1. Hotet från omvärlden ökar

2. Increased knowledge on an increasing problem number of hits in Pub-MED for (antibiotic or antimicrobial) + resistance by 5 year’s periods

3. MRSA in Europe 2004. Data from EARSS.

5. Crude estimate from Israel: 4% of all fatalities in hospitals related to Gram-neg multiresistant nosocomial inf. (Carmeli 2005) Crude estimate from EU-15: 5,800 excess deaths in ICU related to resistance (Harbarth et al 2005) Rough estimate of global gonnorhoea treatment failure: 3 million cases annually (of total 62 million cases) (Tapsall 2005) The tip of the iceberg…

6. The Current Paradox AntibioticResistanceAntibioticResistanceDrugDevelopmentDrugDevelopment

7. Sveriges beredskap är god?

8. Sales of Antibiotics in the Nordic Countries 1978-2004 DDD/1000 inhabitants/day

10. www.reactgroup.org

11. Sveriges beredskap är god? Optimal sjukhusanvändning? Optimal kinolonanvändning? Optimal diagnostik? Optimal hygien? Optimal profylax?

14. Guidelines does not work unless they are implemented ! Implementation does not work unless there is local comittment and educational outreach !