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1 Yale-UCL Senior Scientist Lecture Series, 2011 Mark Marsh LMCB, MRC Cell Biology Unit & Department of Developmental Biology, UCL.

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Presentation on theme: "1 Yale-UCL Senior Scientist Lecture Series, 2011 Mark Marsh LMCB, MRC Cell Biology Unit & Department of Developmental Biology, UCL."— Presentation transcript:

1 1 Yale-UCL Senior Scientist Lecture Series, 2011 Mark Marsh LMCB, MRC Cell Biology Unit & Department of Developmental Biology, UCL

2 School of Life and Medical Sciences SLMS has 2,562 members of research and academic staff. UCL was ranked 4 th for medicine in the 2011 Guardian University guide. UCL has one of England’s five Comprehensive Biomedical Research Centres. UCL Partners is one of the UK’s five Academic Health Science Centres. The Medical Research Council granted UCL the largest amount of funding and highest number of awards in 2008/2009. In the 2008 Research Assessment Exercise, 70–80% of research in the Life and Medical Sciences was graded as 3* or 4* SLMS boasts the UK’s strongest medical research grouping (research power score, RAE 2008)

3 SLMS domains BASIC RESEARCH SCIENCE INFECT. / IMM. / INFLAM. REPRO & DEVELPMNT. FRONTIER DISCIPLINES KNOWLEDGE TRANSFERPARTNERSHIPSDISCOVERY SCIENCEPOPULATION HEALTH EXPERIMENTAL MEDICINE EDUCATION NEUROSCI.CANCER CARDIO METABOLIC

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5 UKCMRI UK Centre for Medical Research and Innovation A world-class centre for interdisciplinary medical sciences, research and innovation Situated at the heart of a cluster of scientific excellence in central London A partnership of four of the world’s leading medical research organisations: –Medical Research Council, –Cancer Research UK –Wellcome Trust –UCL Bringing together two of the country’s leading centres of medical research: –National Institute for Medical Research –London Research Institute

6 UCL Faculty of Life Sciences Division of Biomedicine Genetics, Evolution and Environment Neuroscience, Physiology and Pharmacology Structural and Molecular Biology Cell and Developmental Biology Laboratory for Molecular Cell Biology

7 Receptor/ channel/ transporter & signaling molecules: Attwell, Beato, Cull-Candy, Dolphin, Farrant, Gibb, Kittler, Schoepfer, Sivilotti, Smart, Vergani. Structure-function: Millar, Sivilotti, Smart Central synaptic transmission & glia: Attwell, Cull-Candy, Beato, Sihra Healthy/ diseased states (channelopathies, animal models) Stanford, Sivilotti, Schoepfer, Smart Department of Neuroscience, Physiology & Pharmacology http://www.ucl.ac.uk/npp/index.html Dept has an outstanding history of research on receptors, ion channels and synaptic transmission. Highest ranked UK Department for ‘ World-leading research’ RAE2008 (UoA15) Cellular & Molecular Neuroscience

8 Systems Neuroscience Neural connectivity/ computation Mysic-Flogel, Hausser, Silver In vivo transfection/ optogenetics Mysic-Flogel, Hausser, Sjostrom Systems/ translational neuroscience of pain- London Pain Consortium Fitzgerald, Dickenson, Wood Linking cellular/ neural networks to behaviour Hausser, Mysic-Flogel, Sjostrom, Yeo Department of Neuroscience, Physiology & Pharmacology(2)

9 Department of Neuroscience, Physiology & Pharmacology(3) Cell signalling G-protein coupled receptor signaling Brown, Dolphin, Pitcher, Moss, Pedarzani, Stocker, Smart Phospholipid-dependent & NO signaling Cockcroft, Garthwaite Signal transduction in cardiovascular and immune systems. Willis, Hobbs Autonomic control of respiration & CVS Gilbey, Gourine, Ramage

10 Major research themes Centre for Stem Cell and Regenerative Medicine (Claudio Stern) Zebrafish research community - one of Europe’s largest fish research facilities, studying many aspects of developmental biology (Steve Wilson) Learning and Centre for Cell and Molecular Dynamic contains UCL’s core imaging facility and houses labs which study: –Wound healing (Becker) –Circadian clocks (Whitmore) –Neural Development (Salinas) Neural development and spatial learning and memory studies include: –Cortical development (Parnavalas) –Wnt Signaling and synapse formation (Salinas) –Neural Crest (Major, Mirsky, Jessen) –Spatial memory and learning (O’Keefe) Brings together more than 65 members of academic staff to study a wide range of cell and developmental problems. This includes aspects of stem cell biology, early embryo development, neural development and evolutionary (evo-devo) topics Cell and Developmental Biology

11 Genetics, Evolution and Environment GEE has several core strengths, including diversity, quantitative biology, genetics, healthy aging and graduate training. Human Genetics and Human Evolution (UCL Genetics Institute) Bradman; Povey; Thomas; Swallow; Maniatis; Ruiz-Linares; Balding; Plagnol; Jones; Wood; MacKay Evolution of development Telford; Bahler; Olivieri; Gems; Partridge; Smith; Lane; Wingler Systems biology (UCL Systems Biology) Bahler; Pomiankowski; Reuter; Schuster; Partridge; Gems; Lazaros; Olivieri Biology of Ageing (Institute of Healthy Ageing) Partridge; Gems; Foukas; Pearce; Schuster; Wingler Evolutionary Genetics Fowler; Partridge; Greig; Pomiankowski; Yang; Reuter; Mallet; Lane; Balding; Plagnol; Jones; Bahler; Thomas Biodiversity and environmental biology (Earth Sciences) Mallet; Day; Chatterjee; Goswami; Murrell; Telford; Pearson; Wotton; Wingler Computational biology (R. A. Fisher Centre for Computational Biology, CoMPLEX) Pomiankowski; Murrell; Maniatis; Thomas; Yang; Reuter; Balding; Plagnol; Chatterjee

12 Our strengths: Quantitative Biology R. A. Fisher Centre for Computational Biology population genetics, quantitative genetics, statistical inference, phylogenetics, QTL, transcriptomics CoMPLEX Interface maths/statistics/computation in life/medical sciences, mathematical modelling UCL Systems Biology Coordinating and strengthening interdisciplinary systems biology research across UCL Genetics, Evolution and Environment (2)

13 Our strengths: Centres of Excellence UCL Genetics Institute Applying bio-statistical and bio-informatic approaches to genetic research with a focus on clinical and human population genetics Institute of Healthy Ageing Bringing together researchers working on the basic biology of ageing and those working to understand the causes of ageing-related diseases Genetics, Evolution and Environment (3)

14 Our strengths: Graduate Training CoMPLEX Centre for Mathematics and Physics in the Life Sciences and Experimental Biology Doctoral Training Centre 15-20 MRes+PhD students / annum Funded by EPSRC, MRC, BHF, BBSRC, NERC Post-Doctoral Training Centre Starting April 2011, in collaboration with University of Oxford and Microsoft Research Genetics, Evolution and Environment (4)

15 The Department is a member of the Institute of Structural Molecular Biology (ISMB), which links UCL Departments of Chemistry and Structural and Molecular Biology, and the School of Crystallography at Birkbeck College Major research themes: –Bioanalytical Chemistry –Bioinformatics –Cell Signalling & Metabolic Regulation –Molecular Microbiology –Molecular Cell Biology –Structural Biology & Molecular Biophysics Structural and Molecular Biology

16 16 MRC LABORATORY FOR MOLECULAR CELL BIOLOGY


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