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Genes on Chromosome 1 Breast cancer; 1p36Breast cancer; 1p36 Autosomal DeafnessAutosomal Deafness Susceptibility to Acute Leukemia; 1q21Susceptibility.

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Presentation on theme: "Genes on Chromosome 1 Breast cancer; 1p36Breast cancer; 1p36 Autosomal DeafnessAutosomal Deafness Susceptibility to Acute Leukemia; 1q21Susceptibility."— Presentation transcript:

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2 Genes on Chromosome 1 Breast cancer; 1p36Breast cancer; 1p36 Autosomal DeafnessAutosomal Deafness Susceptibility to Acute Leukemia; 1q21Susceptibility to Acute Leukemia; 1q21 Cataracts; 1p36.13Cataracts; 1p36.13 Alzheimer's; 1q21 & 1q25Alzheimer's; 1q21 & 1q25 Parkinson Disease; 1p36Parkinson Disease; 1p36 Epilepsy; 1q21Epilepsy; 1q21

3 Base sequence of CYP4A11 1 gggtggtcag agagaggtag gggcactcag agatccagca ggtgctgcac catgagtgtc 61 tctgtgctga gccccagcag actcctgggt gatgtctctg gaatcctcca agcggcctcc 121 ctgctcattc tgcttctgct gctgatcaag gcagttcagc tctacctgca caggcagtgg 181 ctgctcaaag ccctccagca gttcccgtgc cctccctccc actggctctt cgggcacatc 241 caggagctcc aacaggacca ggagctacaa cggattcaga aatgggtgga gacattccca 301 agtgcctgtc ctcattggct atggggaggc aaagttcgtg tccagctcta tgaccctgac 361 tatatgaagg tgattctggg gagatcagac ccgaaatccc atggttccta cagattcctg 421 gctccatgga ttgggtacgg cttgctcctg ttgaatgggc agacatggtt ccagcatcga 481 cggatgctga ccccagcctt ccactatgac atcctgaagc cctatgtggg gctcatggca 541 gactctgtac gagtgatgct ggacaaatgg gaagagctcc ttggccagga ttcccctctg 601 gaggtctttc agcacgtctc cttgatgacc ctggacacca tcatgaagtg tgccttcagc 661 catcagggca gcatccaggt ggacaggaat tctcagtcct acatacaggc cattagtgac 721 ctgaacaacc tggttttttc ccgtgtgagg aatgcctttc accagaatga caccatctac 781 agcctgacct ctgctggccg ctggacacac cgcgcctgcc agctggccca tcagcacaca 841 gaccaagtga tccaactgag gaaggctcaa ctacagaagg agggggagct ggagaagatc 901 aagaggaaga ggcatttgga ttttctggat atcctcctct tggccaaaat ggagaatggg 961 agcatcttgt cagacaagga cctccgtgct gaggtggaca cgttcatgtt tgagggccac 1021 gacaccacag ccagtgggat ctcctggatc ctctatgctc tggccacaca ccccaagcat 1081 caggagaggt gccgggagga gatccacagc ctcctgggtg atggagcctc catcacctgg 1141 aaccacctgg accagatgcc ctacaccacc atgtgcatta aggaggcact gaggctctac 1201 ccaccggtgc caggcattgg cagagagctc agcactcccg tcaccttccc tgatgggcgc 1261 tccttgccca aaggtatcat ggtcctcctc tccatttatg gccttcacca caacccaaaa 1321 gtgtggccca acccagaggt gtttgaccct ttccgttttg caccgggttc tgctcaacac 1381 agccacgctt tcctgccctt ctcaggagga tcaaggaact gcatcgggaa acaatttgcc 1441 atgaacgagc tgaaggtggc cacggccctg accctgctcc gctttgagct gctgcctgat 1501 cccaccagga tccccatccc cattgcacga cttgtgttga aatccaaaaa tggaatccac 1561 ctgcgtctca ggaggctccc taacccttgt gaagacaagg accagctttg agggcctcca 1621 cctgccgtcc tgtcttcctg acccccgctt ctgtcccctt cctgtctgcc catatcctgt 1681 tttctgtctg cccaccttcc cttcttccca cctgcctgct gtcccccagt ctgcctgccc 1741 ttctctctct cacctttctc caggctccct acctgcttgt ctacctgtct cctacccacc 1801 tgtatctctt gttgggagaa aagctgagtg ttgggagaag ctgaggccga gcttgcatgt 1861 ctgacataat gtaaaagagt cttggatcat gtccaggatc cagggtctaa aaccccttgt 1921 ggcctttgga acaccaagct ctgtgctgaa gggtggaagg ctaccctgac gcaccataat 1981 ctaagcccgg ggcataaaac ccctcgtggc ttggatagaa tccagggctc gtggctctgg 2041 aatgtgtctg aacttgctgc ctcctcgctc cttgctctcc caggatcaat tgtatcttga 2101 gttaaaagaa cctgctctcc attatctcaa gtagcagagc agatgctaaa ccgtcacagc 2161 tgtaaatcat gtgcttaatg caacatgccc tttcgacccc cacattctca ccacctgttt 2221 ctttgtttga tcaccaataa ataatctgca cttccagagc tcggggcctt cacagcctcc 2281 atccttagct ttggcgccct ggacccactt tctctctcaa actgtctttt ctcactgctt 2341 tgactctgcc ggactttgtc acccccacga cctggtgttg ggtctgaaca ccccaacatc 2401 cctgaatctc cacccacctc ccaaactcct gcctgccctc cagactgtct gcccatacac 2461 ctgtctcctt cttcctgcct gcttgtctgt tcctatatta gtttcctatt actgctgtaa 2521 taaactatca caatctcagt gattttaaat aa (Cytochrome)

4 Linked Genes Epilepsy, Leukemia, Alzheimers (1q21) Epilepsy, Leukemia, Alzheimers (1q21) Breast Cancer, Parkinson Disease (1p36) Breast Cancer, Parkinson Disease (1p36) Known/Suspected Mutations: frequently deleted 1p36.3 regionfrequently deleted 1p36.3 region

5 263 million base pairs263 million base pairs Approx genes found on chromosome 1 Approx genes found on chromosome 1 Approx. 99% has been sequenced Approx. 99% has been sequenced


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