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him-3 High Incident Males (increased X chromosome loss) By Chang Lee
him-3 encodes a homolog of the S. cerevisiae HOP1 protein which is required for the formation of the synaptonemal complex during meiosis Predicted by GeneFinder Washington University, St. Louis MO.
How large? 1.2 kb mRNA sequence : 1113 bp 4 exons The gene contains 3 introns
What chromosome is the gene on? chromosome IV positions 6,977,403 to 6,978,631
There are available cDNA CK575867, EB994223, OSTF002C4_1 EC023874 CK589379 AF172351 EST data
Mutants Mutant e1147 gk149 vv6 e1256 me80 Its phenotype is embryonic lethal, partial, high incidence of males, increased X chromosome loss
The final gene product is a HOP1- like protein him-3 encodes a homolog of the S. cerevisiae HOP1 protein
homologs in other species C. Briggsae 4.5e-66 C remanei 1.4e-27 C Elegans 2e-22 M Musculus 3.6e-12 H sapiens 4.8-12
structural components The DNA-binding HORMA motif is seen in the product of this geneDNA-binding HORMA The HORMA (for Hop1p, Rev7p and MAD2) domain has been suggested
molecular function HIM-3 may be part of a mechanistic link that exists between the early prophase events of synapsis and recombination, and later events such as segregation
references http://www.genesdev.org/cgi/search?session_query_re f=rbs.queryref_1209325456816&COLLECTIONS=hw1& JC=genesdev&FULLTEXT=%28size+AND+of+AND+him - 3+AND+gene%29&FULLTEXTFIELD=lemcontent&RESO URCETYPE=HWCIT&ABSTRACTFIELD=lemhwcompabstr act&TITLEFIELD=lemhwcomptitlehttp://www.genesdev.org/cgi/search?session_query_re f=rbs.queryref_1209325456816&COLLECTIONS=hw1& JC=genesdev&FULLTEXT=%28size+AND+of+AND+him - 3+AND+gene%29&FULLTEXTFIELD=lemcontent&RESO URCETYPE=HWCIT&ABSTRACTFIELD=lemhwcompabstr act&TITLEFIELD=lemhwcomptitle http://www.wormbase.org/db/gene/gene?name=WBGe ne00001862;class=Genehttp://www.wormbase.org/db/gene/gene?name=WBGe ne00001862;class=Gene http://www.ncbi.nlm.nih.gov/IEB/Research/Acembly/a v.cgi?db=worm&q=4H743http://www.ncbi.nlm.nih.gov/IEB/Research/Acembly/a v.cgi?db=worm&q=4H743 http://linkinghub.elsevier.com/retrieve/pii/S096098220 4002179http://linkinghub.elsevier.com/retrieve/pii/S096098220 4002179 http://www.sanger.ac.uk/cgi-bin/Pfam/getacc?PF02301
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