Intro: Anecdotal reports suggested mood improvement in bipolar disorder immediately after EPMRSI Aim: evaluate mood improvement associated EPMRSI
Methods: 3 treatment groups: BD active (n=30), BD sham (n=10), HC active (n=14) subjects were blinded to the hypothesis (EPMRSI causes mood change) Brief Affect Scale, Hamilton Depression Rating Scale, Young Mania Rating Scale (by same research assistant) rater was not blinded to the treatment conditions
Intro: paper by Rohan Aim: evaluate effects in behavioural tasks in rats
Methods: rats received LFMS (three 20-min sessions at 1.5 G/cm and.75 V/m) before behavioral testing immobility in the forced swim test activity within an open field fear conditioning
114 male rats head gradient coil: a development prototype(Advanced NMR Systems, Woburn, Massachusetts) comprising a cylinder (diameter, 35.56 cm; length, 45.72 cm; thickness, 1.59 cm) with three embedded magnetic coils
control of the waveform by LabVIEW switching amplifier (MTS Automation, Horsham, Pennsylvania) magnetic field gradient strength for this experiment was 1.5 G/cm 2A), and the electric field strength at the coil center was.75 V/m right-to-left electric field was delivered in 0.250 ms square pulses @ 1 kHz pulse polarity alternated With gradient design and analysis software, electric field distributions for the LFMS gradient coils were calculated with a Biot-Savart style integration of simulated coil design files containing three-dimensional wire information with a.5-cm linear resolution.
Results: magnetic stimulation reduced immobility in the forced swimming task –an antidepressant-like effect –qualitatively similar to that of standard antidepressants magnetic stimulation did not alter: –locomotor activity –fear conditioning
Discussion: Low-field magnetic stimulation has antidepressant-like effects in rats electromagnetic fields affect the brain novel approaches to therapy for psychiatric disorders MRI scans are less inert than previously thought
“ TMS project ” arbitrary waveshapes and frequency content up to 6 G (0.6 mT) (like EPMRSI) one channel for 19 electromagnets clinical trial ongoing, analgesic effects individual switching being implemented four independent channels being implemented find evidence for EEG entrainment with TMS
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