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Indigenous PCV 15 - An affordable, Asia specific Pneumococcal Conjugate Vaccine – Current status of development 1 M. Kuppusamy, Ph.D Managing Director,

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Presentation on theme: "Indigenous PCV 15 - An affordable, Asia specific Pneumococcal Conjugate Vaccine – Current status of development 1 M. Kuppusamy, Ph.D Managing Director,"— Presentation transcript:

1 Indigenous PCV 15 - An affordable, Asia specific Pneumococcal Conjugate Vaccine – Current status of development 1 M. Kuppusamy, Ph.D Managing Director, Tergene Biotech Pvt. Ltd., Hyderabad

2 PCV Pneumococcal Conjugate Vaccine Design Serotypes included: 15 types of pneumococcal polysaccharides 1, 2, 3, 4, 5, 6A, 6B, 7F, 9V, 12F, 14, 18C, 19A, 19F, 23F Source of Strains: CDC, Atlanta Carrier protein: CRM 197 Diphtheria Toxin (Non-recombinant) Conjugation Chemistry: Cyanalation, Adipic acid linker, Carbo-di-imide cross linking

3 PCV - 15 PCV PCV 7PCV 10PCV 13PCV B 9V 14 18C 19F 23F F 33 6A 19A 2 12F Vaccine Formulations

4 PCV - 15 PCV RegionPCV 7PCV 10PCV 13PCV 15 North America78 %81 %88 %89 % Europe67 %76 %88 %89 % Latin America53 %72 %82 %83 % Oceania65 %72 %80 %83 % Africa40 %63 %77 %81 % Asia48 %66 %74 %78 % Region wise Serotype Coverage * Pneumococcal Regional Serotype Distribution for Pneumococcal AMC TPP, 2008

5 PCV - 15 PCV Current Status of PCV - 15 In House technology development & Proof of concept established in 2010 Production of GMP lots for pre-clinical and clinical studies under progress Commercial launch expected in 4 th quarter of 2014 Project supported by DBT, Govt. of India

6 PCV - 15 PCV THANK YOU!


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