Presentation is loading. Please wait.

Presentation is loading. Please wait.

Ideal dose Ideal dose of protein of protein substitute intake substitute intake.

Similar presentations


Presentation on theme: "Ideal dose Ideal dose of protein of protein substitute intake substitute intake."— Presentation transcript:

1 Ideal dose Ideal dose of protein of protein substitute intake substitute intake

2 What do protein substitues do What do protein substitues do?  provide 21 amino acids  help growth  lower phenylalanine levels  some provide vitamins and minerals

3 How much do we give?

4 School of Thought 1 UK advocate generous quantities of protein substitute

5 School of Thought 2 children with PKU don’t need big doses of protein substitute

6 Aim To investigate if a lower dose of protein substitute can achieve the same or better control when compared to the dosage recommended by the UK

7 Who did we study?  25 children  2-10y (median 6y)  13 girls; 12 boys  dietary treatment: x 50 mg phenylalanine exchanges x 50 mg phenylalanine exchanges - median protein equivalent intake: 2.2 g/kg/day - median protein equivalent intake: 2.2 g/kg/day

8 Dosages of protein substitute  High dose - 2 g/kg/day protein equivalent - 2 g/kg/day protein equivalent  Low dose g/kg/day protein equivalent

9 Week 1 Week 2 Week 3 Week 4 Week 5 Week 6 Week 7 7 week study

10 Week 1 Control normal dose of protein substitute

11 Week 1 Control 567 morning night day

12 Week 2 and 3 High

13 Week 2 and 3 HighLow

14 Week day Morning Night

15 Weighed food record

16 Week 4 and 5 Control normal dose of protein substitute

17 Week 5 Control 567 morning night

18 Week 6 and 7 HighLow

19 Week day Morning Night

20 Same food menu as week 3

21 Subject 1 girl 5y 5½exchanges

22 Subject 2girl 6y6 exchanges

23 Subject 3girl 7 y7 exchanges

24 Change in morning blood phenylalanine concentrations

25 Median change in blood phenylalanine concentrations a.m.p.m.

26 What are the reasons for differences in change in blood phe levels?  age: no correlation  exchanges: no correlation  PKU mutations  calorie intake

27 What are the reasons for differences in change in blood phe levels?  age: no correlation  exchanges: no correlation  PKU mutations: coming soon  calorie intake

28 Reduction in calorie intake

29 Summary  lower dosages of protein substitute increased plasma phenylalanine concentrations  in some children, it led to very poor phe control  individual differences may be due to severity of PKU  calories contributed by protein substitute is important

30 Benefits UK  evidence to justify dosage of protein substitute given  important to justify prescription costs None UK countries  should help improve dietary control


Download ppt "Ideal dose Ideal dose of protein of protein substitute intake substitute intake."

Similar presentations


Ads by Google