Presentation is loading. Please wait.

Presentation is loading. Please wait.

Quinolone low-level resistance in Salmonellae and other Enterobacteriaceae Niels Frimodt-Møller National Center of Antimicrobials and Infection Control.

Similar presentations


Presentation on theme: "Quinolone low-level resistance in Salmonellae and other Enterobacteriaceae Niels Frimodt-Møller National Center of Antimicrobials and Infection Control."— Presentation transcript:

1 Quinolone low-level resistance in Salmonellae and other Enterobacteriaceae Niels Frimodt-Møller National Center of Antimicrobials and Infection Control Statens Serum Institut Copenhagen, Denmark

2 No. of Isolates MIC mg/l Breakpoints / interpretive zone diameters NCCLS: R  4; S  1 SRGA: R > 1; S < Nalidixic acid - Susceptible No mutations ( ) Nalidixic acid - Susceptible Not genotyped ( ) Nalidixic acid – Intermediate No mutations Nalidixic acid – Resistant No mutations Nalidixic acid - Resistant + mutations 160, Salmonella spp., nalidixic acid S-R and ciprofloxacin MIC Hartmann, Skov & Frimodt-Møller

3 Salmonella spp: MIC for nalidixan og ciprofloxacin bestemt med mikrotiter og Etest Hartmann, Skov & Frimodt-Møller

4 Salmonella spp. and quinolone resistance Hartmann, Skov & Frimodt-Møller

5 Salmonella spp. and quinolone resistance Hartmann, Skov & Frimodt-Møller

6 Salmonella spp. and quinolone resistance Hartmann, Skov & Frimodt-Møller

7 Salmonella spp. and quinolone resistance Hartmann, Skov & Frimodt-Møller

8 Salmonella spp. and quinolone resistance Hartmann, Skov & Frimodt-Møller

9 Ciprofloxacin-resistance in Salmonella: Clinical failures

10 Quinolone resistance in E. coli Ruiz et al. Diagn Microbiol Infect Dis 2002, 42: No. of Isolates Ciprofloxacin MIC Nalidixic acid MIC % Nal - R strains were Cip-R (0.25) but Nal-S -> None grew over their Cip-MIC

11 Quinolone resistance and Enterobacteriaceae High correlation between Nal-R and Cipro- I/R (and other quinolones) Cipro MIC > mg/l correlates with poor clinical outcome of Cipro treatment, i.e. Cipro-S should remain < mg/l Cipro-R and Nal-S occurs, but so far no clinical relevance A Nalidixic acid disk/tablet is a good screening method for Cipro-I/R


Download ppt "Quinolone low-level resistance in Salmonellae and other Enterobacteriaceae Niels Frimodt-Møller National Center of Antimicrobials and Infection Control."

Similar presentations


Ads by Google