1. Pawel Olko, IEEE meeting, 30.06.2008 1 The Henryk Niewodnicza ń ski Institute of Nuclear Physics Polish Academy of Sciences, IFJ PAN

2. Pawel Olko, IEEE meeting, 30.06.2008 2 History of the institute Pioneer measurements of cosmic rays, discovered the anisotropy of the viscosity in liquid crystals Prof. Marian Mięsowicz 1907-1992 Prof. Henryk Niewodniczański (1900-1968) Nuclear physicist, first director of IFJ

3. Pawel Olko, IEEE meeting, 30.06.2008 3 General information on IFJ PAN - 450 personnel (~190 with Ph.D.) - 17 departments / 5 divisions - centres of excellence - centres of advanced technology - accredited laboratories - technical sections - PhD studies (72 students)

4. Pawel Olko, IEEE meeting, 30.06.2008 4 Organigram of the IFJ PAN Prof. M.Jezabek General Director

5. Pawel Olko, IEEE meeting, 30.06.2008 5 Personnel

6. Pawel Olko, IEEE meeting, 30.06.2008 6 IFJ PAN Plans (2008-2016) DESY –ZEUS/H1 CERN –ATLAS –LHCb KEKB ILC Pierre Auger Neutrinos –T2K –SUNLAB (Sieroszowice) Particle & Astroparticle Physics

7. Pawel Olko, IEEE meeting, 30.06.2008 7 IFJ PAN Plans (2008-2016) RHIC CERN: –ALICE –ATLAS FAIR (GSI) SPIRAL2 (GANIL) Nuclear Physics & Strong Interactions

8. Pawel Olko, IEEE meeting, 30.06.2008 8 Nuclear Energy and Safety Nuclear technology & enviromental monitoring and dosimetry –Accredited Laboratories of:  Individual and Enviromental Dosimetry  Radiometric Expertise  Radioactivity Analysis –Education in collab. with AGH UST –High Temperature Reactor Thermonuclear energy –Stelarator WX7 (Greifswald) –ITER (neutron transport and cross section measurements)

9. Pawel Olko, IEEE meeting, 30.06.2008 9 Life Science Cluster in Kraków Radiobiology in IFJ PAN: –Van de Graaff accelerator: p microbeam –X microbeam –Isochronous cyclotron AIC-144 –NMR Imaging system Collaboration with JINR Dubna Proton radiotherapy projects –eye melanoma (firts patient 2009) – all localisations (2013)

10. Pawel Olko, IEEE meeting, 30.06.2008 10 Cyclotrons at IFJ PAN - first cyclotron in Poland developed by IFJ, 48 cm (1955) - classical cyclotron U-120 (opened 22.11.1958, stopped 1994) -cyclotron isochronic AIC-144 (from 80’s) 59 MeV protons

11. Pawel Olko, IEEE meeting, 30.06.2008 11 Advantages of proton beam for cancer radiotherapy - well defined range of proton beam - small scattering - very precise irradiation

12. Pawel Olko, IEEE meeting, 30.06.2008 12 PROJECT OF THE PROTON OCULAR RADIOTHERAPY AT IFJ Eye melanoma - malignant tumor - proton therapy allows to save the eye globe and the useful vision - survival 95% -Clinic of Ophthalmology and Ophthalmic Oncology in Krakow treats 95% of ocular melanoma cases in Poland -Currently: surgery, laser, Ru-106 and I-125 brachytherapy - 150 new patients per year

13. Pawel Olko, IEEE meeting, 30.06.2008 13 Treatment room (year 2000) FACILITY Therapy room

14. Pawel Olko, IEEE meeting, 30.06.2008 14 The therapy room at IFJ Kraków

15. Pawel Olko, IEEE meeting, 30.06.2008 15 PROJECT OF THE PROTON OCULAR RADIOTHERAPY AT IFJ Timetable 1994 - first proposal 1996 - beginning of installation of AIC-144 cyclotron; 2000 - construction of the treatment room; 04.2004 - 44 MeV proton beam delivered to treatment room; 06.2005 - 56 MeV proton beam delivered to the treatment room; 2006-2007 - purchasing of medical equipment and upgrading the AIC-144 cyclotron 2008 - 60 MeV proton beam, commissioning 2009 - first patient

16. Pawel Olko, IEEE meeting, 30.06.2008 16 EU Structural Funds 2005-2006 Division of Applied Physics and Interdisciplinary Research

17. Pawel Olko, IEEE meeting, 30.06.2008 17 EU Structural Funds 2007-2013 Division of Applied Physics and Interdisciplinary Research

18. Pawel Olko, IEEE meeting, 30.06.2008 18 Consortium National Centre of Hadron Radiotherapy NCRH Grounded: 12.09.2006 IFJ PAN Kraków – coordinator Akademia Górniczo-Hutnicza Medical University, Warszawa, Center of Oncology, Warszawa Center of Oncology, Krakow Holycross Center of Oncology, Kielce Institute of Nuclear Problems, Warszawa Warsaw Polytechnic Silesia University Warsaw University

19. Pawel Olko, IEEE meeting, 30.06.2008 19 NCRH Phase I (Krakow) preliminarily approved Source: structural funds of EU for Poland 2007-2013 IFJ has 10,000 m 2 of terrain for construction of new facility Timescale: 2008-2013 Agreement signed with the Ministry of Science 16.10.2007

20. Pawel Olko, IEEE meeting, 30.06.2008 20 For currently available funds: 1. Cyclotron (230-250 MeV) 2. Energy selector 3. Beam transport 4. Bunker with the experimental hall 5. Eye-therapy room (moved from AIC-144) 6. Small laboratory building NCRH Phase I (Krakow) preliminarily approved From presentation of J. Heese, Varian -Accel

21. Pawel Olko, IEEE meeting, 30.06.2008 21 NCRH Phase I timetable Decision for the localization 05.2008 Announcement of the main tender 02.2009 Signing the contract 11.2009 Building permit 12.2010 Building completed 06.2012 Cyclotron operational09.2013

22. Pawel Olko, IEEE meeting, 30.06.2008 22 Installation of gantry for patient treatment  Gantry is rotating arm able to move the proton beam around the patient  Gantry allows for radiotherapy in arbitrary localization  Very good conformation of dose  The application for the installing gantry will be submitted Proton beam pacjent 11 metrów patient 11 meters

23. Pawel Olko, IEEE meeting, 30.06.2008 23 Final set-up with therapeutic gantry

24. Pawel Olko, IEEE meeting, 30.06.2008 24 Summary of proton radiotherapy 1.Eye melanoma proton radiotherapy starts at IFJ Krakow in May 2009. 60 MeV proton beam will be delivered by AIC- 144 cyclotron. Cooperation with Clinic of Ophthalmology and Centre of Oncology 2.The project National Centre for Hadron Radiotherapy Phase 1 has been approved. 230-250 MeV cyclotron will be purchased, new cyclotron bunker and experimental hall will be constructed, eye treatment moved 3.The funds for the gantry have to be generated