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CHALLENGING THE CONCEPTS OF LOCALIZATION AND RECOVERY OF BRAIN FUNCTION ReCBIR – Research Centre for Brain Injury Rehabilitation UCN - The Unit for Cognitive.

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Presentation on theme: "CHALLENGING THE CONCEPTS OF LOCALIZATION AND RECOVERY OF BRAIN FUNCTION ReCBIR – Research Centre for Brain Injury Rehabilitation UCN - The Unit for Cognitive."— Presentation transcript:

1 CHALLENGING THE CONCEPTS OF LOCALIZATION AND RECOVERY OF BRAIN FUNCTION ReCBIR – Research Centre for Brain Injury Rehabilitation UCN - The Unit for Cognitive Neuroscience ReCBIR – Research Centre for Brain Injury Rehabilitation UCN - The Unit for Cognitive Neuroscience Neuroplasticitet og rehabilitering efter hjerneskade – hjerneskadens mekanismer og behandling Jesper Mogensen, Professor Head of UCN (The Unit for Cognitive Neuroscience), Dep. of Psychol., University of Copenhagen Director of ReCBIR (Research Centre for Brain Injury Rehabilitation)

2 UCN - The Unit for Cognitive Neuroscience ReCBIR – Research Centre for Brain Injury Rehabilitation 2 Den regionale specialisering af hjernen – funktionel lokalisation

3 UCN - The Unit for Cognitive Neuroscience ReCBIR – Research Centre for Brain Injury Rehabilitation 3 FULD FUNKTIONEL GENOPRETNING TRODS KOMPLET SKADE AF HJERNESTRUKTURER (ALLOCENTRISK PLACE LEARNING) Mogensen et al. Brain Research Bulletin, 2004

4 UCN - The Unit for Cognitive Neuroscience ReCBIR – Research Centre for Brain Injury Rehabilitation 4 ELLER GENOPRETNING? LOKALISATION ELLER? …

5 UCN - The Unit for Cognitive Neuroscience ReCBIR – Research Centre for Brain Injury Rehabilitation 5 ALGORITHMIC STRATEGIES ELEMENTARY FUNCTIONS NEURAL SUBSTRATES BEHAVIOUR X UNDERLYING COGNITIVE MECHANISMS AS A AS C EF 1 EF 2 EF 3 EF 4 EF 5 EF 6 EF 7 EF 8 EF 9 EF 10 EF 1 1 EF 12 EF 13 EF 14 EF 15 I II III IVV VI VII VIII IX X XI XII XIII XIV XV Brain structure α Brain structure β Brain structure γ UNDERLYING NEURAL MECHANISMS

6 UCN - The Unit for Cognitive Neuroscience ReCBIR – Research Centre for Brain Injury Rehabilitation 6 BDNF (Brain-Derived Neurotrophic Factor) samt andre trofiske faktorer …

7 UCN - The Unit for Cognitive Neuroscience ReCBIR – Research Centre for Brain Injury Rehabilitation 7 TROFISKE FAKTORER

8 UCN - The Unit for Cognitive Neuroscience ReCBIR – Research Centre for Brain Injury Rehabilitation 8 SPROUTING

9 UCN - The Unit for Cognitive Neuroscience ReCBIR – Research Centre for Brain Injury Rehabilitation 9 MEKANISMER for NEURONDØD

10 UCN - The Unit for Cognitive Neuroscience ReCBIR – Research Centre for Brain Injury Rehabilitation 10 BDNF og antidepressiva

11 UCN - The Unit for Cognitive Neuroscience ReCBIR – Research Centre for Brain Injury Rehabilitation 11 HVAD PÅVIRKER HJERNENS PLASICITET? BDNF?

12 UCN - The Unit for Cognitive Neuroscience ReCBIR – Research Centre for Brain Injury Rehabilitation 12 BDNF (Brain-Derived Neurotrophic Factor) samt andre trofiske faktorer ved hjerneskade Betydning i den akutte fase Betydning for langsigtet reorganisering

13 UCN - The Unit for Cognitive Neuroscience ReCBIR – Research Centre for Brain Injury Rehabilitation 13 SKADER ved BLODPROP

14 UCN - The Unit for Cognitive Neuroscience ReCBIR – Research Centre for Brain Injury Rehabilitation 14 MEKANISMER for NEURONSKADE ved TBI

15 UCN - The Unit for Cognitive Neuroscience ReCBIR – Research Centre for Brain Injury Rehabilitation 15 BDNF (Brain-Derived Neurotrophic Factor) samt andre trofiske faktorer ved hjerneskade Betydning i den akutte fase Betydning for langsigtet reorganisering

16 UCN - The Unit for Cognitive Neuroscience ReCBIR – Research Centre for Brain Injury Rehabilitation 16 Hvordan kan BDNF fremmes ?

17 UCN - The Unit for Cognitive Neuroscience ReCBIR – Research Centre for Brain Injury Rehabilitation 17 BDNF og antidepressiva

18 UCN - The Unit for Cognitive Neuroscience ReCBIR – Research Centre for Brain Injury Rehabilitation 18 Hvordan kan BDNF fremmes ? – andre muligheder?

19 UCN - The Unit for Cognitive Neuroscience ReCBIR – Research Centre for Brain Injury Rehabilitation 19 BDNF ved motorisk aktivitet

20 UCN - The Unit for Cognitive Neuroscience ReCBIR – Research Centre for Brain Injury Rehabilitation 20 BDNF

21 UCN - The Unit for Cognitive Neuroscience ReCBIR – Research Centre for Brain Injury Rehabilitation 21

22 UCN - The Unit for Cognitive Neuroscience ReCBIR – Research Centre for Brain Injury Rehabilitation 22

23 UCN - The Unit for Cognitive Neuroscience ReCBIR – Research Centre for Brain Injury Rehabilitation 23 Food for Thought …

24 UCN - The Unit for Cognitive Neuroscience ReCBIR – Research Centre for Brain Injury Rehabilitation 24

25 UCN - The Unit for Cognitive Neuroscience ReCBIR – Research Centre for Brain Injury Rehabilitation 25

26 UCN - The Unit for Cognitive Neuroscience ReCBIR – Research Centre for Brain Injury Rehabilitation 26 HVAD PÅVIRKER HJERNENS PLASICITET? Motion?

27 UCN - The Unit for Cognitive Neuroscience ReCBIR – Research Centre for Brain Injury Rehabilitation 27 Aktivering/stimulation som terapeutisk metode ved hjerneskade

28 UCN - The Unit for Cognitive Neuroscience ReCBIR – Research Centre for Brain Injury Rehabilitation 28

29 UCN - The Unit for Cognitive Neuroscience ReCBIR – Research Centre for Brain Injury Rehabilitation 29

30 UCN - The Unit for Cognitive Neuroscience ReCBIR – Research Centre for Brain Injury Rehabilitation 30 Tidlig eller sen ?

31 UCN - The Unit for Cognitive Neuroscience ReCBIR – Research Centre for Brain Injury Rehabilitation 31

32 UCN - The Unit for Cognitive Neuroscience ReCBIR – Research Centre for Brain Injury Rehabilitation 32

33 UCN - The Unit for Cognitive Neuroscience ReCBIR – Research Centre for Brain Injury Rehabilitation 33

34 UCN - The Unit for Cognitive Neuroscience ReCBIR – Research Centre for Brain Injury Rehabilitation 34 SEN ! Men …

35 UCN - The Unit for Cognitive Neuroscience ReCBIR – Research Centre for Brain Injury Rehabilitation 35 Aktivering/stimulation som terapeutisk metode ved hjerneskade

36 UCN - The Unit for Cognitive Neuroscience ReCBIR – Research Centre for Brain Injury Rehabilitation 36 Påtvunget eller frivillig ? Stress ?

37 UCN - The Unit for Cognitive Neuroscience ReCBIR – Research Centre for Brain Injury Rehabilitation 37

38 UCN - The Unit for Cognitive Neuroscience ReCBIR – Research Centre for Brain Injury Rehabilitation 38

39 UCN - The Unit for Cognitive Neuroscience ReCBIR – Research Centre for Brain Injury Rehabilitation 39 Exercise after stress

40 UCN - The Unit for Cognitive Neuroscience ReCBIR – Research Centre for Brain Injury Rehabilitation 40 FRIVILLIG ! Men …

41 UCN - The Unit for Cognitive Neuroscience ReCBIR – Research Centre for Brain Injury Rehabilitation 41 Aktivering/stimulation som terapeutisk metode ved hjerneskade

42 UCN - The Unit for Cognitive Neuroscience ReCBIR – Research Centre for Brain Injury Rehabilitation 42

43 UCN - The Unit for Cognitive Neuroscience ReCBIR – Research Centre for Brain Injury Rehabilitation 43

44 UCN - The Unit for Cognitive Neuroscience ReCBIR – Research Centre for Brain Injury Rehabilitation 44 Betydningen af stress

45 UCN - The Unit for Cognitive Neuroscience ReCBIR – Research Centre for Brain Injury Rehabilitation 45

46 UCN - The Unit for Cognitive Neuroscience ReCBIR – Research Centre for Brain Injury Rehabilitation 46

47 UCN - The Unit for Cognitive Neuroscience ReCBIR – Research Centre for Brain Injury Rehabilitation 47 Støtte til funktionel genopretning og træning – samt måske ”skader” ved psykiske lidelser Farmakologi Aktivering/Stimulering

48 UCN - The Unit for Cognitive Neuroscience ReCBIR – Research Centre for Brain Injury Rehabilitation 48 Farmakologisk støttet rehabilitering

49 UCN - The Unit for Cognitive Neuroscience ReCBIR – Research Centre for Brain Injury Rehabilitation 49

50 UCN - The Unit for Cognitive Neuroscience ReCBIR – Research Centre for Brain Injury Rehabilitation 50 Farmakologisk støttet rehabilitering Effekter af Erythropoietin (EPO)

51 UCN - The Unit for Cognitive Neuroscience ReCBIR – Research Centre for Brain Injury Rehabilitation 51 EPO og BDNF

52 UCN - The Unit for Cognitive Neuroscience ReCBIR – Research Centre for Brain Injury Rehabilitation 52 7 dage 30 dage Interaktioner

53 UCN - The Unit for Cognitive Neuroscience ReCBIR – Research Centre for Brain Injury Rehabilitation 53 EPO og BDNF

54 UCN - The Unit for Cognitive Neuroscience ReCBIR – Research Centre for Brain Injury Rehabilitation 54 Glutamat Betydning i den akutte fase Betydning for langsigtet reorganisering

55 UCN - The Unit for Cognitive Neuroscience ReCBIR – Research Centre for Brain Injury Rehabilitation 55 SKADER ved BLODPROP

56 UCN - The Unit for Cognitive Neuroscience ReCBIR – Research Centre for Brain Injury Rehabilitation 56

57 UCN - The Unit for Cognitive Neuroscience ReCBIR – Research Centre for Brain Injury Rehabilitation 57 Glutamat - PIMSD

58 UCN - The Unit for Cognitive Neuroscience ReCBIR – Research Centre for Brain Injury Rehabilitation 58 DEN DYNAMISKE HJERNE: HÅB OG UDFORDRINGER

59 UCN - The Unit for Cognitive Neuroscience ReCBIR – Research Centre for Brain Injury Rehabilitation 59 Får vi en kopi af det mistede?

60 UCN - The Unit for Cognitive Neuroscience ReCBIR – Research Centre for Brain Injury Rehabilitation MODIFICATION OF DEGREE OF CONTRIBUTION TO TASK MEDIATION BY INDIVIDUAL STRUCTURES: Some structures exhibit increased or decreased levels of contribution to task mediation 2. TASK-DEPENDENT AND DISSIMILAR NEURAL SUBSTRATES: After a given lesion the functional recovery of various cognitive tasks is mediated by unique and dissimilar neural substrates 3. APPLICATION OF NEW COGNITIVE STRATEGIES: The fully posttraumatically recovered individuals solve the task by applying new strategies that are dissimilar to those applied pretraumatically PHENOMENA OF POSTTRAUMATIC RECOVERY

61 UCN - The Unit for Cognitive Neuroscience ReCBIR – Research Centre for Brain Injury Rehabilitation 61 ALGORITHMIC STRATEGIES ELEMENTARY FUNCTIONS NEURAL SUBSTRATES BEHAVIOUR X UNDERLYING COGNITIVE MECHANISMS AS A AS C EF 1 EF 2 EF 3 EF 4 EF 5 EF 6 EF 7 EF 8 EF 9 EF 10 EF 1 1 EF 12 EF 13 EF 14 EF 15 I II III IVV VI VII VIII IX X XI XII XIII XIV XV Brain structure α Brain structure β Brain structure γ UNDERLYING NEURAL MECHANISMS

62 UCN - The Unit for Cognitive Neuroscience ReCBIR – Research Centre for Brain Injury Rehabilitation 62

63 UCN - The Unit for Cognitive Neuroscience ReCBIR – Research Centre for Brain Injury Rehabilitation 63 Får vi en kopi af det mistede? NEJ! Men kunne vi få det?

64 UCN - The Unit for Cognitive Neuroscience ReCBIR – Research Centre for Brain Injury Rehabilitation 64 Hvordan er de basale netværk dannet oprindeligt?

65 UCN - The Unit for Cognitive Neuroscience ReCBIR – Research Centre for Brain Injury Rehabilitation 65

66 UCN - The Unit for Cognitive Neuroscience ReCBIR – Research Centre for Brain Injury Rehabilitation 66

67 UCN - The Unit for Cognitive Neuroscience ReCBIR – Research Centre for Brain Injury Rehabilitation 67 ”Kritiske” perioder under udviklingen

68 UCN - The Unit for Cognitive Neuroscience ReCBIR – Research Centre for Brain Injury Rehabilitation 68 CSPGs - stoffer fra gliaceller … CSPGs – chondroitin sulphate proteoglycans

69 UCN - The Unit for Cognitive Neuroscience ReCBIR – Research Centre for Brain Injury Rehabilitation 69 Og så er der låst … … eller er der?!

70 UCN - The Unit for Cognitive Neuroscience ReCBIR – Research Centre for Brain Injury Rehabilitation 70 NEUROGENESE I DEN VOKSNE HJERNE

71 UCN - The Unit for Cognitive Neuroscience ReCBIR – Research Centre for Brain Injury Rehabilitation 71

72 UCN - The Unit for Cognitive Neuroscience ReCBIR – Research Centre for Brain Injury Rehabilitation 72

73 UCN - The Unit for Cognitive Neuroscience ReCBIR – Research Centre for Brain Injury Rehabilitation 73 CSPGs

74 UCN - The Unit for Cognitive Neuroscience ReCBIR – Research Centre for Brain Injury Rehabilitation 74 Styrkelse af BDNF? Hæmning af CSPGs?

75 UCN - The Unit for Cognitive Neuroscience ReCBIR – Research Centre for Brain Injury Rehabilitation 75 Fordele – og farer Hæmning af CSPGs?

76 UCN - The Unit for Cognitive Neuroscience ReCBIR – Research Centre for Brain Injury Rehabilitation 76 Styrkelse af BDNF?

77 UCN - The Unit for Cognitive Neuroscience ReCBIR – Research Centre for Brain Injury Rehabilitation 77 Aktivering/stimulation som terapeutisk metode ved hjerneskade

78 UCN - The Unit for Cognitive Neuroscience ReCBIR – Research Centre for Brain Injury Rehabilitation 78

79 UCN - The Unit for Cognitive Neuroscience ReCBIR – Research Centre for Brain Injury Rehabilitation 79 Hvad kan vi gøre for at få den bedste omformning af hjernen?

80 UCN - The Unit for Cognitive Neuroscience ReCBIR – Research Centre for Brain Injury Rehabilitation 80 ALGORITHMIC STRATEGIES ELEMENTARY FUNCTIONS NEURAL SUBSTRATES BEHAVIOUR X UNDERLYING COGNITIVE MECHANISMS AS A AS C EF 1 EF 2 EF 3 EF 4 EF 5 EF 6 EF 7 EF 8 EF 9 EF 10 EF 1 1 EF 12 EF 13 EF 14 EF 15 I II III IVV VI VII VIII IX X XI XII XIII XIV XV Brain structure α Brain structure β Brain structure γ UNDERLYING NEURAL MECHANISMS

81 UCN - The Unit for Cognitive Neuroscience ReCBIR – Research Centre for Brain Injury Rehabilitation 81

82 UCN - The Unit for Cognitive Neuroscience ReCBIR – Research Centre for Brain Injury Rehabilitation 82 GENERALISERING … af træning?

83 UCN - The Unit for Cognitive Neuroscience ReCBIR – Research Centre for Brain Injury Rehabilitation 83 GENERALISERING … og kan vi få virkeligheden ind i træningen? kan vi få træningen ud i virkeligheden?

84 UCN - The Unit for Cognitive Neuroscience ReCBIR – Research Centre for Brain Injury Rehabilitation 84

85 UCN - The Unit for Cognitive Neuroscience ReCBIR – Research Centre for Brain Injury Rehabilitation 85

86 UCN - The Unit for Cognitive Neuroscience ReCBIR – Research Centre for Brain Injury Rehabilitation 86

87 UCN - The Unit for Cognitive Neuroscience ReCBIR – Research Centre for Brain Injury Rehabilitation 87

88 UCN - The Unit for Cognitive Neuroscience ReCBIR – Research Centre for Brain Injury Rehabilitation 88 Virkeligheden ind i træningen! Træningen ud i virkeligheden!

89 UCN - The Unit for Cognitive Neuroscience ReCBIR – Research Centre for Brain Injury Rehabilitation 89 DEN DYNAMISKE HJERNE: HÅB OG UDFORDRINGER

90 UCN - The Unit for Cognitive Neuroscience ReCBIR – Research Centre for Brain Injury Rehabilitation 90 I forskning og behandling – lad os gå direkte efter de optimale løsninger!

91 UCN - The Unit for Cognitive Neuroscience ReCBIR – Research Centre for Brain Injury Rehabilitation 91 TAK FOR I DAG!


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