Presentation on theme: "Long-Term Data for 884 Patients Show Vertebroplasty for Osteoporotic Spinal Fractures Provides Dramatic Pain Relief, Greatly Decreases Disability Giovanni."— Presentation transcript:
1 Long-Term Data for 884 Patients Show Vertebroplasty for Osteoporotic Spinal Fractures Provides Dramatic Pain Relief, Greatly Decreases DisabilityGiovanni Carlo ANSELMETTI, MDInstitute for Cancer Research and Treatment Candiolo (TURIN) - Italy
2 Percutaneous Vertebroplasty STUDY DESIGN We prospectively evaluated back-pain improvement, new fracture rate and complications in a large series of Osteoporotic Patients underwent to Percutaneous Vertebroplasty for vertebral fracture refractory to conservative medical treatment
3 Patients Populations 884 Patients (750 female - 134 male mean age 73,1 years) 639 Primary Osteoporosis (72,3%)245 Secondary to Steroidal therapy (27,7%)Treated on 3954 VertebraeAll procedures in Local anesthesiaPatients discharged from the Hospital the same procedural day
4 Clinical EvaluationPain was evaluated using a 11-point Visual Analogic Scale from 0 (no pain) to 10 (worst experienced pain) before and after the procedure.Disability improvement was evaluated by external Brace support and Oswestry Disability Questionnaire before and after VertebroplastyIf patients reported back-pain recurrence during follow-up clinical interview and MRI were performed to investigate new vertebral fracture
5 845/884 patients (95,6%) reported backpain improvement Visual Analog Scale Pre e Post VTP 884 patients Follow-up up to 52 monthsP<0.0001Wilcoxon signed rank TestSD±1,5SD±1,8845/884 patients (95,6%) reported backpain improvement
6 Quality of Life after PV Brace support Follow-up up to 52 months McNemar’s Test
7 Quality of Life Oswestry Disability Questionnaire 884 Pts Paired t testSD ±13,5%Considering together patients treated with PVP and Osteoplasty (a total of two hundred and twenty six), the Oswestry questionnaire showed a statistical high significant difference (unpaired t test with Welch correction was used): average of sixty-eight percent before the procedure dropped to eighteen percent after the needle and cement of the interventional radiologist.SD±6,9%
8 New Fractures in Osteoporosis 884 Patients - Follow-up up to 52 months During follow-up all patients were invited to contact us whenever backpain occurred again after PV.MR and plain radiograms showed a new vertebral fractures in:106 patients (12%)Occurred 15 days to 36 months (mean 9,4±8,7 months) after previous VertebroplastyThey were all successfully retreated!
9 Fract. on Contiguous vertebra New Fractures in Osteoporosis Fracture on Contiguous vertebra 73/106 patients (68,9%)Pts RetreatedFract. on Contiguous vertebra%Binomial exact Test1067368,9Two-tail P<0,001Highly significant
10 RETREATMENTS in Osteoporosis New Fracture during 18 months Follow-up Vertebroplasty vs. Placebo & TeriparatideOsteoporotic Pts with 1 or more vertebral collapses at baselineNew FractureDuring 18 months%Chi-squareVertebroplastyPersonal Series5477513,7PlaceboLindsay et al. Arch Intern Med 2004; 164:3536718,9P=0.04Signifcant difference!20µG Teriparatide3734211,2P=0.3No difference!40µG Teriparatide3453610,4P=0.18
11 COMPLICATIONS 18/884 patients (2%) Vertebroplasty was completed in all patients without any major complications12 (1,4%) asymptomatic pulmonary embolism6 (0,7%) nerve root irritation successfully treated by local steroidal injection
12 CONCLUSIONSVertebroplasty is safe and effective in the treatment of back-pain due to osteoporotic vertebral collapses.After Vertebroplasty patients can increase mobility and improve their quality of life.New fracture rate seems to be similar to not PV-treated osteoporotic pts reported by literature.Our data suggest that Vertebroplasty should always be proposed to patients when conservative medical treatment fails.A low complications rate can be achieved by good technique, experienced physicians and state of the art radiological equipment.Randomized studies have to be performed in the future to assess if vertebroplasty should be considered as “conventional therapy” in the treatment of not surgical vertebral fracture.Thank you for you attention.