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VII edizione Capri Pediatria Capri, 28 – 30 Aprile 2014 Biomarkers nell’asma bronchiale Guglielmo Scala Napoli
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Pathogenesis of Asthma Holgate S, Clin Exp Allergy, 2008
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Pathogenesis of Asthma Holgate S, Clin Exp Allergy, 2008 La cellula Th2 è fondamentale per la maturazione dell’eosinofilo
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Pathogenesis of Asthma Holgate S, Clin Exp Allergy, 2008
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A new look at the pathogenesis of asthma Holgate ST, 2010, Clinical Science
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A new look at the pathogenesis of asthma Holgate ST, 2010, Clinical Science
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Pathogenesis of Asthma Holgate S, Clin Exp Allergy, 2008
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Pathogenesis of Asthma Holgate S, Clin Exp Allergy, 2008 Nasce il concetto di EMTU
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Lamina basale è prodotta dalle cell epiteliali Lamina reticolare (MBR) è prodotta dai fibroblasti
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A new look at the pathogenesis of asthma Holgate ST, 2010, Clinical Science
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Pathogenesis of Asthma Holgate S, Clin Exp Allergy, 2008
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Viral infections and atopy in asthma pathogenesis: new rationales for asthma prevention and treatment P. Holt & P. Sly, Nature Medicine, 2012
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Holt & Sly, Nat Med 2012
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Holt P, Curr Op Allergy Clin Immunol, 2007 ITS
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Holt & Sly, Nat Med 2012
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Smascherata la marcia atopica??
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The basics of epithelial-mesenchymal transition Kalluri R, Weinbergjj R, J Clin Invest. 2009.
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The basics of epithelial-mesenchymal transition Kalluri R, Weinbergjj R, J Clin Invest. 2009.
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A clinical pharmacological study of the potential beneficial effects of a propolis food product as an adjuvant in asthmatic patients. Khayyal MT 2003, Fundam Clin Pharmacol FVC+ 19% FEV1+30% PEFR+30% FEF 25-75+41% TNF-52% ICAM-1-65% IL-6-44% IL-8-30% IL-10+300% Asma notturno/settimana- 60 % 22 pazienti : placebo 24 pazienti : propoli
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Brazilian Green Propolis: Anti-Inflammatory Property by an Immunomodulatory Activity Machado JL et al, 2012, Evidence-Based Compl Altern Med
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Caffeic acid phenethyl ester inhibits nuclear factor-kB and protein kinase B signalling pathways and induces caspase- 3 expression in primary human CD4+ T cells Wang et al, 2009, Clin Exp Immunol The inhibitory effect of CAPE results in the inhibition of cytokine production and proliferation in primary human CD4+ T cells
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Caffeic Acid Phenethyl Ester and Its Amide Analogue Are Potent Inhibitors of Leukotriene Biosynthesis in Human Polymorphonuclear Leukocytes. Boudreau L, 2012, PlosOne
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Propolis inhibits TGF-β1-induced epithelial-mesenchymal transition in human alveolar epithelial cells via PPARγ activation. Kao HF, et al. 2013, Int Immunopharmacol TGF -
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Propolis inhibits TGF-β1-induced epithelial-mesenchymal transition in human alveolar epithelial cells via PPARγ activation. Kao HF, et al. 2013, Int Immunopharmacol TGF - Alterazioni morfologiche ↓ E - cadherin ↑ N - cadherin ↑ ROS ↑ motilità cellulare
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Propolis inhibits TGF-β1-induced epithelial-mesenchymal transition in human alveolar epithelial cells via PPARγ activation. Kao HF, et al. 2013, Int Immunopharmacol TGF - Alterazioni morfologiche ↓ E - cadherin ↑ N - cadherin ↑ ROS ↑ motilità cellulare PROPOLI
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Propolis inhibits TGF-β1-induced epithelial-mesenchymal transition in human alveolar epithelial cells via PPARγ activation. Kao HF, et al. 2013, Int Immunopharmacol TGF - Alterazioni morfologiche ↓ E - cadherin ↑ N - cadherin ↑ ROS ↑ motilità cellulare PROPOLI
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Propolis inhibits TGF-β1-induced epithelial-mesenchymal transition in human alveolar epithelial cells via PPARγ activation. Kao HF, et al. 2013, Int Immunopharmacol TGF - Alterazioni morfologiche ↓ E - cadherin ↑ N - cadherin ↑ ROS ↑ motilità cellulare PROPOLI Se pretrattiamo con CAPE (ac. Caffeico) l’effetto è di minore intensità.
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Propolis inhibits TGF-β1-induced epithelial-mesenchymal transition in human alveolar epithelial cells via PPARγ activation. Kao HF, et al. 2013, Int Immunopharmacol The results of this study suggest that natural propolis extracts may prevent TGF-β1-induced EMT in alveolar cells, which may be clinically applied in the prevention and/or treatment of EMT-related fibrotic diseases as well as airway remodeling in chronic asthma
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guglielmoscala@gmail.com
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