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VII edizione Capri Pediatria Capri, 28 – 30 Aprile 2014 Biomarkers nell’asma bronchiale Guglielmo Scala Napoli.

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Presentation on theme: "VII edizione Capri Pediatria Capri, 28 – 30 Aprile 2014 Biomarkers nell’asma bronchiale Guglielmo Scala Napoli."— Presentation transcript:

1 VII edizione Capri Pediatria Capri, 28 – 30 Aprile 2014 Biomarkers nell’asma bronchiale Guglielmo Scala Napoli

2 Pathogenesis of Asthma Holgate S, Clin Exp Allergy, 2008

3 Pathogenesis of Asthma Holgate S, Clin Exp Allergy, 2008 La cellula Th2 è fondamentale per la maturazione dell’eosinofilo

4 Pathogenesis of Asthma Holgate S, Clin Exp Allergy, 2008

5 A new look at the pathogenesis of asthma Holgate ST, 2010, Clinical Science

6 A new look at the pathogenesis of asthma Holgate ST, 2010, Clinical Science

7 Pathogenesis of Asthma Holgate S, Clin Exp Allergy, 2008

8 Pathogenesis of Asthma Holgate S, Clin Exp Allergy, 2008 Nasce il concetto di EMTU

9 Lamina basale è prodotta dalle cell epiteliali Lamina reticolare (MBR) è prodotta dai fibroblasti

10 A new look at the pathogenesis of asthma Holgate ST, 2010, Clinical Science

11 Pathogenesis of Asthma Holgate S, Clin Exp Allergy, 2008

12 Viral infections and atopy in asthma pathogenesis: new rationales for asthma prevention and treatment P. Holt & P. Sly, Nature Medicine, 2012

13 Holt & Sly, Nat Med 2012

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15 Holt P, Curr Op Allergy Clin Immunol, 2007 ITS

16 Holt & Sly, Nat Med 2012

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18 Smascherata la marcia atopica??

19 The basics of epithelial-mesenchymal transition Kalluri R, Weinbergjj R, J Clin Invest

20 The basics of epithelial-mesenchymal transition Kalluri R, Weinbergjj R, J Clin Invest

21 A clinical pharmacological study of the potential beneficial effects of a propolis food product as an adjuvant in asthmatic patients. Khayyal MT 2003, Fundam Clin Pharmacol FVC+ 19% FEV1+30% PEFR+30% FEF % TNF-52% ICAM-1-65% IL-6-44% IL-8-30% IL % Asma notturno/settimana- 60 % 22 pazienti : placebo 24 pazienti : propoli

22 Brazilian Green Propolis: Anti-Inflammatory Property by an Immunomodulatory Activity Machado JL et al, 2012, Evidence-Based Compl Altern Med

23 Caffeic acid phenethyl ester inhibits nuclear factor-kB and protein kinase B signalling pathways and induces caspase- 3 expression in primary human CD4+ T cells Wang et al, 2009, Clin Exp Immunol The inhibitory effect of CAPE results in the inhibition of cytokine production and proliferation in primary human CD4+ T cells

24 Caffeic Acid Phenethyl Ester and Its Amide Analogue Are Potent Inhibitors of Leukotriene Biosynthesis in Human Polymorphonuclear Leukocytes. Boudreau L, 2012, PlosOne

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26 Propolis inhibits TGF-β1-induced epithelial-mesenchymal transition in human alveolar epithelial cells via PPARγ activation. Kao HF, et al. 2013, Int Immunopharmacol TGF - 

27 Propolis inhibits TGF-β1-induced epithelial-mesenchymal transition in human alveolar epithelial cells via PPARγ activation. Kao HF, et al. 2013, Int Immunopharmacol TGF -  Alterazioni morfologiche ↓ E - cadherin ↑ N - cadherin ↑ ROS ↑ motilità cellulare

28 Propolis inhibits TGF-β1-induced epithelial-mesenchymal transition in human alveolar epithelial cells via PPARγ activation. Kao HF, et al. 2013, Int Immunopharmacol TGF -  Alterazioni morfologiche ↓ E - cadherin ↑ N - cadherin ↑ ROS ↑ motilità cellulare PROPOLI

29 Propolis inhibits TGF-β1-induced epithelial-mesenchymal transition in human alveolar epithelial cells via PPARγ activation. Kao HF, et al. 2013, Int Immunopharmacol TGF -  Alterazioni morfologiche ↓ E - cadherin ↑ N - cadherin ↑ ROS ↑ motilità cellulare PROPOLI

30 Propolis inhibits TGF-β1-induced epithelial-mesenchymal transition in human alveolar epithelial cells via PPARγ activation. Kao HF, et al. 2013, Int Immunopharmacol TGF -  Alterazioni morfologiche ↓ E - cadherin ↑ N - cadherin ↑ ROS ↑ motilità cellulare PROPOLI Se pretrattiamo con CAPE (ac. Caffeico) l’effetto è di minore intensità.

31 Propolis inhibits TGF-β1-induced epithelial-mesenchymal transition in human alveolar epithelial cells via PPARγ activation. Kao HF, et al. 2013, Int Immunopharmacol The results of this study suggest that natural propolis extracts may prevent TGF-β1-induced EMT in alveolar cells, which may be clinically applied in the prevention and/or treatment of EMT-related fibrotic diseases as well as airway remodeling in chronic asthma

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