17 11-17 Figure 11.6 Other proteins such as HU and IHF also bind. This causes the region to wrap around the DnaA proteins and separates the AT-rich regionDNA replication is initiated by the binding of DnaA proteins to the DnaA box sequencesThis binding stimulates the cooperative binding of an additional 20 to 40 DnaA proteins to form a large complex11-17
18 Travels along the DNA in the 5’ to 3’ direction Figure 11.6Composed of six subunitsTravels along the DNA in the 5’ to 3’ directionUses energy from ATPBidirectional replication11-18
23 11-25 Figure 11.9 Unusual features of DNA polymerase function DNA polymerases cannot initiate DNA synthesisProblem is overcome by the RNA primers synthesized by primaseProblem is overcome by synthesizing the 3’ to 5’ strands in small fragmentsDNA polymerases can attach nucleotides only in the 5’ to 3’ directionUnusual features of DNA polymerase functionFigure 11.911-25
64 The binding-polymerization-translocation cycle can occurs many times Step 1 = BindingThe binding-polymerization-translocation cycle can occurs many timesStep 2 = PolymerizationThis greatly lengthens one of the strandsStep 3 = TranslocationThe complementarystrand is made by primase, DNA polymerase and ligaseFigure 11.25RNA primer11-80
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