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1 Ω Race THE Ω RACE SYSTEM (Risk Analysis of Casual Effects)

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Presentation on theme: "1 Ω Race THE Ω RACE SYSTEM (Risk Analysis of Casual Effects)"— Presentation transcript:

1 1 Ω Race THE Ω RACE SYSTEM (Risk Analysis of Casual Effects)

2 2 Ω Race is a computing system able to combine clinical data of the patient known to the Cardiologist together with the genetic data held by the Laboratory. Ω Race is and advanced computing system to estimate the alteration of the cardiovascular risk caused by interaction of the presence of specific polymorphisms and objective clinical circumstances. What Ω Race System is? Personal profile Ω Race

3 3 Requirements to use the Ω Race System Have an Internet Connection Have an e-mail account Available printer

4 LABORATORIES CARDIOLOGISTS Ω Race Intended audience

5 Ω Race CARDIOLOGIST The cardiologist insert personal and anamnestic data of the patient into the Ω-Race System and prescribes the innovative genetic testing with Cardio Kit. The patient is sent to a Laboratory that performs Cardio Kit test. The Laboratory performs the test and inserts the genetic data into the Ω Race System. From this moment the integrated genetic risk evaluation system becomes active. The integration of the genetic and clinical profiles will generate an evaluation that will produce a scoresheet issued by the Laboratory. LABORATORY

6 CARDIOLOGIST The cardiologist gets the laboratory’s scoresheet with the calculation of the integrated genetic risk (Genetic factors integrated with traditional risk factors) at 5, 10, 15 and 20 years. The Cardiologist on the basis of the scoresheet issues a report, sets the therapy and creates its personal patient’s archive. Ω Race

7 The laboratory buys Cardio Kit Ω Race Service combination: Cardio kit and Ω Race Strip activation Key-Code The laboratory activates strips by digiting Cardio Kit Key Code in Ω Race System Cardiologist/Laboratory: Web registration with the support of Distributor. (Distributor supported by Nuclear Laser Medicine) Entering personal data of the patient Entering anamnestic data of the patient Entering polimorphisms detected on Cardio Kit strip Laboratory calculates the genetic integrated risk with Ω Race System The cardiologist releases a personalized diagnosis to the patient

8 8 The activation of a workstation, and registration to the Ω Race System, is accessible to two different figures Laboratories Register the patient (general data) Entering anamnestic data Generate an account Makes the follow-up Information exchange PIN share Register the patient Entering genetic data If authorized can enter the personal and anamnestic data Generate a report Ω Race Doctors: cardioligists

9 9 Ω Race PIN Doctor (ex: Cardiologist) Laboratory Ω RACE @ Nestor 2012-2014 – Customized risk factor Fri, 26 Sep 2014 14:31:24 Laboratory of Analysis: LAB A Patients Data: Surname: Van Beethoven Name: Ludwig Address: Bonnstrasse 1, Bonn Personal Code: VBELDWXX1770XX Authorization PIN: 8C6325 Ω RACE @ Nestor 2012-2014 – Customized risk factor Fri, 26 Sep 2014 14:31:24 Laboratory of Analysis: LAB A Patients Data: Surname: Van Beethoven Name: Ludwig Address: Bonnstrasse 1, Bonn Personal Code: VBELDWXX1770XX Authorization PIN: 8C6325 PIN code univocally identifies the patient

10 Ω Race CARDIOLOGIST LABORATORIES * The Insertion of the Patient’s e-mail address is necessary to send the report Personal Data of Patient Anamnestic Data of Patient Weight and height Hypertension Arterial pressure Hypercholesterolemia Total Cholesterol LDL - HDL Drugs Smoke Diabetes Cardiovascular Name and Surname Sex Age Address Name of the Cardiologist Cardiologist’s e-mail address *Patient’s e-mail address

11 11 LABORATORIES Ω Race Inclusion of genetic polimorphysms and scoresheet generation SCORESHEET Example of how introduce data: Locus : 9p21 SNP : RS 1333049 Possible combination to select: ● GG ● GC ● CC Personal and anamnestic data of the patient, recorded into the patient’s chart, can be displayed by Laboratory through the PIN code If they have previously been entered into the system by the Cardiologist

12 How to interpretate the integrated genetic risk? ❖ The risk factor is presented as a colored cells matrix. Colors indicate the risk level (Green: low risk, …, violet: high risk) of getting a Cardio Vascular Disease (CVD). ❖ The first column shows the integrated genetic risk to next 5 years. Further columns show the risk at ranges of 5 years each in the future up to a forecast of 20 years. ❖ As example “X” sign in column “Risk at 15 years” into a dark green cell means the probability of a Cardio Vascular Disease event in next 15 years goes with a probability between 5 and 10% (as indicated left side under “Key” column). Namely took 100 persons with same characteristics of the patient under examination, in between of 5 and 10 of them will get a CVD in next 15 years. ❖ Finally it is possible to compare the integrated genetic risk with the same risk calculated without the genetic profile. Less than 5% Risk at 5 years 5% - 10% 15% - 20% 20% - 30% Over 30% Risk at 10 years Risk at 15 years Risk at 20 years 10% - 15% CVD Risk VI CVD Risk V CVD Risk IV CVD Risk III CVD Risk II CVD Risk I Key Integrated Genetic Risk Compare to clinical risk

13 13 LABORATORY Ω Race CARDIOLOGIST Scoresheet transmission to Cardiologist and Patient

14 14 Ω Race Cardiologist evaluates the risk factor indicated in the scoresheet and generates a report CARDIOLOGIST REPORT

15 How to interpretate the integrated genetic risk? ❖ This case shows two matrices. Left one considers into evaluation genetic factors while the right one is an evaluation of the risk without taking into account genetic factors. ❖ Notice how for the patient under evaluation, despite having a very low risk factor, the risk of a Cardio Vascular Disease (CAD) increases from “Less than 5%” to “5% - 10%” at 15 years, if genetic factors are taken into consideration in addiction to traditional clinical risks. Risk at 5 years Risk at 10 years Risk at 15 years Risk at 20 years Less than 5% 5% - 10% 15% - 20% 20% - 30% Over 30% 10% - 15% CVD Risk VI CVD Risk V CVD Risk IV CVD Risk III CVD Risk II CVD Risk I Risk at 5 years Risk at 10 years Risk at 15 years Risk at 20 years Risk at 5 years Risk at 10 years Risk at 15 years Risk at 20 years Key Integrated Genetic Risk Traditional Clinical Risk

16 16 Ω Race PRIVACY The system is protected by: 1. User Name 3. PIN 2. Password 4. Security protocol HyperText Transfer Protocol over Secure Socket Layer (HTTPS) 5. The Ω Race System do not divulge sensitive information about patients like personal data

17 17 Ω Race Information for Cardio Kit may be found: - at www.nlm.itwww.nlm.it - by writing an e-mail at export@nlm.itexport@nlm.it - soon at www.cardiokit-nlm.com dedicated website to Cardio Kit currently under construction for english version.www.cardiokit-nlm.com SUPPORT TO THE SERVICE SYSTEM CARDIO KIT AND Ω RACE Where & how?

18 18 Ω Race Thanks For Your Attention !


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