Presentation is loading. Please wait.

Presentation is loading. Please wait.

Systematic analysis and design of hybrid processes P. T. Mitkowski, G. Jonsson, R. Gani CAPEC Department of Chemical Engineering Technical University of.

Similar presentations


Presentation on theme: "Systematic analysis and design of hybrid processes P. T. Mitkowski, G. Jonsson, R. Gani CAPEC Department of Chemical Engineering Technical University of."— Presentation transcript:

1 Systematic analysis and design of hybrid processes P. T. Mitkowski, G. Jonsson, R. Gani CAPEC Department of Chemical Engineering Technical University of Denmark

2 European Congress of Chemical Engineering – 6 2/20 Motivation Motivation & Objectives Outline Motivation Objectives Methodology Case studies Conclusion Future work Methodology Case studies Conclusion Future work…  Hybrid process is a combination of at least two processes which influence each other and the optimization of the design must take into account this interdependency.

3 European Congress of Chemical Engineering – 6 3/20 Motivation Objectives Methodology Case studies Conclusion Future work  Hybrid processes are finding increasing use in pharmaceutical and biochemical manufacturing providing better alternatives (sometimes only alternatives) in cases where: reaction(s) kinetically or equilibrium controlled - low process yield difficult separation task - low driving force  Current design/analysis techniques are largely experiment-based, therefore, there is a potential for reducing time & costs for process development through systematic computer-aided techniques

4 European Congress of Chemical Engineering – 6 4/20 Objectives Needs & Issues  Algorithm for design-selection of processes that may be considered in the hybrid process (systems integration)  Generic model of the hybrid process through a computer aided modelling tool (modelling)  Databases of solvents, membranes, reactions and chemicals (use of available knowledge)  Case studies for validation of models, methods & tools (validation) Introduction Objectives Methodology Case studies Conclusion Future work Develop systematic computer aided methods & tools for design & analysis of a wide range of hybrid processes

5 European Congress of Chemical Engineering – 6 5/20 Methodology: Design Algorithm Introduction Objectives Methodology Case studies Conclusion Future work

6 European Congress of Chemical Engineering – 6 6/20 Methodology: Generic Model Introduction Objectives Methodology Case studies Conclusion Future work

7 European Congress of Chemical Engineering – 6 7/20 Case study: Reaction - Separation Introduction Objectives Methodology Case studies Conclusion Future work Step 1a: Esterification of cetyl oleate over Novozym 435 (Canadia anatarctica on acrylic resin) [1]. [1] T. Garcia, A.Coteron, J.Aracil,,Chem. Eng. Science 55,(2000), Step 2: Increase productivity of cetyl oleate by removing of water. X > 80 mol%. Step 1b: Solvent free system Step 3: Pervaporation with hydrophilic polymeric membranes to remove water

8 European Congress of Chemical Engineering – 6 8/20 Case study: Model Step 4: Hybrid process model Process 1: Reaction Process 2: Pervaporation m cat Introduction Objectives Methodology Case studies Conclusion Future work

9 European Congress of Chemical Engineering – 6 9/20  Constitutive equations: where :  Mol balance: Case study: Model DAE model: 4 ODEs and AEs 52 ;No. of variables: Modified UNIFAC (Lyngby) Introduction Objectives Methodology Case studies Conclusion Future work ICAS - MoT

10 European Congress of Chemical Engineering – 6 10/20 Step 4: Feasible design: Hybrid process polyvinyl alcohol membrane (PERVAP1001, GFT) A m = m 2 t batch = 5h t switch = 0h V = 0.6 dm 3 IC Equimolar C w in = 0.005mol/dm 3 Case study Am Am Introduction Objectives Methodology Case studies Conclusion Future work [min]

11 European Congress of Chemical Engineering – 6 11/20 Case study Step 4: Influence of addition of the catalyst on the batch time Introduction Objectives Methodology Case studies Conclusion Future work

12 European Congress of Chemical Engineering – 6 12/20 Case study Step 4: Influence of t switch at overall process performance in t batch = 5h 25w% Introduction Objectives Methodology Case studies Conclusion Future work

13 European Congress of Chemical Engineering – 6 13/20 Introduction Objectives Methodology Case studies Conclusion Future work Case study: Conclusion Batch reaction combined with pervaporation give promising results. Process conditions: – Amount of catalyst increase up to 30 w% – Start coupled operation within first hour – PERVAP1001, GFT

14 European Congress of Chemical Engineering – 6 14/20 Introduction Objectives Methodology Case studies Conclusion Future work Case study: Separation-Separation Step 1a: Separation of equimolar mixture of acetic acid (HAc) and water (100 kmol/hr) Experimental VLE data fitted to Mod. UNIFAC (Lyngby) Step 2: Two streams with a purity of 99.5 mol% of HAc and water Step 3: Distillation + Pervaporation with hydrophilic polymeric membrane ICAS - TML

15 European Congress of Chemical Engineering – 6 15/20 Introduction Objectives Methodology Case studies Conclusion Future work Case study: Separation-Separation Step 4: Identification of sequence of processes - Driving Force approach mol% H2O80mol% H2O 99.5 mol%HAc 99.5 mol% H2O 99.5 mol% HAc 100 kmol/hr

16 European Congress of Chemical Engineering – 6 16/20 Introduction Objectives Methodology Case studies Conclusion Future work Case study: Separation-Separation Step 4: Feasible design: Heat requirement in terms of membrane module characteristic selectivity cut  = 50  = 2.25 ICAS - MoT ICAS - Sim

17 European Congress of Chemical Engineering – 6 17/20 Introduction Objectives Methodology Case studies Conclusion Future work Case study: Conclusion Distillation combined with pervaporation gives process improvment Distillation followed by pervaporation – required high selective membrane – possible doped pollyaniline membrane Distillation with side pervaporation – can give improvment even with low selective membrane

18 European Congress of Chemical Engineering – 6 18/20 Conclusions  Systematic computer-aided methods and tools for hybrid process analysis & design has been developed and has been presented along with two case studies  The main difficulty is the availability of data and property models  Computer aided tools help to reduce time and resources needed for hybrid process development  Identifies a small set of alternatives where the experimental effort might be concentrated on Introduction Objectives Methodology Case studies Conclusions Future work

19 European Congress of Chemical Engineering – 6 19/20 Future work Introduction Objectives Methodology Case studies Conclusion Future work Investigation of other hybrid processes - 4 case studies done Further development of membrane database

20 European Congress of Chemical Engineering – 6 20/20 Thank you for your attention ! Questions are welcome ! Supervisors: Prof. G. Jonsson, Prof. R. Gani PRISM - 6th Framework EU project CAPEC co-workers Acknowledgement:


Download ppt "Systematic analysis and design of hybrid processes P. T. Mitkowski, G. Jonsson, R. Gani CAPEC Department of Chemical Engineering Technical University of."

Similar presentations


Ads by Google