Presentation on theme: "NUTRITION & PARKINSON’S DISEASE"— Presentation transcript:
1NUTRITION & PARKINSON’S DISEASE Laurie K Mischley, NDBastyr UniversityUniversity of WashingtonSeattle Integrative Medicine
2NOT A DIET! Not a trend, fad, or other temporary alteration GOALS: Become InformedUnderstand consequences of your actionsMake wiser decisions tomorrow than you made yesterday
3WHAT IS NUTRITION? Latin: to nourish We think of ourselves as self-containedseparate from our environmentMe I Environment
4“NO MAN IS AN ISLAND, ENTIRE OF ITSELF;” JOHN DONNE, ENGLISH POET MeEnvironmentNutrition is the study of the inter-dependence between health and the environment.
5NUTRIENTSAre the things provided by the environment, that encourage, support, and sustain function.i.e. gas, oil in a car.Environment:Sunlight provides vitamin DGut bugs provide immunomodulationFood provides vitamins, minerals
6NUTRIENTS Macro: Micro: Accessory: Fat, Protein, Carbohydrate, (Alcohol)Micro:VitaminsB-vits, Vit C, Vit A, Vit D, etc.MineralsCa, Mg, K, I, Li, Na, Mn, …. (not all minerals are nutrients)Accessory:Co-Q10, carnitine, cholesterol, …Which of these do we need? By definition, anything that we cannot synthesize in sufficient amounts to meet our needsThere are Independent Organizations and government declarations about need. (huge consequences for making it on the list.)ANTIOXIDANTS… are a function, not a molecule
7THAT WHICH PREVENTS… Prospective, Observational Studies (don’t tell about treating disease)THAT WHICH PREVENTS…
8PROTECTIVE AGAINST PD (THE PRUDENT DIET) High intakes of:FruitVegetablesLegumes (beans)Whole grains (rice, quinoa)NutsFishPoultryLow intake of:Saturated fat (cream, red meat, pork)Moderate intake of:AlcoholAm J Clin Nutr 2007;86:OBJECTIVE: We examined associations between dietary patterns and risk of PD in the Health Professionals Follow-Up Study ( ) and the Nurses' Health Study ( ).DESIGN: We included men and women free of PD at baseline and used principal components analysis to identify major dietary patterns and the Alternate Healthy Eating Index (AHEI) and the alternate Mediterranean Diet Score (aMed) to assess diet quality. Relative risks (RRs) were computed by using Cox proportional hazards models within each cohort and were pooled by using a random-effects model.
10DAIRYNurses’ Health Study (121000) & Health Professional Follow-up Study (51000)1.8x riskHonolulu Heart Program (7500 men)2.3x riskAmerican Cancer Society’s Cancer Prevention Study II Nutrition Cohort (57000 men, women)Up to 1.8x risk
11WHAT CONSTITUTES DAIRY? Milk, butter, cheese, cream, half & half, ice cream, sour cream, cottage cheese, cream cheese, yogurt, frozen yogurt, whey proteinWhy? WHO tracks pesticides via butter, hormones in breastmilk, common food allergen- inflammation?, neurotoxin in dair?PREVENTION FOR YOUR CHILDREN??Individuals who consume 3-6 servings of dairy per day have 60-80% greater risk of developing PD than those who rarely or never consume it.
13TEA (GREEN & BLACK)Consumption of 3+ cups/ day of tea delayed motor symptom onset by 7.7 years.Kandinov B, et al. Parkinsonism Relat Disord 2009;15(1):41-6
14But what if I already have the disease.? INTERVENTION STUDIES
15IF YOUR BELLY IS BIGGER THAN YOUR HIPS… THIS ONE’S FOR YOU. Calorie RestrictionAmerican’s tend to:Eat too muchEat for reasons other than to nourishCR is typically defined as 10-25% fewer calories than the average Western diet.
16CR CLINICAL TRIALS Proc Natl Acad Sci USA 2004;101:18171-76 Rhesus monkeys (Maswood N, et al) Natl Inst Aging30% CR x 6 mo prior to MPTPControlsBoth groups showed symptoms after MPTPAt 6 months:Significantly fewer symptoms in the CR groupSignificantly increased concentrations of GDNFIncreased survival of DA neurons (not stat sig)Proc Natl Acad Sci USA 2004;101:Doesn’t provide insight into whether CR may help those who already have the disease.DOES provide preventative strategy for those at increased risk.
18GOAL- CONCENTRATE NUTRIENTS Macro == caloriesFat, Protein, Carbohydrate, (Alcohol)Micro:VitaminsB-vits, Vit C, Vit A, Vit D, etc.Minerals:Ca, Mg, K, I, Li, Na, Mn, etc.Accessory:Co-Q10, carnitine, cholesterol, etc.Which of these do we need? By definition, anything that we cannot synthesize in sufficient amounts to meet our needsThere are Independent Organizations and government declarations about need. (huge consequences for making it on the list.)