520th Century SCIENCEThe 20th century was the domain of the physical sciences. Incredible discoveries were made, and then converted into applications for commerce and military.How many of these chaps are you familiar with?
6Alba – GFP bunnyExpired in 2002“Transgenic art”AP Lab #6
7Human Genome Project Completed in 2003 Cost $2.7 billion Joint Genome Institute (Walnut Creek, CA)Sequenced entire human genome (DNA)Cost $2.7 billion2004, Celera (J. Craig Venter) = $300,000,000 (11%)2010, Illumina (San Diego, CA) = $14,500 (0.0005%)2013, $1,000 or less21st century = Molecular BiologyIf you do not agree, consider but one example, the sequencing of a human genome.
821st Century Therapies Gleevec – Chronic Myelogenous Leukemia 1 pill a daySprycel & TasignaIn 2010, Oncept DNA VaccineCanine Oral MelanomaTransdermal applicationJune 2010, “siRNA ‘Cure’ for Ebola?” (Geisbert et al.)May 20, 2010, first “synthetic” life form is created
92013 BiotechnologyU. Pitt group produces human heart cells from iPSCs that spontaneously beats on its ownHuman Liver tissue regrown from iPSCsSurgeons at Duke University implanted a bioengineered blood vessel into patientNetherlands researchers produced lab-grown burger from ONLY cow stem cells.
10Stanford University Newest department: Bioengineering Stanford has a $1,000,000,000 commitmentLast department added: 23 years agoComputer ScienceSilicon ValleyMITBroad Institute of MIT & Harvard (2004)Koch Institute for Integrative Cancer Research (2008)
122013 AP Biology Results Pass Rate = 88% “5”s = 10% Students = 100 There will be zero 1s or 2s this year.
13Why this class is difficult… 1. Honors Biology ≠ AP Biology-- Biology knowledge base may be deficientChapters (over 1,000 pages)3. 3 credits vs. 8 credits for college4. Significant Mathematics focus (Chi-Square Test, etc.)5. Application & Evaluation Test Questions
14Why this class not difficult… 1. Clear expectationsVocabulary & Objectives2. Information is readily available3. Course Materials sourced from 5 Biology textbooks4. Course materials are easily accessible5. Few complicated concepts
15What is a College Level Course? Student-Driven Learning“students are expected to work independently outside the class”Role of teacher is to highlight some important pointsWill NOT cover every concept in classHomework will consist of videos or readings that need to be completed before class
18Class Discussions You WILL be called on to attempt an answer I want to hear what you have to sayPlease make all questions and comments relevant to the content discussionIf your question is off topic, write it down and ask it later
20AP Biology Background Undergrad: Philosophy & Biochemistry Masters: Medical Economics & EpidemiologyHHMI (Howard Hughes Medical Institute) CohortInaugural Fellow University of FloridaAP Summer Institute (2007, 2008, 2009, & 2012)AP Fellows Grant & Stanford UniversityAP Annual Conference (2008, 2012)AP Biology Review at 2012 National Science BowlBroward County 2013 AP Biology ReviewTest Item Contributor for 2014 AP Biology Exam
22Summer Project The worksheet is due by 11:59pm on 8/23/13 toThe Online Assessments must be complete by 11:59pm on 8/23/13In Class Assessment:Biology – Wednesday (8/21/13)Chemistry – Friday (8/23/13)
23BUM Insights Nucleoid / Cell Wall present in bacterial cells? Prokaryotes?Does Golgi Body (Apparatus) contain ribosomes?Need to know the number of chromosomes, chromatids, and chromatin in each stage of mitosisWhat is the longest phase of the cell cycle?
24BUM In Class Assessment 30 Questions8 Multiple Correct (Select ALL of the following…)22 Multiple ChoiceSpread evenly between 3 topics covered in the BUMAbout ½ of the questions are applicationReview the Formative Assessment & WorksheetThink about what would happen if an organelle or molecule were to malfunction.Consider various pathologies of cell organelles, molecular properties of water, and cell cycle
25CUS Insights Polar means it can dissolve in ______ Amino acids can act as BOTH an _____ and a _____Which functional groups act like acids? Bases?Learn Polar bonds and polar molecule rulesWhich molecules exhibit Van der Waal forces?Which functional groups have a carbon double bonded to an oxygen?
26CUS In Class Assessment 26 Questions16 Multiple Choice10 Multiple CorrectScore is out of 25 (one question is effectively Xtra credit)Review the Formative Assessment & WorksheetFunctional groups are important
27Upcoming Tests 8/28/13 – First Test 10/14/13 TEST Q1-01 (15%) Covers Only Chapters 3-5Focus is on CH 5Application & Pathologies10/14/13Cumulative Test (20%)Afterschool on Monday 10/14/13110 students in Auditorium & 60 students in Media Center