Presentation on theme: "NUTRITION & PARKINSON’S DISEASE Laurie K Mischley, ND Bastyr University University of Washington Seattle Integrative Medicine."— Presentation transcript:
NUTRITION & PARKINSON’S DISEASE Laurie K Mischley, ND Bastyr University University of Washington Seattle Integrative Medicine
NOT A DIET! Not a trend, fad, or other temporary alteration GOALS: Become Informed Understand consequences of your actions Make wiser decisions tomorrow than you made yesterday
WHAT IS NUTRITION? Latin: to nourish We think of ourselves as self-contained separate from our environment Me I Environment
“NO MAN IS AN ISLAND, ENTIRE OF ITSELF;” JOHN DONNE, ENGLISH POET Me Environment Nutrition is the study of the inter-dependence between health and the environment.
NUTRIENTS Are the things provided by the environment, that encourage, support, and sustain function. i.e. gas, oil in a car. Environment: Sunlight provides vitamin D Gut bugs provide immunomodulation Food provides vitamins, minerals
NUTRIENTS Macro: Fat, Protein, Carbohydrate, (Alcohol) Micro: Vitamins B-vits, Vit C, Vit A, Vit D, etc. Minerals Ca, Mg, K, I, Li, Na, Mn, …. (not all minerals are nutrients) Accessory: Co-Q10, carnitine, cholesterol, …
Prospective, Observational Studies (don’t tell about treating disease) THAT WHICH PREVENTS…
PROTECTIVE AGAINST PD (THE PRUDENT DIET) High intakes of: Fruit Vegetables Legumes (beans) Whole grains (rice, quinoa) Nuts Fish Poultry Low intake of: Saturated fat (cream, red meat, pork) Moderate intake of: Alcohol Am J Clin Nutr 2007;86:
WHAT FOODS WEREN’T PROTECTIVE? PRUDENT DIET High intakes of: Fruit, Vegetables Legumes/ Nuts Whole grains Fish Poultry Moderate alcohol Limited saturated fat WESTERN DIET High intakes of: Red meat Processed meat Refined grains French fries Desserts & sweets High fat dairy products
DAIRY Nurses’ Health Study (121000) & Health Professional Follow-up Study (51000) 1.8x risk Honolulu Heart Program (7500 men) 2.3x risk American Cancer Society’s Cancer Prevention Study II Nutrition Cohort (57000 men, women) Up to 1.8x risk
WHAT CONSTITUTES DAIRY? Milk, butter, cheese, cream, half & half, ice cream, sour cream, cottage cheese, cream cheese, yogurt, frozen yogurt, whey protein Individuals who consume 3-6 servings of dairy per day have 60-80% greater risk of developing PD than those who rarely or never consume it.
TEA (GREEN & BLACK) Consumption of 3+ cups/ day of tea delayed motor symptom onset by 7.7 years. Kandinov B, et al. Parkinsonism Relat Disord 2009;15(1):41-6
But what if I already have the disease.? INTERVENTION STUDIES
IF YOUR BELLY IS BIGGER THAN YOUR HIPS… THIS ONE’S FOR YOU. Calorie Restriction American’s tend to: Eat too much Eat for reasons other than to nourish CR is typically defined as 10-25% fewer calories than the average Western diet.
CR CLINICAL TRIALS Rhesus monkeys (Maswood N, et al) Natl Inst Aging 30% CR x 6 mo prior to MPTP Controls Both groups showed symptoms after MPTP At 6 months: Significantly fewer symptoms in the CR group Significantly increased concentrations of GDNF Increased survival of DA neurons (not stat sig) Proc Natl Acad Sci USA 2004;101:
GOAL- CONCENTRATE NUTRIENTS Macro == calories Fat, Protein, Carbohydrate, (Alcohol) Micro: Vitamins B-vits, Vit C, Vit A, Vit D, etc. Minerals: Ca, Mg, K, I, Li, Na, Mn, etc. Accessory: Co-Q10, carnitine, cholesterol, etc.