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NUTRITION & PARKINSON’S DISEASE Laurie K Mischley, ND Bastyr University University of Washington Seattle Integrative Medicine.

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Presentation on theme: "NUTRITION & PARKINSON’S DISEASE Laurie K Mischley, ND Bastyr University University of Washington Seattle Integrative Medicine."— Presentation transcript:

1 NUTRITION & PARKINSON’S DISEASE Laurie K Mischley, ND Bastyr University University of Washington Seattle Integrative Medicine

2 NOT A DIET! Not a trend, fad, or other temporary alteration GOALS:  Become Informed  Understand consequences of your actions  Make wiser decisions tomorrow than you made yesterday

3 WHAT IS NUTRITION?  Latin: to nourish  We think of ourselves as self-contained separate from our environment Me I Environment

4 “NO MAN IS AN ISLAND, ENTIRE OF ITSELF;” JOHN DONNE, ENGLISH POET Me Environment Nutrition is the study of the inter-dependence between health and the environment.

5 NUTRIENTS  Are the things provided by the environment, that encourage, support, and sustain function.  i.e. gas, oil in a car. Environment: Sunlight provides vitamin D Gut bugs provide immunomodulation Food provides vitamins, minerals

6 NUTRIENTS  Macro:  Fat, Protein, Carbohydrate, (Alcohol)  Micro:  Vitamins  B-vits, Vit C, Vit A, Vit D, etc.  Minerals  Ca, Mg, K, I, Li, Na, Mn, …. (not all minerals are nutrients)  Accessory:  Co-Q10, carnitine, cholesterol, …

7 Prospective, Observational Studies (don’t tell about treating disease) THAT WHICH PREVENTS…

8 PROTECTIVE AGAINST PD (THE PRUDENT DIET)  High intakes of:  Fruit  Vegetables  Legumes (beans)  Whole grains (rice, quinoa)  Nuts  Fish  Poultry  Low intake of:  Saturated fat (cream, red meat, pork)  Moderate intake of:  Alcohol Am J Clin Nutr 2007;86:

9 WHAT FOODS WEREN’T PROTECTIVE? PRUDENT DIET  High intakes of:  Fruit, Vegetables  Legumes/ Nuts  Whole grains  Fish  Poultry  Moderate alcohol  Limited saturated fat WESTERN DIET  High intakes of:  Red meat  Processed meat  Refined grains  French fries  Desserts & sweets  High fat dairy products

10 DAIRY  Nurses’ Health Study (121000) & Health Professional Follow-up Study (51000)  1.8x risk  Honolulu Heart Program (7500 men)  2.3x risk  American Cancer Society’s Cancer Prevention Study II Nutrition Cohort (57000 men, women)  Up to 1.8x risk

11 WHAT CONSTITUTES DAIRY? Milk, butter, cheese, cream, half & half, ice cream, sour cream, cottage cheese, cream cheese, yogurt, frozen yogurt, whey protein Individuals who consume 3-6 servings of dairy per day have 60-80% greater risk of developing PD than those who rarely or never consume it.

12 RETROSPECTIVE STUDIES

13 TEA (GREEN & BLACK)  Consumption of 3+ cups/ day of tea delayed motor symptom onset by 7.7 years. Kandinov B, et al. Parkinsonism Relat Disord 2009;15(1):41-6

14 But what if I already have the disease.? INTERVENTION STUDIES

15 IF YOUR BELLY IS BIGGER THAN YOUR HIPS… THIS ONE’S FOR YOU. Calorie Restriction American’s tend to:  Eat too much  Eat for reasons other than to nourish CR is typically defined as 10-25% fewer calories than the average Western diet.

16 CR CLINICAL TRIALS Rhesus monkeys (Maswood N, et al) Natl Inst Aging  30% CR x 6 mo prior to MPTP  Controls  Both groups showed symptoms after MPTP  At 6 months: Significantly fewer symptoms in the CR group Significantly increased concentrations of GDNF Increased survival of DA neurons (not stat sig) Proc Natl Acad Sci USA 2004;101:

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18 GOAL- CONCENTRATE NUTRIENTS  Macro == calories  Fat, Protein, Carbohydrate, (Alcohol)  Micro:  Vitamins  B-vits, Vit C, Vit A, Vit D, etc.  Minerals:  Ca, Mg, K, I, Li, Na, Mn, etc.  Accessory:  Co-Q10, carnitine, cholesterol, etc.

19 LESS: Bread, pasta, pastries, fried foods, fats MORE: Veggies, Beans, Fish, Poultry, Fruit, Herbs & Spices

20 NUTRIENT DENSE FOODS:  Nutrient- Dense Foods (usually bright colors)  Kale, spinach, chard  Carrots, beets,  Tomatoes  Broccoli  Berries, cherries  Salmon, sardines, herring  Eggs  NOT nutrient-dense  Donuts  Potato chips  French fries  Bread  Pasta  Soda  Candy, sweets  Fast food  Ice cream

21 INCREASE DIETARY ANTIOXIDANTS (ORAC)  Pinto beans  Red kidney  Small red  Blueberry  Cranberry 8983  Artichoke hearts 7900  Walnuts 3846  Hazelnuts 2739  Whole grain bread 398  Popcorn 157  Ketchup 6

22 DHA (FISH OIL)  Anti-inflammatory, in general  Reduces dyskinesias Ann Neurol 2006;59:282–288

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24 A FEW WORDS ABOUT SUPPLEMENTS:  Purity  Potency  Access  Cost (vs. Prescriptions)  Insurance coverage  Benefit vs. Risk

25 THANKS!  WA APDA  Kadlec Neurological Resource Center  Teva


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