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Brain Structural and Functional Changes Associated with Addiction and Recovery Qinghua He, Ph.D. Associate Professor Southwest University, Chongqing, China.

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Presentation on theme: "Brain Structural and Functional Changes Associated with Addiction and Recovery Qinghua He, Ph.D. Associate Professor Southwest University, Chongqing, China."— Presentation transcript:

1 Brain Structural and Functional Changes Associated with Addiction and Recovery Qinghua He, Ph.D. Associate Professor Southwest University, Chongqing, China

2 Agenda Addiction and its underlying neural mechanism MRI and fMRI background Structural and Functional changes associated with Food Addiction Structural and Functional changes associated with Facebook Addiction Structural and Functional changes associated with Cocaine Addiction and Recovery

3 Agenda Addiction and its underlying neural mechanism

4 Addiction Substance Dependence Cocaine; Heroin; Methamphetamine; Nicotine; etc. Behavior Addiction Internet Addiction; Overeating; Pathological gambling; Compulsive shopping; etc.

5 Neural Mechanisms underlying Addiction Noel, Brevers, Bechara, 2013, Current Opinions in Nueorbiology

6 Agenda Addiction and its underlying neural mechanism MRI and fMRI background

7 MRI scanner Superconducting 1-7 Tesla for human magnets

8 f/MRI scanning Source: http://www.cis.rit.edu/class/schp730/lect/lect-2.htm

9 Gray Matter Analysis Source: http://www.martinos.org/neurorecovery/technology.htm

10 Borrowed from FSL Course 2012, Bristol, UK

11 Agenda Addiction and its underlying neural mechanism MRI and fMRI background Structural and Functional changes associated with Food Addiction

12 Food Addiction Compulsive eating Binge eating Obesity

13 Brain Structure Bases He et al., 2015, Brain Structure and Function

14 Brain Structure Bases He et al., 2015, Brain Structure and Function

15 Brain Structure Bases He et al., 2015, Brain Structure and Function

16 Brain Structure Bases Regression Analysis all three factors made unique contributions to BMI Mediation Analysis IGT score in the first 40 trials mediated the association between GMV in the MCC region and BMI (indirect effect = -0.23, p<0.05) as well as between the number of white matter tracks passing this region and BMI (indirect effect = -0.27, p<0.05). He et al., 2015, Brain Structure and Function

17 Functional Bases He et al., 2014, Nutrition Journal

18 Functional Bases He et al., 2014, Nutrition Journal

19 Functional Bases He et al., 2014, Nutrition Journal

20 Functional Bases He et al., 2014, Frontiers in Neuroscience

21 Functional Bases He et al., 2014, Frontiers in Neuroscience

22 Food Addiction Impulsive System Hyper-active Inhibition Control System Hypo-active

23 Agenda Addiction and its underlying neural mechanism MRI and fMRI background Structural and Functional changes associated with Food Addiction Structural and Functional changes associated with Facebook Addiction

24 Facebook Addiction Turel & He et al., 2014, Psychological Reports

25 Facebook Addiction Turel & He et al., 2014, Psychological Reports

26 Facebook Addiction Turel & He et al., 2014, Psychological Reports

27 Facebook Addiction Impulsive System Hyper-active Control System Maybe intact

28 Agenda Addiction and its underlying neural mechanism MRI and fMRI background Structural and Functional changes associated with Food Addiction Structural and Functional changes associated with Facebook Addiction Structural and Functional changes associated with Cocaine Addiction and Recovery

29 The Cocaine study

30 Purpose Combine fMRI, sMRI and DTI to understand the neurocognitive mechanism and recovery of drug addiction sMRI Gray matter volume, cortical thickness DTI White matter tractography fMRI Cue Task Cup Task Resting State

31 Method Summary Group Difference A VS Controls; difference between users and control A VS D | A VS BCD effects of recover D VS Controls the brain region not showing recover Correlation with Years of recovery PositiveNegative

32 Cue Task (BOLD) Cocaine-related pictures VS Nature pictures Block design

33 Cocaine Addiction Actually, the ACC activation showed a positive activation with recover; but VMPFC does not The activation of ACC seems recover But the activation of the VMPFC never recover

34 Summary Substance Addiction is like a brain disease Some of the brain function were damaged permanently Some functions could recover Different neural systems were engaged in different types of addictions Impulsive system mostly engaged in the Facebook Addiction Impulsive system and reflective system engaged in the food Addiction The decision making process doesn’t seem to recover in Cocaine Addiction

35 Acknowledgements UCLA Prof. Yih-Ing Hser USC Prof. Antoine Bechara Dr. Lin Xiao Beijing Normal University Prof. Qi Dong Prof. Gui Xue Dr. Chunhui Chen UC Irvine Prof. Chuansheng Chen The Ohio State University Prof. Zhong-Lin Lu Cal State Fullerton Prof. Ofir Turel

36 Questions?


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