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Lecture 13 Dendrites: Function Rachel A. Kaplan and Elbert Heng 4.1.14.

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Presentation on theme: "Lecture 13 Dendrites: Function Rachel A. Kaplan and Elbert Heng 4.1.14."— Presentation transcript:

1 Lecture 13 Dendrites: Function Rachel A. Kaplan and Elbert Heng

2 Announcements We hope you had a nice break! We will have your exams graded to hand back to you by Thursday Please fill out the survey if you already haven’t

3 An Overview “Dendrites integrate subthreshold synaptic inputs and ultimately control neuronal output” Again, central thesis of neuroscience: neurons transmit information – Input is input to dendrites – Dendrites by their nature change input – Changed inputs are integrated by soma – Soma then outputs output Information is thus transmitted

4 Input to dendrite that reaches soma can be affected by... We’ve seen before: LEAKY CABLE STRUCTURE – Length constant – Time constant Both of these have implications for summation of inputs Resultantly: – Relative timing of inputs matters (this lecture doesn’t get into this) – Distance of synapse from soma matters

5 Solutions to the Leaky Cable Problem Passive properties of dendrites – Morphology adjustments – Large dendrites – Larger EPSPs Active properties of dendrites – Spiking!

6 PASSIVE PROPERTIES

7 Morphology The more resistance a dendrite provides, the more of the current and change in voltage will be transmitted farther. – (we learned this with length/time constant) As a result, it’s been shown that larger dendrites are thicker – But diameter can only increase by so much...

8 Larger Distal Inputs Distal synapses do produce larger distal inputs! – Greater magnitude so decay over distance does not as greatly affect input This is due to greater glutamate receptor density

9 ACTIVE PROPERTIES


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