Presentation on theme: "DELIVERY OF AEROSOLIZED DRUGS THROUGH CONTINUOUS POSITIVE AIRWAY PRESSURE (CPAP) Team Patrick Kurkiewicz Annie Loevinger Joe Decker Steve Welch Client."— Presentation transcript:
DELIVERY OF AEROSOLIZED DRUGS THROUGH CONTINUOUS POSITIVE AIRWAY PRESSURE (CPAP) Team Patrick Kurkiewicz Annie Loevinger Joe Decker Steve Welch Client Dr. Mihai Teodorescu Advisor Professor John Webster
Outline Problem Statement Background Information Client Specifications Design Options Design 1: Jet Nebulizer Design 2: Ultrasonic Nebulizer with One-Way Valve Design 3: Ultrasonic Nebulizer with Flow Sensor Final Design Future Work Questions
Problem Statement A method is needed for automated delivery of bronchodilator drugs, like Albuterol, while using the CPAP device. Automated delivery should either be continuous or at timed intervals over a patient’s sleep cycle.
Background Continuous Positive Airway Pressure (CPAP) Used for sleep apnea and asthma patients Provides positive pressure to assist breathing Image from Webster, J.G Medical Instrumentation.
Background Uses Pressurized Air Efficiency 39+/-3%** Uses ultrasonic waves Efficiency 86+/-5%** Jet NebulizerUltrasonic Nebulizer Image from ** Gessler T; Schmehl T; Hoeper M M; Rose F; Ghofrani H A; Olschewski H; Grimminger F; Seeger W Ultrasonic versus jet nebulization of iloprost in severe pulmonary hypertension. The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2001;17(1):14-9. Image from Nebulizer: transforms liquid medication into mist patient
Client Specifications Compatible with CPAP Automatically deliver albuterol sulfate Cannot compromise quality of sleep Design for clinical trials Made for adults Prototype can be computer interface
Design 1: Jet Nebulizer in-line with CPAP + Simple + Inexpensive - Loud - Requires separate flow generation
Design 2: Ultrasonic Nebulizer with One-Way Valve Nebulizer gas collects in side chamber during exhale, taken up during inhale + Simple design - Collecting gas may re-condense
Design 3: Ultrasonic Nebulizer with Flow Sensor Flow sensor detects breathing rate, turns nebulizer on/off based on inhalation cycle + More control - Complicated, requires more parts
Design Matrix Efficacy (25) Safety (20) Compatibility /Feasibility (20) Patient Comfort (20) Ease of Use (10) Cost (5) Total (100) Jet Nebulizer Ultrasonic One-Way Valve Ultrasonic Flow Sensor
Final Design Ultrasonic nebulizer with one-way valve control Existing CPAP and mask Added programmable controls
Future Work Finish proof of concept testing Construct prototype nebulizer Prototype testing Drug delivery Control efficacy Integrate design with CPAP