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Laboratory Risk Management

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Presentation on theme: "Laboratory Risk Management"— Presentation transcript:

1 Laboratory Risk Management
Professor Michael Gillings Department of Biological Sciences Macquarie University, NSW 2109

2 My personal safety priorities
People Samples Equipment and infrastructure Safety is about understanding the risks, not about blindly following safety instructions

3 Risks to People Chemical Radiation Infectious Physical

4 Chemical Safety Chemical handling and disposal conforms with the most up to date regulations

5 Chemical risk management
Area of concern Response Knowledge Laboratory induction, supervision MSDS documentation Chemical labeling Exposure Protective clothing Fume hoods Safety showers / eyewash Disposal Segregated waste streams Treat every compound as if it were poisonous

6 Long Term: Reduce and Replace
Large volume phenol/chloroform DNA extractions Replace with small volume non-solvent kits DNA staining with ethidium bromide Replace with non-carcinogenic stains

7 Radiation Safety Radiation hazards are dealt with by induction, radiation safety officers and specialized containment

8 Radiation risk management
Area of concern Response Ultraviolet light Dedicated space / safety visors Microwaves Microwave testing Radioisotopes Dedicated radiation suite Licensing / Radiation safety officer Radiation training / exposure badges Protective shields and clothing

9 Long Term: Reduce and Replace
Significant decline in the use of radioactive materials. Replacement with non-isotopic labeling systems and detection methods.

10 Microbiological Safety
Staff and students are trained in microbiological procedures, and governed by regulations on biosafety and quarantine

11 Risks with infectious agents
Area of concern Response Pathogenic organisms Biosafety approval / blood & tissues Good microbiological practice Protective clothing Class II cabinets Zoonotic diseases Biosafety approval Animal ethics approval SOPs for animal work

12 Physical containment Area of concern Response
Quarantinable specimens Dedicated PC2 / quarantine lab Genetically modified organisms Biosafety induction & permits OGTR inspection & certification Physical containment laboratories PC2 operating rules / disposal

13 Physical risk management
Laboratories conform to strict building codes (fire ratings, ventilation, emergency stops etc)

14 Physical risk management
Area of concern Response Trips and falls Non-slip flooring, good housekeeping Needle stick injury Dedicated sharps and glass disposal Electrical Residual current devices, Tagg testing Unanticipated risks Rapid response and risk abatement

15 Sample management Samples are extremely valuable, reagents are expensive and have strict storage requirements

16 Why are samples so valuable?
They are difficult and expensive to collect They are often irreplaceable They are easily destroyed They are labor intensive to prepare Majority of valuable samples are stored in dedicated freezers with back to base alarm systems installed

17 Managing equipment and infrastructure
Laboratory space and equipment is expensive. Equipment can also be hazardous

18 Managing equipment risks
Equipment risk is managed by adherence to specific Safe Work Procedures (SWPs) Autoclaves High pressures and temperatures Centrifuges High rotational velocities Electrophoresis gear High voltages -80oC freezer Contact freezer burns Microwaves Incorrect use

19 For your lab inspection:
We have stopped research and teaching activity for your tour of the PC2 and teaching laboratories. Even though you are just visiting, you will still need to conform with safety regulations: Closed in footwear No food or drink allowed (including chewing gum) Don’t touch anything

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