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Cells August 28 th, 2007. Cell History Robert Hooke (1635- 1703) Robert Hooke (1635- 1703) Viewed slices of cork under a crude compound microscope Viewed.

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Presentation on theme: "Cells August 28 th, 2007. Cell History Robert Hooke (1635- 1703) Robert Hooke (1635- 1703) Viewed slices of cork under a crude compound microscope Viewed."— Presentation transcript:

1 Cells August 28 th, 2007

2 Cell History Robert Hooke ( ) Robert Hooke ( ) Viewed slices of cork under a crude compound microscope Viewed slices of cork under a crude compound microscope He saw boxes which reminded him of cells that monks lived in He saw boxes which reminded him of cells that monks lived in –Hence the name cell

3 Cell History Anton van Leeuwenhoek ( ) Anton van Leeuwenhoek ( ) Designed an early microscope Designed an early microscope First to see living organisms in a drop of water First to see living organisms in a drop of water

4 Cell History Robert Brown ( ) Robert Brown ( ) Used special stains and dye to view nucleus Used special stains and dye to view nucleus

5 Cell History Mathias Schleiden, botanist ( ) Theodor Schwann, zoologist, ( ) Rudolph Virchow, physician ( )

6 Cell Theory Schleiden, Schwann and Virchow each contributed to the cell theory ( ): Schleiden, Schwann and Virchow each contributed to the cell theory ( ): 1. Cells are the basic unit of structure and function of all living things 2. All living things are composed of one or more cells 3. New cells are produced from existing cells

7 Cell Types Prokaryotic Prokaryotic –First appear in fossil record 3.5 BYA –No membrane bound organelles –No Nucleus –Bacteria Eukaryotic Eukaryotic –Evolved 1.5 BYA –Have membrane bound organelles –Have Nucleus –Protists, fungi, animals, plants

8 Cell Structures Cell Membrane Cell Membrane (AKA: Plasma Membrane) –Selectively permeable Regulates what goes in and out Regulates what goes in and out –Flexible –Provides protection and support –Made of a lipid bilayer

9 Phospholipids Fatty acid tails are non-polar Fatty acid tails are non-polar Heads are polar Heads are polar Tails dont want to be near water because water is polar so they are inside the bilayer. Tails dont want to be near water because water is polar so they are inside the bilayer.

10 Cell Membrane Lipid Bilayer Lipid Bilayer Outside of cell Inside of cell (cytoplasm) Cell membrane Proteins Protein channel Lipid bilayer Carbohydrate chains

11 Cellular Transportation The cell membrane is selectively permeable and allows some particles come into the cell and keeps some of them out.

12 2 Types of Transportation Passive Transport * The cell does not use any energy. * The cell does not use any energy. * Materials flow down the concentration gradient from High concentration to low concentration Active Transport * Requires that the cell use energy. * Movement of solutes against a concentration gradient from Low concentration to High concentration.

13 The 3 most common types of Passive Transport: 1. Diffusion 2. Osmosis 3. Facilitated Diffusion

14 Diffusion The overall direction of the movement is referred to as the Gradient. The overall direction of the movement is referred to as the Gradient. In diffusion molecules usually move down the concentration gradient..... flow from high concentration to low concentration. In diffusion molecules usually move down the concentration gradient..... flow from high concentration to low concentration. A state of equilibrium is reached where molecules are uniformly distributed but continue to move randomly. A state of equilibrium is reached where molecules are uniformly distributed but continue to move randomly.

15 Simple Diffusion High ConcentrationLow Concentration Direction of Diffusion Molecules Selectively Permeable Membrane

16 Osmosis The diffusion of WATER across a selectively permeable membrane is called OSMOSIS. The diffusion of WATER across a selectively permeable membrane is called OSMOSIS. Osmotic environments are classified by the concentration of the solutes in the solution. Osmotic environments are classified by the concentration of the solutes in the solution.

17 Osmotic environments are classified as: 1. Isotonic 1. Isotonic 2. Hypertonic 2. Hypertonic 3. Hypotonic 3. Hypotonic

18 Isotonic Environment In an Isotonic solution, the concentration of solutes outside and inside the cell are equal. In an Isotonic solution, the concentration of solutes outside and inside the cell are equal. Water is moving in and out at an equal rate. Water is moving in and out at an equal rate. 95% Water 5% Solutes 95% Water 5% Solutes

19 Hypertonic Environment Concentration of solutes is greater outside the cell than inside the cell. Concentration of solutes is greater outside the cell than inside the cell. Water will move outside the cell… the cell will shrink and die. Water will move outside the cell… the cell will shrink and die. 95% Water 5% solute 97% Water 3% solute

20 Hypotonic Environment Concentration of solutes is greater inside the cell than outside the cell. Concentration of solutes is greater inside the cell than outside the cell. Water will move inside the cell… the cell will swell, or burst, and die. Water will move inside the cell… the cell will swell, or burst, and die. 97% Water 3% solute 95% Water 5% solute

21 Facilitated Diffusion The diffusion of large particles through channel proteins in the plasma membrane. The diffusion of large particles through channel proteins in the plasma membrane. Example: Glucose moves in and out of cells through Facilitated Diffusion. Example: Glucose moves in and out of cells through Facilitated Diffusion.

22 Active Transport *Solutes flow against the concentration gradient. * The cell uses energy… usually ATP. *Requires Transport Proteins Types of Active Transport are: 1. Exocytosis 2. Endocytosis (Phagocytosis & Pinocytosis)

23 Exocytosis (exo = outside, Cyto = cell) Moving substances outside the cell Process of vesicles fusing with the plasma membrane and releasing their content to the outside of the cell.

24 Endocytosis (endo = inside, cyto = cell) The capture of substances The capture of substances outside the cell when the plasma membrane merges to engulf it.

25 Phagocytosis (phago = to eat, cyto = cell) Phagocytosis occurs when undissolved solids enter a cell. The plasma membrane wraps around the solid material and engulfs it, forming a vesicle. Phagocytic cells, such as white blood cells, attack and engulf bacteria in this manner.

26 Pinocytosis (pino = to drink, cyto = cell) Pinocytosis occurs when dissolved materials enter a cell. The plasma membrane folds inward to form a channel allowing the liquid to enter. The plasma membrane closes off the channel, encircling the liquid inside a vesicle.

27 Cell Structures The cytoplasm is a jelly-like substance that holds many other organelles such as: Endoplasmic Reticulum – transports lipids and proteins Endoplasmic Reticulum – transports lipids and proteins Ribosomes – produce proteins Ribosomes – produce proteins Golgi Apparatus – packages and delivers proteins Golgi Apparatus – packages and delivers proteins Mitochondria – Transform energy into a chemical form that can be used by the cell. Mitochondria – Transform energy into a chemical form that can be used by the cell. Lysosomes – Help with cell digestion Lysosomes – Help with cell digestion Peroxisomes – House enzymes that speed up chemical reactions. Peroxisomes – House enzymes that speed up chemical reactions.

28 Cell Structures (cont.) Microfilaments/Microtubules – form cytoskeleton to help with cell movement. Microfilaments/Microtubules – form cytoskeleton to help with cell movement. Centrosome – Contains centrioles that help during Mitosis. Centrosome – Contains centrioles that help during Mitosis. Cilia/Flagella – Cellular extensions that aid in cell movement. Cilia/Flagella – Cellular extensions that aid in cell movement. Vesicles – sacs that form to help particles come into and out of the cell. Vesicles – sacs that form to help particles come into and out of the cell.

29 Why are cells so small? Surface Area vs. Volume Surface Area vs. Volume –As a cell grows larger, the volume increases faster than the SA –A bigger cell needs more nutrients, but has relatively less SA to take in those nutrients

30 Surface Area vs. Volume Cell Size 5 cm 10 cm Surface Area (l×w×6) 150 cm cm 2 Volume (l×w×h) 125 cm cm 3 SA to Volume Ratio 150/125 = 6:5 600/1000 = 6:10

31 Cell Cycle Cells divide before growing too large Cells divide before growing too large Before dividing, cells must prepare Before dividing, cells must prepare Preparation = Interphase Preparation = Interphase –G 1 phase: Cell grows larger –S phase: Cell makes new DNA for daughter cell –G 2 phase: Cell makes new organelles for daughter cell

32 Cell Cycle

33 Chromosomes Each chromosome is replicated during the S phase Each chromosome is replicated during the S phase A replicated chromosome has two identical sister chromatids connected by a centromere A replicated chromosome has two identical sister chromatids connected by a centromereCentromere Sister Chromatids

34 Mitosis Four Stages: Four Stages: –Prophase (pro- means first) –Metaphase (meta- means middle/after) –Anaphase (ana- means apart) –Telophase (telo- means far away/end)

35 Prophase Chromatin condenses into chromosomes Chromatin condenses into chromosomes Nuclear envelope and nucleolus disintegrate Nuclear envelope and nucleolus disintegrate Centrioles migrate to opposite ends of the cell Centrioles migrate to opposite ends of the cell Spindle fibers form in foot ball shape across cell Spindle fibers form in foot ball shape across cell Chromosomes condensing

36 Prophase

37 Metaphase Chromosomes line up in the middle (equator) of the cell Chromosomes line up in the middle (equator) of the cell Spindle fibers attach to centromeres Spindle fibers attach to centromeres

38 Metaphase

39 Anaphase Sister chromatids separate Sister chromatids separate Spindle fibers shorten, pulling chromatids to opposite ends of cell Spindle fibers shorten, pulling chromatids to opposite ends of cell Animal cells begin to pinch in Animal cells begin to pinch in Plant cells begin to form cell plate in the middle Plant cells begin to form cell plate in the middle

40 Anaphase

41 Telophase Nuclear membrane built from ER around each set of chromosomes Nuclear membrane built from ER around each set of chromosomes Nucleolus reforms in each nucleus Nucleolus reforms in each nucleus Chromosomes become mass of chromatin Chromosomes become mass of chromatin

42 Telophase Two cells dividing into four

43 Cytokinesis Final division of cytoplasm resulting in two daughter cells Final division of cytoplasm resulting in two daughter cells Animals – Cell Membrane pinches together Animals – Cell Membrane pinches together Plants – Cell plate forms new Cell Membrane dividing into the daughter cells Plants – Cell plate forms new Cell Membrane dividing into the daughter cells

44 Which phases can you see? Prophase Metaphase Anaphase Telophase Interphase

45 Knowing when to divide Cyclins Cyclins –Protein that regulates the cell cycle in eukaryotes Internal regulators – tell the cell when to enter mitosis Internal regulators – tell the cell when to enter mitosis External regulators – control the rate of the cell cycle External regulators – control the rate of the cell cycle

46 Cellular Response to Injury

47 Effect of Cyclins Cytoplasm is removed from cell in mitosis Cytoplasm is injected into a second cell in G 2 phase Second cell enters mitosis

48 Cancer Cancer results when cells do not respond to cell cycle regulators Cancer results when cells do not respond to cell cycle regulators Cells grow unregulated, forming a tumor Cells grow unregulated, forming a tumor Tumor damages surrounding tissue Tumor damages surrounding tissue

49 Leukemia – Blood cancer

50 Mammary (Breast) Cancer

51 Skin Cancer


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