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Pharmacoinformatics Remedia, s.r.o Lecture 2 Mgr. Zdeněk Kučera, Ph.D. kucera.xf.cz.

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Presentation on theme: "Pharmacoinformatics Remedia, s.r.o Lecture 2 Mgr. Zdeněk Kučera, Ph.D. kucera.xf.cz."— Presentation transcript:

1 Pharmacoinformatics Remedia, s.r.o Lecture 2 Mgr. Zdeněk Kučera, Ph.D. kucera.xf.cz

2 Přednáška 1 definitions – data, information, fact, knowledge informatics, medical informatics, pharmacoinformatics literary information sources – novelty (prim., sec., terc.), frequency of publication (periodical – ISSN, impact factor; non-periodical – ISBN), accessibility (published, grey literature, comercial literature, non-published) „factographic databases“ – MV-AISLP, Micromedex

3 Přednáška 2 bibliographic databases World: –full-texts dtb –compendia –other information sources Czech Republic: Journals, books, libraries, catalogues; internet –appraisal of information on the internet –search engines –e-books –www – practical addresses

4 bibliographic databases Secondary information sources – links to the primary sources Just information about article – where to find (and abstract/extract) General structure: Title, author, address and contacts to the author (e-mail), source – name of the journal, volume, issue, page; key words, abstract – signal what is the article about, –NO FULL-TEXT! (Sometimes link to the full-text’s www) Bibliographia Medica Čechoslovaca –http://www.nlk.cz/nlkcz/ - katalogy a dtb.http://www.nlk.cz/nlkcz/ Medline (Pubmed) – www.pubmed.com Embase – bi.cuni.cz IPA – International Pharmaceutical Abstracts Web of Knowledge – bi.cuni.cz

5 bibliographic databases – typical structure

6 Bibliographic databases BMČ – Bibliografia Medica Čechoslovaca –from 1977 –86660 records (5.2003) –no abstract –Czech journals, collections etc. + Czech authors „in the world literature“ –key words – MeSH!

7 bibliographic databases Medline – www.pubmed.com - free,www.pubmed.com –tutorial - http://www.nlm.nih.gov/bsd/pubmed_tutorial/m1001.html, –4800 journals, 15 mil. records, 86 % English, 76 % with abstracts – MeSH – dictionary of key words, synonyms –„linkout“ – link to fulltexts –part of Entrez system – National Library of Medicine – BethesdaNational Library of Medicine –limits, journal database, –batch citation matches–you know citation –Clinical queries – search filters –„loattrfree full text“ [Filter]

8 Medline - results

9 bibliographic databases Embase –Elsevier Science - publisher –more european journals –cca 5000 journals, from 1974 –NOT free, for UK students – see http://bi.cuni.cz (via lfhk!) http://bi.cuni.cz –Thesaurus – EMTREE – key words – more „clinical“ tree

10 bibliographic databases ISI Web of Knowledge –Web of Science – citations with abstracts, 3500 journals –Current Contents – recent publications –Journal Citations Reports – Impact factor –more... multi-disciplines orientation !!! Information how many times was article cited by other articles !!! => impact factor

11 ISI Web of knowledge...

12 Full-text databases Multi-publisher collections –Proquest – http://proquest.umi.com/pqdwebhttp://proquest.umi.com/pqdweb –EBSCO - http://web34.epnet.com/selectdb.asp?tb=1&_ug=sid+ 3D5F7B72%2DEC06%2D4F2B%2DA51D%2DCFE2 77DD7E53%40sessionmgr4+9557&ft=1 http://web34.epnet.com/selectdb.asp?tb=1&_ug=sid+ 3D5F7B72%2DEC06%2D4F2B%2DA51D%2DCFE2 77DD7E53%40sessionmgr4+9557&ft=1 1 publisher – see bi.cuni.cz –Elsevier –Blackwell –Wiley –Springer –…

13 Compendia Martindale – The extrapharmacopoea –http://www.pharmpress.com National compendias –BNF – UK – www.bnf.orgwww.bnf.org –Rote, Gelbe Liste – Germany –AHFS DI, USP DI, PDR – USA http://www.micromedex.com/products/uspdi/uspdi_factsheet. pdf, http://www.usp.org/products/USPDIReference.html, http://www.medlineplus.com/http://www.micromedex.com/products/uspdi/uspdi_factsheet. pdfhttp://www.usp.org/products/USPDIReference.html http://www.medlineplus.com/ http://www.ashp.org/ahfs/ –ARZNEIMITTEL-KOMPENDIUM DER SCHWEIZ - SUI

14 Other books Index Nominum –5300 substances –12 800 synonyms –41 800 brand names –chemical formulas Meyler’s Side effects Stockleys Drug Interactions Drugs In Pregnancy and Lactation Merck Manuals http://www.merck.com/pubs/http://www.merck.com/pubs/

15 Journals - world „Impact five journals“ – prim. or sec. infosources –JAMA + Archives – pubs.ama-assn.org The Journal od the American Medical Associationpubs.ama-assn.org –Lancet – www.thelancet.comwww.thelancet.com –NEJM – www.nejm.com New England Journal of Medicinewww.nejm.com –BMJ – www.bmj.comwww.bmj.com –Annals of Internal Medicine – www.annals.orgwww.annals.org Drugs – Adis www.adis.comwww.adis.com –Drugs, CNS Drugs,... Reviews Perspectives – Expert Opinion on Investigational Drugs, Current Opinion in Investigational drugs, Trends in … --------------- Useful functions: TOC – table of contents to e-mail Archive of issues

16 Journals – foreign – non-profit International Society of Drug Bulletins - Members http://66.71.191.169/isdbweb/pag/index.php http://66.71.191.169/isdbweb/pag/index.php –Australian Prescriber www.australianprescriber.com www.australianprescriber.com –La revue Prescrire www.prescrire.orgwww.prescrire.org

17 Compendia – Czech Rep. Remedia Compendium – www.remedia.cz Pharmindex systemu – Kompendium, Brevíř – www.medimedia.cz Medistránky - http://www.medistranky.cz/http://www.medistranky.cz/

18 Czech periodicals – types A Medical journals - +- 70... ČLS JEP –http://www.clsjep.cz/nts/casopisy.asphttp://www.clsjep.cz/nts/casopisy.asp –primary literary sources – research results –Reviews, editorials –Vnitřní lékařství –Praktický lékař –Česká a slovenská farmacie! etc...

19 Czech periodicals – types B „Publishing houses“ –Medical Tribune Group – principle – joint-venture with global publishers www.medical-tribune.czwww.medical-tribune.cz Medical Tribune – „newspapers“ – 1* 2 weeks XY po promoci – eg. Medicína po promoci –selection from Postgraduate Medicine, American Family Physician, Deutsche Medizinische Wochenschrift“ –Praha Communications – the same Czech JAMA http://www.prahacom.com/fr.php3?co=products.php3 http://www.prahacom.com/fr.php3?co=products.php3

20 Czech periodicals – types C Publishers – public –MF Dnes – Zdravotnické noviny www.zdn.czwww.zdn.cz Publishers – „Czech reviews“ –Solen - www.solen.cz – full-texts!www.solen.cz Klinická farmakologie a farmacie (http://www.klinickafarmakologie.cz/ )http://www.klinickafarmakologie.cz/ „XY“ pro praxi – př. Interní medicína pro praxi Praktické lékárenství apod. –Tigis – www.tigis.cz – full-textswww.tigis.cz Psychiatrie Bolest Etc.

21 Czech periodicals – types D Drug specialists... –Remedia s.r.o www.remedia.czwww.remedia.cz Remedia, full-texts – 1st year later –Farmakon Press s.r.o www.farmakoterapie.czwww.farmakoterapie.cz Farmakoterapie 1st year, fulltext –Edukapharm s.r.o Farminews – www.edukafarm.czwww.edukafarm.cz

22 Czech periodicals – types E Educational projects of farmaceutical companies Advantage – full texty –PACE News – www.pace.cz - Apotexwww.pace.cz –Kapitoly z kardiologie – www.kapitoly.cz - BMSwww.kapitoly.cz

23 Czech periodicals – types F Professional organisations: –Česká lékárnická komora – Časopis českých lékárníků www.lekarnici.czwww.lekarnici.cz –Česká lékařská komora (Czech Medical Chamber)– Tempus medicorum www.lkcr.czwww.lkcr.cz Institutions: –SÚKL www.sukl.czwww.sukl.cz „věstník“ = bulletin !Farmakoterapeutické informace! – non-profit CR –Ministry of Health www.mzcr.czwww.mzcr.cz bulletin –Ministerstvo www.mvcr.czwww.mvcr.cz Collection of Laws

24 Czech e-books.pdf format: –Solutio – www.medon-solutio.czwww.medon-solutio.cz –PACE publications www.pace.czwww.pace.cz

25 Monographies HK – knihkupectví u ČSA, Fakultní nemocnice, Fakulty Praha – Lipová 6 – Wimmer, Academia – Václavské nám., Celetná – prodejna skript UK INTERNET - www.kompas.cz, www.vltava.cz, www.amazon.com, publishers – Springer, HighWirePress, Oxford University Press, Elsevier, Wiley, Blackwell etc…www.kompas.czwww.vltava.cz www.amazon.com Libraries

26 Knihovny National medical library –Cataloques: Cataloques of all medical books and journals in the CR – www.nlk.cz – LSS, LBS www.nlk.cz Cataloque of NLK – NML – books, journals in national library BMC – Bibliographia Medica Čechoslovaca –Electronical sources – ULTRA ACCESS! –Electronical circulation record – how to: http://www.nlk.cz/nlkcz/uvod.php?id_m=67 (in czech) http://www.nlk.cz/nlkcz/uvod.php?id_m=67 –Possibility of search in English

27 Knihovny Národní knihovna ČR = National library CR – Klementinum, www.nkp.czwww.nkp.cz bi.cuni.cz/ –„Jednotná informační brána“ –„Souhrný katalog knihoven UK“ Státní technická knihovna = State technical library – Ultra Access – medical dtb as well! http://ezproxy.stk.cz:5556/login?OK=Souhlas%E Dm http://ezproxy.stk.cz:5556/login?OK=Souhlas%E Dm Information Centres in IKEM, Motol, LF HK – (kde?), FaF atd...

28 Internet 1969 – from Arpanet – see wikipedia.org –www –e-mail – mailing groups –ftp –Etc.

29 WWW – Critical appraisal and evaluation criteria Freiburgh criteria: http://www.imbi.uni-freiburg.de/medinf/gmdsqc/e.htm HON criteria: http://www.hon.ch/HONcode/Conduct.html Many related links on: http://www.vuw.ac.nz/staff/alastair_smith/evaln/evaln.htm

30 Simple criteria Presentation – speed of appearance, links, design Navigation – steps, „back“ possibility, highliting of links, site map Function – multilanguage, search, accessibility, „text“ form without graphics Credibility – contacts, up-dates, date, author

31 More complicated… Credibility: includes the source, currency, relevance/utility, and editorial review process for the information Content: must be accurate and complete, and an appropriate disclaimer provided. Disclosure: includes informing the user of the purpose of the site, as well as any profiling or collection of information associated with using the site. Links: evaluated according to selection, architecture, content, and back linkages. Design: encompasses accessibility, logical organization (navigability), and internal search capability. Interactivity: includes feedback mechanisms and means for exchange of information among users. Caveats: clarification of whether site function is to market products and services or is a primary information content provider.

32 Logos – medicinal www Hardin MD – see e.g. http://www.sugarlessdelite.com/http://www.sugarlessdelite.com/ Health On the Net Foundation – see e.g. www.pubmed help, http://www.australianprescriber.com/, www.zdn.cz etc. www.pubmedhttp://www.australianprescriber.com/ www.zdn.cz

33 Internet – encyclopedias, vocabularies www.wikipedia.org – Wikipedia – freewww.wikipedia.org www.britannica.com – partially freewww.britannica.com http://wordnet.princeton.edu/ - vocabularyhttp://wordnet.princeton.edu/ ---- medicine: http://www.nlm.nih.gov/medlineplus/ - MedlinePlushttp://www.nlm.nih.gov/medlineplus/ www.maxdorf.cz – medical vocabularywww.maxdorf.cz

34 Hardin General Specializované Internet – search engines How to search: http://www.vuw.ac.nz/staff/alastair_smith/searching/ Just links to other sites! Directories – „trees“ - browsing Search engines – crawler, browser – databases of „words“

35 Directory - www.dmoz.orgwww.dmoz.org

36 Search engine - www.google.com

37 Search Engines - statistics

38 Scientific search engines: Scirus www.scirus.com, Google scholar.google.comwww.scirus.com Medicinal search engines: HON http://www.hon.chhttp://www.hon.ch Specialized search engines

39 Medicinal directories Hardin: http://www.lib.uiowa.edu/hardin/md/http://www.lib.uiowa.edu/hardin/md/

40 Medical servers - World MEDSCAPE - www.medscape.com – after registration (free) fulltexts, articleswww.medscape.com UpToDate – www.uptodate.com – not for freewww.uptodate.com RxList – www.rxlist.com – „all“ prescription drugswww.rxlist.com

41 Others - World www.perinatology.com – pregnancywww.perinatology.com www.freemedicaljournals.com – free journalswww.freemedicaljournals.com www.freebooks4doctors.com – dtto bookswww.freebooks4doctors.com Pharmaceutical Resources on the Net – http://www.hsl.wisc.edu/pharmacy/pharmr es.cfm http://www.hsl.wisc.edu/pharmacy/pharmr es.cfm

42 Servers - CR www.medicina.cz www.mediclub.cz www.zdravcentra.cz – for GP from ZENTIVAwww.zdravcentra.cz –Many functions – drug information centres –List of free journals –Adress book of GP´s, pharmacies –Many articles www.ordinace.cz – Pears Health Cyber – for publicwww.ordinace.cz www.safebryo.cz – pregnancywww.safebryo.cz

43 If it is moving, we have to end the lecture – you are critically tired! Thank you for your attention


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