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Allo-HLA reactivity of virus-specific memory T cells is common by Avital L. Amir, Lloyd J. A. D'Orsogna, Dave L. Roelen, Marleen M. van Loenen, Renate.

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Presentation on theme: "Allo-HLA reactivity of virus-specific memory T cells is common by Avital L. Amir, Lloyd J. A. D'Orsogna, Dave L. Roelen, Marleen M. van Loenen, Renate."— Presentation transcript:

1 Allo-HLA reactivity of virus-specific memory T cells is common by Avital L. Amir, Lloyd J. A. D'Orsogna, Dave L. Roelen, Marleen M. van Loenen, Renate S. Hagedoorn, Renate de Boer, Menno A. W. G. van der Hoorn, Michel G. D. Kester, Ilias I. N. Doxiadis, J. H. Frederik Falkenburg, Frans H. J. Claas, and Mirjam H. M. Heemskerk Blood Volume 115(15): April 15, 2010 ©2010 by American Society of Hematology

2 Alloreactivity of virus-specific T-cell lines. Avital L. Amir et al. Blood 2010;115: ©2010 by American Society of Hematology

3 Allo-HLA reactivity of virus-specific T-cell clones. Avital L. Amir et al. Blood 2010;115: ©2010 by American Society of Hematology

4 Variable allo-HLA recognition by T-cell clones with the same specificity but different TCR Vβ usage. Avital L. Amir et al. Blood 2010;115: ©2010 by American Society of Hematology

5 The potency of the alloreactivity exerted by virus-specific T cells. Avital L. Amir et al. Blood 2010;115: ©2010 by American Society of Hematology

6 One TCR complex mediates both virus specificity and allo-HLA reactivity. Avital L. Amir et al. Blood 2010;115: ©2010 by American Society of Hematology


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