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LICHEN PLANUS LICHEN PLANUS BY DR.MAHESH MATHUR, MD,DVD,DCP(UK)

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Presentation on theme: "LICHEN PLANUS LICHEN PLANUS BY DR.MAHESH MATHUR, MD,DVD,DCP(UK)"— Presentation transcript:

1 LICHEN PLANUS LICHEN PLANUS BY DR.MAHESH MATHUR, MD,DVD,DCP(UK)

2 LICHEN PLANUS DIFINETION CHRINIC INFLAMMATORY DISEASE OF UNKNOW ETIOLOGY CHARECTRISED BY SHINY VIOLACEOUS ITCHY FLAT TOPPED PAPULAR LESIONS MORPHOLOGICALLY & HISTOLOGICALLY CHARECTERISED BY LIQUIFIED DEGENRATION OF BASAL CELL LAYER AND BAND LIKE LINEAR CELLULAR INFILTRATION IN DERMIS

3 INCIDENCE WORLD WIDE – MUCH MORE IN ASIAN COUNTRIES 1 TO 2 % OF ALL NEW CASES IN DERMATOLOGY CLINIC SKIN LESION SUBSIDES IN 50 % OF CASES IN 9 MONTHS AND 100% BY 18 MONTHS MUCOUS MEMBREANS INVOLVE IN 30 OT 70 % CASES NAIL INVOLMENT IN 10% OF CASES

4 PATHOGENESIS AUTOIMMUNE – INFILTRATION OF CD 4+ / CD 8+CELLS & INCREAS IN Langerhan’S CELLS NUMBER IN SKIN LESIONS FAMILIAL- HLA B7 -

5 CLINICAL TYPES HYPERTROPHICUS FOLLICULAR ACTINICUS PIGMENTOSUS ANULAR LINEAR GUTTATE NAIL- 15% MUCOSAL- 40 TO 60% ORAL PERIANAL ESOPHAGIAL GENITAL

6 TYPICAL LICHEN PLANUS

7 SHINY, VIOLACEOUS PAPULAR LESIONS

8 KOBNER’S PHENOMENON

9 WICHAM’S STRAIE

10 LICHEN PLANUS HYPERTROPHICUS

11

12 LICHEN PLANUS - BULLOSUS

13 BULLOUS LICHEN PLANUS

14 LICHEN PLANUS

15 ANNULAR LESION AT SHAFT OF PENIS

16 LICHEN PLANUS ACTINICUS

17 LICHEN PLANUS TROPICUS

18 LICHEN PLANOPILARIS

19 CICATRICAL ALOPECIA

20 LICHEN PLANS AT PALM

21 LICHEN PLANUS AT FOOT

22 LICHEN PLANUS-ORAL LESION

23 ORAL LICHEN PLANUS

24 LICHEN PLANUS AT TONGUE

25 LICHEN PLANUS -TONGUE

26 EROSIVE LICHEN PLANUS

27 PERI ANAL LICHEN PLANUS

28 LICHEN PLANUS – PERIANAL REGION

29 NAIL CHANGES IN LICHEN PLANUS

30 LICHEN PLANUS- NAILS

31 HISTOPATHOLOGY HYPERKERATOSIS HYPERGRANULOSIS ACANTHOSIS LIQUFYING DEGENERATION OF BASAL CELL LAYER EOSINOPHILIC CYTOID BODIES

32 HISTOPATHOLOGY HIGH MAGNIFICAITON

33 LICHEN PLANOPILARIS

34 IMMUNOFLOURACENCE IgG & C3 DEPOSITION AT DERMOEPIDERMAL JUNCTION

35 IMMUNOFLOURACENCE CYTOID BODIES IGM STAINING

36 DRUGS CASUUSING LICHENOID REACTION ANTIMALARIALS THIAZID DIURATICS ISONIAZID CHLORPROPAMID B-BLOCKERS KETOCONAZOLE NSADS ACE INHIBITORS TETRACYCLINE COLOURING AGENTS

37 LICHENOID DRUG RASH

38 TREATMENT & PROGNOSIS STEROIDS-TOPICAL & SYSTAMIC PUVA CYCLOSPOIN AZOTHIOPRIN


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