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IgGIgDIgEIgAIgM Bone marrow gives rise to B cells. Mature B cells migrate to lymphoid organs. A mature B cells recognizes epitopes. Clonal Selection.

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Presentation on theme: "IgGIgDIgEIgAIgM Bone marrow gives rise to B cells. Mature B cells migrate to lymphoid organs. A mature B cells recognizes epitopes. Clonal Selection."— Presentation transcript:

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2 IgGIgDIgEIgAIgM

3 Bone marrow gives rise to B cells. Mature B cells migrate to lymphoid organs. A mature B cells recognizes epitopes. Clonal Selection

4 Hallmarks of the Immune Response Self/Non-self Discrimination Memory Specificity

5 A. Self/non-self discrimination - One characteristic feature of the specific immune system is that it normally distinguishes between self and non-self and only reacts against non-self. B. Memory - A second feature of the specific immune response is that it demonstrates memory. The immune system "remembers" if it has seen an antigen before and it reacts to secondary exposures to an antigen in a manner different than after a primary exposure. Generally only an exposure to the same antigen will illicit this memory response. C. Specificity - A third characteristic feature of the specific immune system is that there is a high degree of specificity in its reactions. A response to a particular antigen is specific for that antigen or a few closely related antigens

6 T-independent Antigens Figure B cell

7 Self-tolerance Body doesn't make Ab against self Clonal deletion –The process of destroying B and T cells that react to self antigens

8 T-Dependent Antigens Figure 17.16

9 Clonal Selection

10 Cellular Events in 1 o Response to T-dependent Ags Lag –Clonal selection Log –IgM –Class switching Stationary Decline Memory Cell Pool IgM Memory Cells IgG 1 o Ag

11 Cellular Events in 2 o Response to T-dependent Ags Lag phase –Virgin cells –Memory cells Log phase –Pool size –IgG, IgA or IgE Stationary Decline –Sustained production IgM Memory Cells IgG Memory Cells Memory Pool Virgin B cell

12 Memory T cells Th Memory Cells Th Memory Cells Memory Pool Virgin cell T Cells –Virgin cells –Memory cells Th cells –Cytokines Long Term Memory

13 Animation of cell selection

14 TORTORA FUNKE CASE Immunoglobulin Genetics

15 IgGIgDIgEIgAIgM

16 How many types of Abs??? 100 Millions 100,000,000 = 10 8

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18 Immunoglobulin Genetics History Same C region could associate with many V regions –IgG Ab with different specificities Same V region could associate with many C regions –Same idiotype on IgG and IgM Ab V and C regions coded for by separate genes

19 Light Chain Gene Families Germ line gene organization J 1 C 1 E J 2 C 2 E J 3 C 3 E J 4 C 4 E P L V 1 P L V n P L V 2 Lambda light chain genes; n=30 P L V 1 P L V n P L V 2 J 2J 3J 5 C E J 1J 4 Kappa light chain genes; n=300

20 Light Chain Gene Families Gene rearrangement and expression L V 1 L V n L V 2 J 2J 3J 5 C J 1J 4 DNA PPP E P P E L V 1 L J 5 C V 2J 4 DNA DNA Rearrangement VC J V C Protein Transport to ER Protein Translation C L V J E L V CJ RNA Transcription Primary transcript C L V J RNA Processing RNA mRNA


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