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Chemical Reaction Engineering (CRE) is the field that studies the rates and mechanisms of chemical reactions and the design of the reactors in which they.

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Presentation on theme: "Chemical Reaction Engineering (CRE) is the field that studies the rates and mechanisms of chemical reactions and the design of the reactors in which they."— Presentation transcript:

1 Chemical Reaction Engineering (CRE) is the field that studies the rates and mechanisms of chemical reactions and the design of the reactors in which they take place. Lecture 16

2 Today’s lecture Enzyme Kinetics Noncompetitive Inhibition Bioreactors Monod Equation Yield Coefficients Washout 2

3 Last lecture A given enzyme can only catalyze only one reaction. Urea is decomposed by the enzyme urease, as shown below. Michaelis Menten Equation The corresponding mechanism is: 3

4 Lecture 16 - Bioreactors Nutrient ++ Products Nutrient ++ Products cells more cells 4

5 Bioreactors 5

6 6

7 7

8 inoculum t=0 time  8 Cells + Substrate  More Cells + Product

9 Bioreactors 9 Exponential Growth Phase Death Phase Stationar y Phase Lag Phase 0 time lnC c a)Phases of Bacteria growth: I. Lag II. Exponential III. StationaryIV. Death b) Monod growth rate law:

10 10 Mass Balances: Accumulation = In - Out + Growth - Death Bioreactors

11 Rate Laws: C p *= Product Concentration at which all metabolism ceases 11 Bioreactors

12 Stoichiometry: A.) Yield Coefficients B.) Maintenance 12 Bioreactors

13 v 0 C S0 V=V 0 vCCCSvCCCSC Volume=V 13 1) Mass balance:

14 Bioreactors 14

15 2) Rates: 3) Parameters: 15 Bioreactors

16 Polymath Setup 1.) d(C C )/d(t)=-D*C C +(r g -r d ) 2.) d(C S )/d(t)=-D*(C S0 -C S )-Y sg *r g -m*C C 3.) d(C P )/d(t)=-D*C P +Y PC *r g 4.) rg=(((1-(C P /C pstar ))**0.52)*mumax*(C S /(K S +C S ))*C C 5.) D=0.2 6.) k d = ) r d =k d *C C 8.) C S0 =250 9.) Y PC = ) m= ) mumax= ) Y SC = ) K S =1.7 16

17 Bioreactors – Chemostats - CSTRs 1. Steady State - Neglect Death Rate and Cell Maintenance 2. Cell 17

18 Bioreactors – Chemostats - CSTRs 3. Substrate 18

19 Bioreactors CSTR Washout C DWDW DC 19 Washout dilution rate

20 How does this figure relate to drinking a lot of fluids when you have an infection or cold? DC C DWDW D D maxprod 20 Maximum Product Flow Rate

21 End of Lecture 16 21


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