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One Tiny Mold, One Big Problem: Aspergillosis By: Melanie Yodock.

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Presentation on theme: "One Tiny Mold, One Big Problem: Aspergillosis By: Melanie Yodock."— Presentation transcript:

1 One Tiny Mold, One Big Problem: Aspergillosis By: Melanie Yodock

2 Outline O History of Aspergillosis O Aspergillus species information O People at Risk O Clinical Types O Detection/Diagnosis O Treatment

3 History O First noted in 1815 O Secondary infection O Associated with certain occupations

4 Aspergillus sp. O Taxonomy O Named after aspergillum O species O species O species O 5 common species O Many rarer species O Morphology O Saprophytes O Small, fluffy, white colonies O Pathogenic species can be different colors

5 People at Risk O AIDS patients O Neutropenia O Chronic Granulomatous Disease O Solid Organ Transplant Recipients O Hematopoietic Stem Cell Transplant Recipients (HSCT)

6 Clinical Cases O Pulmonary Aspergillosis O Aspergillomas O Granulomatous aspergillosis

7 Clinical Cases Cont. O Otomycosis O Aspergillus Sinusitis

8 Clinical Cases Cont. O Tracheobronchitis O Cutaneous Aspergillosis

9 Clinical Cases Cont. O Cerebral Aspergillosis

10 Detection/Diagnosis O BAL cultures O (1→3)- β --glucan assay

11 Detection/Diagnosis O CT scans O Laboratory Markers and PCR

12 Treatment O Amphotericin B O Voriconazole O Itraconazole O Caspofungin O Posaconazole

13 Summary O Aspergillosis has been around for hundreds of years O Secondary infection in immunocompromised patients O Many clinical types of aspergillosis O New detection techniques are allowing for earlier diagnosis O Many treatment options but an ongoing battle with fungal evolution and resistance

14 References O Denning D.W Invasive Aspergillosis. Clinical Infectious Diseases. 26: O Denning D.W., Ribaud P., Milpied N., Caillot D., Herbrecht R., Thiel E., Haas A., Ruhnke M., Lode H Efficacy and Safety of Voriconazole in the Treatment of Acute Invasive Aspergillosis. Clinical Infectious Diseases. 34: O Di Somma A., Bailey T., Silvanose C., Garcia-Martinez C The Use of Voriconazole for the Treatment of Aspergillosis in Falcons (Falco Species). Journal of Avian Medicine and Surgery. 21(4): O Emmons C.W., Binford C.H., Utz J.P Medical Mycology, Second Edition. Philadelphia: Lea and Febiger, pp O Grant S.M., Clissold S.P Itraconazole. Drugs. 37(3): O Kendrick B The Fifth Kingdom: Third Edition. Newburyport MA: Focus Publising, pp O Marr K.A., Carter R.A., Crippa F., Wald A., Corey L., Epidemiology and Outcome of Mould Infections in Hematopoietic Stem Cell Transplant Recipients. Clinical Infectious Diseases. 34: O Ostrosky-Zeichner L., Alexander B.D., Kett D.H., Vazquez J., Pappas P.G., Saeki F., Ketchum P.A., Wingard J., Schiff R., Tamura H., Finkelman M.A., Rex J.H Multicenter Clinical Evaluation of the (1→3)- β -- Glucan Assay as an Aid to Diagnosis of Fungal Infections in Humans. Clinical Infectious Diseases. 41: O Segal B.H., Walsh T.J Current Approaches to Diagnosis and Treatment of Invasive Aspergillosis. American Journal of Respiratory and Critical Care Medicine. 173: O Walsh T.J. Dixon D.M Nosocomial Aspergillosis: Environmental Microbiology, Hospital Epidemiology, Diagnosis and Treatment. European Journal of Epidemiology. 5(2): O Wilson J.W., Plunkett O.A The Fungous Diseases of Man. Berkeley: University of California Press, pp

15 Photo References O k0RUM&tbnid=hEAB4mdgp6pEaM:&ved=0CAQQjB0&url=http%3A%2F%2Fwww.pennmedicine.org%2Fenc yclopedia%2Fem_PrintArticle.aspx%3Fgcid%3D000127&ei=dvKEUoOSEI3gsATDpIG4DA&bvm=bv ,d.cWc&psig=AFQjCNEjihPGApdnCB7XdIgjJI2N38YJwg&ust= O WRRrCJM:&ved=0CAcQjB0wAA&url=http%3A%2F%2Fpathhsw5m54.ucsf.edu%2Fcase16%2Faspergilloma. html&ei=3fKEUqn5I5LgsATloYGIBw&psig=AFQjCNEd5dPAn8wO60pgpdCFRozND9PrlA&ust= O URJjdzBM:&ved=0CAcQjB0wAA&url=http%3A%2F%2Focw.tufts.edu%2FContent%2F72%2Fimagegallery%2 F %2F %2F &ei=0POEUs_sFI3IsATW04KAAg&psig=AFQjCNFggl1ekrlD- p3Pz7N2QCLh4ve66Q&ust= O wjqOM&tbnid=LWTLbMnqPUoTqM:&ved=0CAcQjB0wADgO&url=http%3A%2F%2Fen.wikipedia.org%2Fwiki %2FOtitis_externa&ei=BvWEUpfdDMHhsATIyYGwBg&psig=AFQjCNEuCrbmMyANH- 3mXySgDeW54n87GQ&ust= O cxHDPrHM:&ved=0CAcQjB0wADhk&url=http%3A%2F%2Fent4students.blogspot.com%2F2013%2F05%2F ent-pictures-ear.html&ei=gvWEUsnPJIXLsQSlrYDgDg&psig=AFQjCNEwGrjp9PL5rZPCG_CAD- YYIuIchg&ust=

16 Photo References O cDFBM&tbnid=2KOhucEVndYk2M:&ved=0CAcQjB0wAA&url=http%3A%2F%2Fcare.american- rhinologic.org%2Ffungal_sinusitis&ei=LPaEUtCNG5LdsASsgIL4BA&psig=AFQjCNEaIg8Tc7oCVLFfNtFT7OpIQ fZltg&ust= O WJL7WM:&ved=0CAcQjB0wAA&url=http%3A%2F%2Fwww.aspergillus.org.uk%2Fsecure%2Ftreatment%2Ftr acheo.php&ei=E_eEUvunI47EsATN7IHYDQ&psig=AFQjCNH5TDXWqUrXCbDg0Otwo3V2aAcbEA&ust= O 9EnpItc0M&tbnid=q9UgMnvK2pgrtM:&ved=0CAcQjB0wAA&url=http%3A%2F%2Fwww.aspergillus.org.uk%2 Fsecure%2Fimage_library%2Fbrain%2Fbrain9.htm&ei=e_iEUt6NOI_KsQSA4ICYCQ&psig=AFQjCNHhqOrrP6 HkPLnarpEOZm0-QGlF1g&ust= O 6JK- eUG5M:&ved=0CAcQjB0wADgT&url=http%3A%2F%2Fwww.lookfordiagnosis.com%2Fmesh_info.php%3Fter m%3DToxoplasmosis%252C%2BCerebral%26lang%3D1&ei=zviEUtW9JYXNsQTU04Aw&psig=AFQjCNHkXu QtjtH9MUyBFymy4YWZp9ISTQ&ust= O mj_6Z4nM:&ved=0CAcQjB0wAA&url=http%3A%2F%2Fwww.aspergillus.org.uk%2Fsecure%2Fimage_library %2Fflavus%2Fflavbal.html&ei=RwKFUqusI6_MsQSy7IKQCg&psig=AFQjCNEUPPecAbBSOZlvyU4zO75m4UG r4A&ust=

17 Photo References O wIZ6fM&tbnid=egpN1KV2oI8zJM:&ved=0CAcQjB0wAA&url=http%3A%2F%2Fwxgrj.en.alibaba.com%2Fprod uct%2F %2Fhigh_quality_beta_glucan_1_3_1_6_UV_80_.html&ei=CQOFUomwA7DIsASWqoDYBQ&psi g=AFQjCNG-BcYBuoHAyl-vwFQD74Uwm3Vp3w&ust= O W6ohe5eM:&ved=0CAcQjB0wAA&url=http%3A%2F%2Fmedlibes.com%2Fentry%2Finvasive- aspergillosis&ei=dQSFUtedFdTJsQTw84LQCA&psig=AFQjCNG8aXRbzcXqm1SYwSDeVs1zX1cAxw&ust= O ANFZ3ho1M:&ved=0CAcQjB0wADg3&url=http%3A%2F%2Fwww.bio-rad.com%2Fen- rs%2Fproduct%2Fdetection-aspergillus-galactomannan-antigen-eia-microplate- assays&ei=KwWFUoG_GLDlsAT_tYKQAg&psig=AFQjCNEJSnFYLp- mWQ6WD9hJ0Mlc3ytvnA&ust= O gGtKM:&ved=0CAcQjB0wADgU&url=http%3A%2F%2Fnorgenbiotek.com%2Fdisplay- product.php%3FID%3D277&ei=4gWFUs27ErLksASfoIDwBQ&psig=AFQjCNFCev0rRPCs_OdwKrLECrokmWjh YA&ust= O IO84xxSM:&ved=0CAcQjB0wAA&url=http%3A%2F%2Fwww.pc.maricopa.edu%2FBiology%2Frcotter%2FBIO % %2FLessonBuilders%2FChapter%252012%2520LB%2FRevisedCh12LessonBuilder_print.html &ei=ZwaFUozeGtLnsASZyYLgCw&psig=AFQjCNGAOm6wi-G-si- pg8y1wP1XEg1a3A&ust=

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