sites) – Sydney – Adelaide – Perth – Northern Ireland

16 LEAD Inclusion criteria Bilateral high-risk early AMD Best corrected VA 6/12 or better in each eye years of age MAIA perimetry result of <25 dB in one eye in the same area on 2 tests

17 THANK YOU! Any Questions


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