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Synthesis and characterization of photosensitizers to be used in photodynamic therapy.

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Presentation on theme: "Synthesis and characterization of photosensitizers to be used in photodynamic therapy."— Presentation transcript:

1 Synthesis and characterization of photosensitizers to be used in photodynamic therapy

2 Contacts Department of Chemistry, Phisics and Environment, University of Udine Dr. Clara Comuzzi, Via del Cotonificio Udine Tel: /8874; Fax:

3 The team Dr. Clara Comuzzi Photosesitizers synthesis and PDT/PACT therapy expert. Dr. Silvia Cavalli Nanomaterial synhesis and engineering expert. Dr. Sabina Susmel Electrochemical sensors/biosensors development expert. Ing. Dr. Daniele Goi Environmental sanitary engineering expert. Dr. Giada Rossi Water sanitary treatment expert.

4 Photodynamic therapy: mechanisms of action

5 Photosensitzer (active principle) Fe 2 O 3 Tumoral cells, Gram+ and Gram- bacteria, S. Aureus methicillin- resistant (MRSA) Applications

6 Biocidal global market Turnover 2008 : 7 bilion dollars (Source: BCC research) Annual growth rate : 10% Leading sector: treatment of antibiotic-resistant bacteria infections Market profile

7 The pain Emerging infections caused by antibiotic resistant bacterial strains. An example has been the “Shiga toxin-producing E. coli” recently isolated in Germany. Sanitization demand of surfaces, water, food,...

8 The product Active principle, based on a “switch on/off” mechanism due to light radiation. Patent applied for but not yet granted: PCT/IB2011/

9 Competition factors Innovative disinfection technique: It doesn't induce resistance. The photosensitizer is dispersed in water without its solubilization. Side effects are decreased thanks to the on/off mechanisms of the active principle. There is no corrosion damage on metal surfaces.


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